About the Mirkin Lab
The field of research in our laboratory, broadly defined, is DNA structure and functioning.
We are primarily interested in the role of various DNA repeats in the maintenance of the genome and their effects on major genetic transactions in norm and disease. We also study complex interplay between genetic machineries, operating simultaneously at a given genomic segment, such as replication and transcription. Finally, we are fascinated by DNA conformations that differ from the canonical B-DNA. Thus, a significant part of our research is devoted to unusual DNA structures and their biological roles.