Publications - Cloned
All Peer-reviewed Publications
2022
Ion Channel Drugs Suppress Cancer Phenotype in NG108-15 and U87 Cells: Toward Novel Electroceuticals for Glioblastoma
Mathews, J., Kuchling, F., Baez-Nieto, D., Diberardinis, M., Pan, J. Q., and Levin, M., (2022)
Cancers 14(6): 1499
Modular cognition
Levin, M., and Yuste, R., (2022)
Aeon Essays [cover]
Design for an Individual: Connectionist approaches to the evolutionary transitions in individuality
Watson, R. A., Levin, M., and Buckley, C. L., (2022)
Frontiers in Ecology and Evolution, in press
Technological Approach to Mind Everywhere (TAME): an experimentally-grounded framework for understanding diverse bodies and minds
Levin, M., (2022)
Frontiers in Systems Neuroscience, in press
Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adult Xenopus laevis
Murugan, N. J., Vigran, H. J., Miller, K., Golding, A., Pham, Q. L., Sperry, M., Rasmussen-Ivey, C., Kane, A. W., Kaplan, D. L., and Levin, M., (2022)
Science Advances, 8(4): abj2164 [cover]
When left does not seem right: epigenetic and bioelectric differences between left- and right-sided breast cancer
Masuelli, S., Sebastian, R., Campoy, E., Branham, M. T., Marzese, D. M., Matthew, S., DeBlas, G., Rodolfo, A., Levin, M., and Roque, M., (2022)
Molecular Medicine, 28:15
Minimal developmental computation: a causal network approach to understand morphogenetic pattern formation
Manicka, S., and Levin, M., (2022)
Entropy, 24: 107
A Computational Approach to Explaining Bioelectrically-induced Persistent, Stochastic Changes of Axial Polarity in Planarian Regeneration
Grodstein, J., and Levin, M., (2022)
Bioelectricity, in press
2021
Multi-scale Chimerism: an experimental window on the algorithms of anatomical control
Nanos, V., (2021)
Cells and Development, 169: 203764
Evolution and emergence: higher order information structure in protein interactomes across the tree of life
Klein, B., Hoel, E., Swain, A., Griebenow, R., and Levin, M., (2022)
Integrative Biology, 1-12 [cover]
New Clues about the Origins of Biological Intelligence
Yuste, R., and Levin, M., (2021)
Scientific American, December 2021
Potassium channel-driven bioelectric signalling regulates metastasis in triple-negative breast cancer
Payne, S. L., Ram, P., Srinivasan, D. H., Le, T. T., Levin, M., and Oudin, M. J., (2021)
EBioMedicine, 75:103767
Kinematic self-replication in reconfigurable organisms
Kriegman, S., Blackiston, D., Levin, M., and Bongard, J., (2021)
Proceedings of the National Academy of Science, 118(49): e2112672118
Behaviorist Approaches to Investigating Memory and Learning: A Primer for Synthetic Biology and Bioengineering
Abramson, C., and Levin, M., (2021)
Communicative & Integrative Biology, 14(1): 230-247
A Comprehensive Conceptual and Computational Dynamics Framework for Autonomous Regeneration Systems
Minh-Thai, T. N., Samarasinghe, S., and Levin, M., (2021)
Artificial Life, 27: 80-104
Cell Systems Bioelectricity: How Different Intercellular Gap Junctions Could Regionalize a Multicellular Aggregate
Riol, A., Cervera, J., Levin, M., and Mafe, S., (2021)
Cancers, 13(21) 5300
Stability and robustness properties of bioelectric networks: A computational approach
Grodstein, J., and Levin, M., (2021)
Biophysics Review, 2: 031305
Unmixing octopus camouflage by multispectral mapping of Octopus bimaculoides' chromatic elements
Guidetti, G., Levy, G., Matzeu, G., Finkelstein, J. M., Levin, M., and Omenetto, F. G., (2021)
Nanophotonics, 10(9): 2441-2450
Beyond Neurons: Long Distance Communication in Development and Cancer
McMillen, P., Oudin, M. J, Levin, M., and Payne, S. L., (2021)
Frontiers in Cell and Developmental Biology, 9: 2637
Bioelectrical approaches to cancer as a problem of the scaling of the cellular self
Levin, M., (2021)
Progress in Biophysics and Molecular Biology, 165: 102-113
Scale invariant robot behavior with fractals
Kriegman, S., Nasab, A-M., Blackiston, D., Steele, H., Levin, M., Kramer-Bottiglio, R., and Bongard, R., (2021)
Robotics: Science and Systems (RSS), 10.15607/RSS.2021.XVII.059
Morphology changes induced by intercellular gap junction blocking: a reaction-diffusion mechanism
Cervera, J., Levin, M., and Mafe, S., (2021)
BioSystems, 209:104511
Metabolic limits on classical information processing by biological cells
Fields, C., and Levin, M., (2021)
BioSystems, 209: 104513
Inducing Vertebrate Limb Regeneration: A Review of Past Advances and Future Outlook
Davidian, D., and Levin, M. (2021)
Cold Spring Harbor Perspectives in Biology, doi: 10.1101/cshperspect.a040782
Minimal physicalism as a scale-free substrate for cognition and consciousness
Fields, C., Glazebrook, J. F., and Levin, M., (2021)
Neuroscience of Consciousness, 2021(2): niab013
Mechanosensation Mediates Long-Range Spatial Decision-Making in an Aneural Organism
Murugan, N., Kaltman, D., Jin, H., Chien, M., Flores, R., Nguyen, C., Tuzoff, D., Minabutdinov, A., Kane, A., Novak, R., Ingber, D., and Levin, M. (2021)
Advanced Materials, 2008161 [cover]
Self-organising Textures
Niklasson, E., Mordvintsev, A., Randazzo, E., and Levin, M., (2021)
Distill, doi: 10.23915/distill.00027.003
Life, death, and self: Fundamental questions of primitive cognition viewed through the lens of body plasticity and synthetic organisms
Levin, M., (2021)
Biochemical and Biophysical Research Communications, 564: 114-133 [cover]
Adversarial Reprogramming of Neural Cellular Automata: a robustness investigation
Randazzo, E., Mordvintsev, A., Niklasson, E., and Levin, M., (2021)
Distill, DOI: 10.23915/distill.00027.004
Multispectral mapping of octopus' skin
Guidetti, G., Levy, G., Matzeua, G., Finkelstein, J., Levin, M., Omenetto, F., (2021)
Nanophotonics, in press
Synthetic living machines: A new window on life
Ebrahimkhani, M., and Levin, M., (2021)
iScience, 24(5): 102505
A cellular platform for the development of synthetic living machines
Blackiston, D., Lederer, E., Kriegman, S., Garnier, S., Bongard, J., and Levin, M., (2021)
Science Robotics, 6: eabf1571
Unlimited plasticity of embodied, cognitive subjects: a new playground for the UAL framework
Levin, M., (2021)
Biology and Philosophy, 36: #17
Learning and synaptic plasticity in 3D bioengineered neural tissues
Cairns, D. M., Rusk, W., Levin, M., Rouleau, N., and Kaplan, D., (2021)
Neuroscience Letters, 750: 135799
Studying Protista WBR and repair using Physarum polycephalum
Sperry, M. M., Murugan, N. J., Levin, M., (2021)
Methods in Molecular Biology, in press
Bioelectric Signaling: Reprogrammable Circuits Underlying Embryogenesis, Regeneration, and Cancer
Levin, M., (2021)
Cell, 184(8): 1971-1989
Uncovering cognitive similarities and differences, conservation and innovation
Levin, M., Keijzer, F., Lyon, P., and Arend, D., (2021)
Philosophical Transactions of the Royal Society B, 375 (1820): 20200458 [cover]
Living things are not (20th Century) machines: updating mechanism metaphors in light of the modern science of machine behavior
Bongard, J., and Levin, M., (2021)
Frontiers in Ecology and Evolution, 9, 10.3389/fevo.2021.650726
Reframing cognition: getting down to biological basics
Lyon, P., Keijzer, F., Arendt, D., and Levin, M., (2021)
Philosophical Transactions of the Royal Society B, 376 (1821): 20190750 [cover]
Bistability of Somatic Pattern Memories: Stochastic Outcomes in Bioelectric Circuits Underlying Regeneration
Pezzulo, G., Lapalme, J., Durant, F., and Levin, M., (2021)
Philosophical Proceedings of the Royal Society B, 375: 20190765
Gene Regulatory Networks Exhibit Several Kinds of Memory: Quantification of Memory in Biological and Random Transcriptional Networks
Biswas, S., Manicka, S., Hoel, E., and Levin, M., (2021)
iScience, 24(3): 102131
Rewiring Endogenous Bioelectric Circuits in the Xenopus laevis Embryo Model
Nanos, V., and Levin, M., (2021)
Methods in Molecular Biology, 2258:93-103
Epigenetic control of myeloid cells behavior by Histone Deacetylase Activity (HDAC) during tissue and organ regeneration in Xenopus laevis
Pentagna, N., Pinheiro da Costa, T., Soares Dos Santos, F., Martins de Almeida F., Martinez, A. M. B., Abreu, J. G., Levin, M., and Carneiro, K., (2021)
Developmental and Comparative Immunology, 114:103840
2020
Self-classifying MNIST Digits
Randazzo, E., Mordvintsev, A., Niklasson, E., Levin, M., and Greydanus, S., (2020)
Distill, doi: 10.23915/distill.00027.002
Growing Neural Cellular Automata
Mordvintsev, A., Randazzo, E., Niklasson, E., and Levin, M., (2020)
Distill, doi: 10.23915/distill.00027.002
Community effects allow bioelectrical reprogramming of cell membrane potentials in multicellular aggregates: Model simulations
Cervera, J., Ramirez, P., Levin, M., and Mafe, S., (2020)
Physical Review E, 102: 052412
How Do Living Systems Create Meaning?
Fields, C., and Levin, M., (2020)
Philosophies, 5(4): 36
Machine Learning-Driven Bioelectronics for Closed-Loop Control of Cells
Selberg, J., Jafari, M., Mathews, J., Jia, M., Pansodtee, P., Dechiraju, H., Wu, C., Cordero, S., Flora, A., Yonas, N., Jannetty, S., Diberardinis, M., Teodorescu, M., Levin, M., Gomez, M., and Rolandi, M., (2020)
Advanced Intelligent Systems, 2000140 [cover]
Precise control of ion channel and gap junction expression is required for patterning of the regenerating axolotl limb
Sousounis, K., Erdogan, B., Levin, M., and Whited, J., (2020)
International Journal of Developmental Biology, 64: 485-494
Why isn't sex optional? Stem-cell competition, loss of regenerative capacity, and cancer in metazoan evolution
Fields, C., and Levin, M., (2020)
Communicative & Integrative Biology, 13(1): 170-183
How to understand cells, tissues and organisms as agents with agendas
Levin, M., and Dennett, Daniel C., (2020)
Aeon Essays
Shape changing robots: bioinspiration, simulation, and physical realization
Shah, D., Yang, B., Kriegman, S., Levin, M., Bongard, J., and Kramer-Bottiglio, R., (2020)
Advanced Materials, in press
How Groups of Cells Cooperate to Build Organs and Organisms
Levin, M., (2020)
The Scientist [cover]
Does evolution have a target morphology?
Fields, C., and Levin, M., (2020)
Organisms, 4(1): 57-76
Bioelectronic Control of Chloride Ions and Concentration with Ag/AgCl Contacts
Jia, M., Dechiruji, H., Selberg J., Pansodtee P., Mathews, J., Wu, C., Levin, M., Teodorescu, M., and Rolandi, M., (2020)
APL Materials, 8(9): 091106
Nervous System and Tissue Polarity Dynamically Adapt to New Morphologies in Planaria
Bischof, J., Day, M., Miller, K., LaPalme, J., and Levin, M., (2020)
Developmental Biology, 467 (1-2): 51-65 [cover]
Integrating Variational Approaches to Pattern Formation into a Deeper Physics: Reply to comments on "Morphogenesis as Bayesian Inference: A Variational Approach to Pattern Formation and Manipulation in Complex Biological Systems"
Kuchling, F., Friston, K., Georgiev, G., and Levin, M., (2020)
Physics of Life Reviews, 33:125-128
On the coupling of mechanics with bioelectricity and its role in morphogenesis
Leronni, A., Bardella, L., Dorfmann, L., Pietak, A., and Levin, M., (2020)
Journal of the Royal Society Interface, 17: 20200177
Emergence of Informative Higher Scales in Biological Systems: a computational toolkit for optimal prediction and control
Hoel, E., and Levin, M., (2020)
Communicative & Integrative Biology, 13(1): 108-118
A 3D tissue model of traumatic brain injury with excitotoxicity that is inhibited by chronic exposure to gabapentinoids
Rouleau, N., Bonzanni, M., Erndt-Marino, J., Sievert, K., Ramirez, C., Rusk, W., Levin, M., and Kaplan, D., (2020)
Biomolecules, 10: 1196
Applications and ethics of computer-designed organisms
Levin, M., Bongard, J., and Lunshof, J.E, (2020)
Nature Reviews Molecular Cell Biology, 21: 655–656
Opinion: Use the Pandemic to Expand the Lab to the Home
Levin, M., (2020)
The Scientist
Regulation of axial and head patterning during planarian regeneration by a commensal bacterium
Williams, K., Bischof, J., Lee, F., Miller, K., LaPalme, J., Wolfe, B., and Levin, M., (2020)
Mechanisms of Development, 163:103614 [cover]
Competitive and Coordinative Interactions between Body Parts Produce Adaptive Developmental Outcomes
Gawne, R., McKenna, K., and Levin, M., (2020)
BioEssays, 42: 1900245 [cover]
Scale-Free Biology: Integrating Evolutionary and Developmental Thinking
Fields, C., and Levin, M., (2020)
BioEssays, 42: 1900228
HCN2 Channel-induced Rescue of Brain Teratogenesis via local and long-range bioelectric repair
Pai, V., Cervera, J., Mafe, S., Willocq, V., Lederer, E., and Levin, M., (2020)
Frontiers in Cellular Neuroscience, 14: 136
Bioelectrical Coupling of Single-Cell States in Multicellular Systems
Cervera, J., Levin, M., Mafe, S., (2020),
J. Phys. Chem. Lett. 11, XXX, 3234-3241, doi.org/10.1021/acs.jpclett.0c00641
von Willebrand factor D and EGF domains is an evolutionarily conserved and required feature of blastemas capable of multitissue appendage regeneration
Leigh, N. D., Sessa, S., Dragalzew, A. C., Payzin‐Dogru, D., Sousa, J. F., Aggouras, A. N., Johnson, K., Dunlap, G. S., Haas, B. J., Levin, M., Schneider, I., Whited, J. L., (2020)
Evolution & Development, 22: 297-311 [cover]
Sertraline induces DNA damage and cellular toxicity in Drosophila that can be ameliorated by antioxidants
Jajoo, A., Donlon, C., Shnayder, S., Levin, M., and McVey, M., (2020)
Scientific Reports, 10: 4512
Revisiting Burr and Northrop's 'The Electro-Dynamic Theory of Life'
Levin, M., (2020)
Biological Theory, 15:83–90
Eya2 promotes cell cycle progression by regulating DNA damage response during vertebrate limb regeneration
Sousounis, K., Bryant, D. M., Fernandez, J. M., Eddy, S. S., Tsai, S. L., Gundberg, G. C., Han, J., Courtemanche, K., Levin, M., and Whited, J. L., (2020)
eLIFE, 9:e51217
Scalable sim-to-real transfer of soft robot designs
Kriegman, S., Nasab, A. M., Shah, D., Steele, H., Branin, G., Levin, M., Bongard, J. and Kramer-Bottiglio, R. (2020)
Proceedings of the 3rd IEEE International Conference on Soft Robotics (RoboSoft 2020), p. 359-366
Does regeneration recapitulate phylogeny?
Fields, C., and Levin, M., (2020)
Communicative and Integrative Biology, 13(1): 27-38
An in vivo brain–bacteria interface: the developing brain as a key regulator of innate immunity
Herrera-Rincon, C., Pare, J-F., Martyniuk, C. J., Jannetty, S. K., Harrison C., Fischer, A., Dinis, A., Keshari, V., Novak, R., and Levin, M., (2020)
NPJ Regenerative Medicine, 5:2
A Meta-Analysis of Bioelectric Data in Cancer, Embryogenesis, and Regeneration
Srivastava, P., Kane, A., Harrison, C., and Levin, M., (2020)
Bioelectricity, 3(1): 42-67
Toward Decoding Bioelectric Events in Xenopus Embryogenesis: New Methodology for Tracking Interplay between Calcium and Resting Potentials In Vivo
McMillen, P., Novak, R., and Levin, M., (2020)
Journal of Molecular Biology, 432: 605-620 [cover]
Formin, an opinion
Davison, A., McDowell, G. S., Holden, J. M., Johnson, H. F., Wade, C. M., Chiba, S., Jackson, D. J., Levin, M., and Blaxter, M. L., (2020),
Development, 147: dev187427
Optogenetically induced cellular habituation in non-neuronal cells
Bonzanni, M., Rouleau, N., Levin, M., and Kaplan, D. L., (2020)
PLOS One, 15(1):e0227230
Extra-genomic instructive influences in morphogenesis: A review of external signals that regulate growth and form
Tung, A., and Levin, M., (2020)
Developmental Biology, 461: 1-12 [cover]
A Scalable Pipeline for Designing Reconfigurable Organisms
Kriegman, S., Blackiston, D., Levin, M., and Bongard, J., (2020)
Proceedings of the National Academy of Sciences of the United States, doi/10.1073/pnas.1910837117
Assessment of Enrichment of Human Mesenchymal Stem Cells Based on Plasma and Mitochondrial Membrane Potentials
Kamaldinov, T., Erndt-Marino, J., Levin, M., Kaplan, D. L., and Hahn, M. S., (2020)
Bioelectricity, 2(1): 21-32
Post-SSRI Sexual Dysfunction: a bioelectric mechanism?
Healy, D., Faber, C., Lapalme, J., and Levin, M., (2020)
Bioelectricity, 2(1): 7-13
The Biophysics of Regenerative Repair Suggests New Perspectives on Biological Causation
Levin, M., (2020)
BioEssays, 42: 1900146
Bioelectrical model of head-tail patterning based on cell ion channels and intercellular gap junctions
Cervera, J., Meseguer, S., Levin, M., and Mafe, S., (2020)
Bioelectrochemistry, 132: 107410
Morphological Coordination: A Common Ancestral Function Unifying Neural and Non-Neural Signaling
Fields, C., Bischof, J., and Levin, M., (2020)
Physiology, 35: 16-30
2019
Defined extracellular ionic solutions to study and manipulate the cellular resting membrane potential
Bonzanni, M., Payne, S. L., Adelfio, M., Kaplan, D. L., Levin, M., and Oudin, M. J., (2019)
Biology Open, 9(1): bio048553
Endogenous Bioelectrics in Development, Cancer, and Regeneration: Drugs and Bioelectronic Devices as Electroceuticals for Regenerative Medicine
Levin, M., Selberg, J., and Rolandi, M., (2019)
iScience, 22: 519–533
Modeling somatic computation with non-neural bioelectric networks
Manicka, S., and Levin, M., (2019)
Scientific Reports 9: 18612, doi:10.1038/s41598-019-54859-8
Interdisciplinary Approach Needed to Crack Morphogenesis
Finkelstein J., McLaughlin K., Levin M. (2019)
The Scientist, December 2019
The Computational Boundary of a 'Self': Developmental Bioelectricity Drives Multicellularity and Scale-Free Cognition
Levin, M., (2019)
Frontiers in Psychology, 10:2688, doi: 10.3389/fpsyg.2019.02688
Regenerative Adaptation to Electrochemical Perturbation in Planaria: A Molecular Analysis of Physiological Plasticity
Emmons-Bell, M., Durant, F., Tung, A., Pietak, A., Miller, K., Kane, A., Martyniuk, C. J., Davidian, D., Morokuma, J., and Levin, M., (2019)
iScience, 22: 147-165
L-type voltage-gated Ca2+ channel CaV1.2 regulates chondrogenesis during limb development
Atsuta, Y., Tomizwa, R. R., Levin, M., and Tabin, C. J., (2019)
Proceedings of the National Academy of Sciences of the United States, 116(43): 21592-21601
Hyperosmolar potassium inhibits myofibroblast conversion and reduces scar tissue formation
Grasman, J., Williams, M., Razis, C., Bonzanni, M., Golding, A., Cairns, D. M., Levin, M., and Kaplan, D. L., (2019)
ACS Biomater. Sci. Eng., 5(10): 5327-5336
Managing Ideas, People, and Projects: Organizational Tools and Strategies for Researchers
Levin, S., and Levin, M., (2019)
iScience, 20: 278–291
Bioelectric control of metastasis in solid tumors
Payne, S. L., Levin, M., and Oudin, M. J., (2019)
Bioelectricity, 1(3): 114-130
Somatic Multicellularity as a Satisficing Solution to the Prediction-Error Minimization Problem
Fields, C., and Levin, M., (2019)
Communicative & Integrative Biology, 12(1): 119-132
A flow through device for simultaneous dielectrophoretic cell trapping and AC electroporation
Punjiya, M., Nehad, H. R., Mathews, J., Levin, M., Sonkusale, S., (2019)
Scientific Reports, 9:11988
Bioelectrical controls of morphogenesis: from ancient mechanisms of cell coordination to biomedical opportunities
Whited, J., and Levin, M., (2019)
Current Opinion in Genetics & Development, 57: 61-69 [cover]
Reverse-engineering growth and form in Heidelberg
Levin, M., and Martinez-Arias, A., (2019)
Development, 146: dev177261
Automated Shapeshifting for Function Recovery in Damaged Robots
Kriegman, S., Walker, S., Shah, D. S., Kramer-Bottiglio, R., and Bongard, J., (2019)
Proceedings of Robotics: Science and Systems XV: 28
From non-excitable single-cell to multicellular bioelectrical states supported by ion channels and gap junction proteins: electrical potentials as distributed controllers
Cervera, C., Pai, V. P., Levin, M., and Mafe, S., (2019)
Progress in Biophysics and Molecular Biology, 149: 39-53 [cover]
On the generalization of habituation: how discrete biological systems respond to repetitive stimuli
Bonzanni, M., Rouleau, N., Levin, M., and Kaplan, D., (2019)
BioEssays, 41(7): 1900028
Morphogenesis as Bayesian Inference: a Variational Approach to Pattern Formation and Control in Complex Biological Systems
Kuchling, F., Friston, K., Georgiev, G., and Levin, M., (2019)
Physics of Life Reviews, 33: 88-108
Live Imaging of Intracellular pH in Planarians Using the Ratiometric Fluorescent Dye SNARF-5F-AM
Beane, W. S., Adams, D. S., Morokuma, J., and Levin, M., (2019)
Biology Methods and Protocols, 4(1): bpz005
Synchronization of Bioelectric Oscillations in Networks of Nonexcitable Cells: From Single-Cell to Multicellular States
Cervera, J., Manzanares, J. A., Mafe, S., and Levin, M., (2019)
Journal of Physical Chemistry B, 123: 3924-3934 [cover]
The Cognitive Lens: a primer on conceptual tools for analysing information processing in developmental and regenerative morphogenesis
Manicka, S., and Levin, M., (2019)
Philosophical Transactions of the Royal Society B, 374: 20180369
Neural control of body-plan axis in regenerating planaria
Pietak, A., Bischof, J., LaPalme, J., Morokuma, J., and Levin, M., (2019)
PLOS Computational Biology, 15(4): e1006904
A Call for a Better Understanding of Causation in Cell Biology
Bizzari, M., Brash, D., Briscoe, J., Grieneisen, V., Stern, C. D., and Levin, M., (2019)
Nature Reviews Molecular Cell Biology, 20(5): 261-262
Membrane potential depolarization alters calcium flux and phosphate signaling during osteogenic differentiation of human mesenchymal stem cells
Sundelacruz, S., Moody, A. T., Levin, M., and Kaplan, D., (2019)
Bioelectricity, 1(1): 56-66
Toward modeling regeneration via adaptable echo state networks
Hammelman, J., Siegelmann, H., Manicka, S., and Levin, M., (2019)
in A. Adamatzky, S. Akl, and G. Sirakoulis (Eds.), From parallel to emergent computing, Chapter 6, pages 117-133, CRC Press: Boca Raton, FL
Selective Serotonin Reuptake Inhibitor Use During Pregnancy and Major Malformations: The Importance of Serotonin for Embryonic Development and the Effect of Serotonin Inhibition on the Occurrence of Malformations
Berard, A., Levin, M., Sadler, T., and Healy, D., (2019)
Bioelectricity, 1(1): 18-29
Effects of ivermectin exposure on regeneration of D. dorotocephala planaria: exploiting human-approved ion channel drugs as morphoceuticals
Ferenc, N. N., and Levin, M., (2019)
Macromolecular Bioscience, 19(3): 1800237 [cover]
Planarian Regeneration as a Model of Anatomical Homeostasis: Recent Progress in Biophysical and Computational Approaches
Levin, M., Pietak, A., and Bischof, J., (2019),
Seminars in Cell and Developmental Biology, 87: 125-144
The role of early bioelectric signals in the regeneration of planarian anterior/posterior polarity
Durant, F., Bischof, J., Fields, C., Morokuma, J., LaPalme, J., Hoi, A., and Levin, M., (2019)
Biophysical Journal, 116(5): 948-961
EDEn – Electroceutical Design Environment: Ion Channel Tissue Expression Database with Small Molecule Modulators
Churchill, C. D. M., Winter, P., Tuszynski, J. A., and Levin, M., (2019)
iScience, 11:42-56
2018
Multiscale Memory and Bioelectric Error Correction in the Cytoplasm-Cytoskeleton-Membrane System
Fields, C., and Levin, M., (2018)
Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 10(2): e1410 [cover]
A Computational Framework for Autonomous Self-repair Systems
Minh-Thai, T. N., Aryal, J., Samarasinghe, S., and Levin, M., (2018)
in Mitrovic, T., Xue, B., and Li, X. (Eds.), AI 2018: Advances in Artificial Intelligence, p153-159. Lecture Notes in Computer Science, vol 11320. Springer, Cham
Ahead of the Curve: hidden breakthroughs in the biosciences
Adams, D. S., and Levin, M., (2018)
Vol. 2, IOP Publishing Ltd: Bristol [cover]
The bacterial metabolite indole inhibits regeneration of the planarian flatwork Dugesia japonica
Lee, F. J., Williams, K. B., Levin, M., and Wolfe, B. E., (2018)
iScience, 10: 135-148
Brief Local Application of Progesterone via a Wearable Bioreactor Induces Long-Term Regenerative Response in Adult Xenopus Hindlimb
Herrera-Rincon, C., Golding, A. S., Moran, K. M., Harrison, C., Martyniuk, C. J., Guay, J. A., Zaltsman, J., Carabello, H., Kaplan, D. L., and Levin, M., (2018)
Cell Reports, 25(6): 1593-1609
Perspective: the promise of multi-cellular engineered living systems
Kamm, R. D., Bashir, R., Arora, N., Dar, R. D., Gilette, M. U., Griffith, L. G., Kemp, M. L., Kinlaw, K., Levin, M., Martin, A. C., McDevitt, T. C., Nerem, R. M., Powers, M. J., Saif, T. A., Sharpe, J., Takayama, S., Takeuchi, S., Weiss, R., Ye, K., Yevick, H. G., and Zaman, M. H., (2018)
APL Bioengineering, 2(4): 040901
Ivermectin promotes peripheral nerve regeneration during wound healing
Cairns, D. M., Giordano, J. E., Conte, S., Levin, M., and Kaplan, D. L., (2018)
ACS Omega, 3(10): 12392-12402
Activating PAX gene family paralogs to complement PAX5 leukemia driver mutations
Hart, M. R., Anderson, D. J., Porter, C. C., Neff, T., Levin, M., Horwitz, M. S., (2018)
PLoS Genetics, 14(9): 1007642
Cross-limb Communication During Xenopus Hind-limb Regenerative Response: Non-Local Bioelectric Injury Signals
Busse, S. M., McMillen, P. T., and Levin, M., (2018)
Development, 145(19). pii: dev164210
Pattern Regeneration in Coupled Networks
Moore, D. G., Walker, S. I., and Levin, M., (2018)
in T. Ikegami, N. Virgo, O. Witkowski, M. Oka, R. Suzuki and H. Iizuka (Eds.), ALIFE 2018: The 2018 Conference on Artificial Life. MIT Press: Tokyo, p. 204-205.
Modeling Cell Migration in a Simulated Bioelectrical Signaling Network for Anatomical Regeneration
Ferreira, G. B. S., Scheutz, M., and Levin, M., (2018)
in T. Ikegami, N. Virgo, O. Witkowski, M. Oka, R. Suzuki and H. Iizuka (Eds.), ALIFE 2018: The 2018 Conference on Artificial Life. MIT Press: Tokyo, p. 194-201.
From Physics to Pattern: Uncovering Pattern Formation in Tissue Electrophysiology
Brodsky, M., and Levin, M., (2018)
in T. Ikegami, N. Virgo, O. Witkowski, M. Oka, R. Suzuki and H. Iizuka (Eds.), ALIFE 2018: The 2018 Conference on Artificial Life. MIT Press: Tokyo, p. 351-358.
Inform: Efficient Information-Theoretic Analysis of Collective Behaviors
Moore, D. G., Valentini, G., Walker, S. I., and Levin, M., (2018)
Frontiers in Robotics and AI, 5: 60
Embodying Markov blankets. Comment on 'Answering Schrödinger's question: A free-energy formulation' by Maxwell James Désormeau Ramstead et al
Pezzulo, G., and Levin, M., (2018)
Physics of Life Reviews, 24: 32-36
Bioelectrical coupling in multicellular domains regulated by gap junctions: a conceptual approach
Cervera, J., Pietak, A., Levin, M., and Mafe, S., (2018)
Bioelectrochemistry, 123: 45-61 [cover]
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Bioelectrical control of positional information in development and regeneration: a review of conceptual and computational advances
Pietak, A., and Levin, M., (2018)
Progress in Biophysics and Molecular Biology, 137: 52-68
The Body Electric 2.0: Recent Advances in Developmental Bioelectricity for Regenerative and Synthetic Bioengineering
Mathews, J., and Levin, M., (2018)
Current Opinion in Biotechnology, 52: 134-144
Avian models and the study of invariant asymmetry: how the chicken and the egg taught us to tell right from left
Monsoro-Burq, A. H., and Levin, M., (2018)
International Journal of Developmental Biology, 62(1-3): 63-77
Are planaria individuals? What regenerative biology is telling us about the nature of multicellularity
Fields, C., and Levin, M., (2018)
Evolutionary Biology, 45(3): 237–247
HCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns
Pai, V. P., Pietak, A., Willocq, V., Ye, B., Shi, N-Q., and Levin, M., (2018)
Nature Communications, 9(1): 998
Inverse Drug Screening of Bioelectric Signaling and Neurotransmitter Roles: Illustrated Using a Xenopus Tail Regeneration Assay
Sullivan, K. G., and Levin, M., (2018)
Cold Spring Harbor Protocols, 2018(3): pdb.prot099937
The bioelectric code: An ancient computational medium for dynamic control of growth and form
Levin, M., and Martyniuk, C. J., (2018)
BioSystems, 164: 76-93
Niclosamide rescues microcephaly in a humanized in vivo model of Zika infection using human induced neural stem cells
Cairns, D. M., Boorgu, D. S. S. K., Levin, M., and Kaplan, D. L., (2018)
Biology Open, 7(1): bio031807
Booting up the organism during development: pre-behavioral functions of the vertebrate brain in guiding body morphogenesis
Herrera-Rincon, C., and Levin, M., (2018)
Communicative & Integrative Biology, 11(1): e1433440 [cover]
Slime mould: the fundamental mechanisms of biological cognition
Vallverdu, J., Castro, O., Mayne, R., Talanov, M., Levin, M., Baluska, F., Gunji, Y., Dussutour, A., Zenil, H., and Adamatzky, A., (2018)
BioSystems, 165: 57-70
Introducing Simulated Stem Cells into a Bio-Inspired Cell-Cell Communication Mechanism for Structure Regeneration
Ferreira, G. B. S., Scheutz, M., and Levin, M., (2018)
Proceedings of the 2017 IEEE Symposium Series on Computational Intelligence (SSCI), p. 2778-2785
2017
Ion channel and neurotransmitter modulators as electroceutical approaches to the control of cancer
Tuszynski, J., Tilli, T. M., and Levin, M., (2017)
Current Pharmaceutical Design, 23(32): 4827-4841
The brain is required for normal muscle and nerve patterning during early Xenopus development
Herrera-Rincon, C., Pai, V. P., Moran, K. M., Lemire, J. M., and Levin, M., (2017)
Nature Communications, 8(1): 587
Coordinating heart morphogenesis: A novel role for Hyperpolarization-activated cyclic nucleotidegated (HCN) channels during cardiogenesis in Xenopus laevis
Pitcairn, E., Harris, H., Epiney, J., Pai, V. P., Lemire, J. M., Ye, B., Shi, N-Q., Levin, M., and McLaughlin, K. A., (2017)
Communicative & Integrative Biology, 10(3): e1309488 [cover]
Bioelectric Signaling in Regeneration: Mechanisms of Ionic Controls of Growth and Form
McLaughlin, K. A., and Levin, M., (2017)
Developmental Biology, 433(2): 177–189
Bioelectric Gene and Reaction Networks: Computational Modeling of Genetic, Biochemical, and Bioelectrical Dynamics in Pattern Regulation
Pietak, A. M., and Levin, M., (2017)
J. Royal Society Interface, 14(134): 20170425 [cover]
Cancer as a Disorder of Patterning Information: computational and biophysical perspectives on the cancer problem
Moore, D., Walker, S., and Levin, M., (2017)
Convergent Science Physical Oncology, 3(4): 043001
HCN4 Ion Channel Function is Required for Early Events that Regulate Anatomical Left-Right Patterning in a Nodal- and Lefty Asymmetric gene Expression-Independent Manner
Pai, V. P., Willocq, V., Pitcairn, E. J., Lemire, J. M., Pare, J-F., Shi, N-Q., McLaughlin, K. A., and Levin, M., (2017)
Biology Open, 6(10): 1445-1457
Repeated removal of developing limb buds permanently reduces appendage size in the highly regenerative axolotl
Bryant, D. M., Sousounis, K., Farkas, J. E., Bryant, S., Thao, N., Guzikowski, A. R., Monaghan, J. R., Levin, M., and Whited, J. L., (2017)
Developmental Biology, 424(1): 1-9 [cover]
Using optogenetics in vivo to stimulate regeneration
Adams, D. S., Tseng. A-S., and Levin, M., (2017)
in K. Appasani (Ed.), Optogenetics: From Neuronal Function to Mapping and Disease Biology, Cambridge University Press: Cambridge, UK, p. 66-76
Investigating the Effects of Noise on a Cell-to-Cell Communication Mechanism for Structure Regeneration
Ferreira, G. B., Scheutz, M., and Levin, M., (2017)
in C. Knibbe, D. Parsons, D. Misevic, J. Rouzaud-Cornaba, N. Bredèche, S. Hassas, O. Simonin, and H. Soula. (Eds.), Proceedings of the 14th European Conference on Artificial Life (ECAL 2017), Lyon, France
The Zahn Drawings: new illustrations of Xenopus embryo and tadpole stages for studies of craniofacial development
Zahn, N., Levin, M., and Adams, D. S., (2017)
Development, 144(15): 2708-2713 [cover]
Microfluidic Platform to Study Intercellular Connectivity Through on-Chip Electrical Impedance Measurement
Dungan, J., Mathews, J., Levin, M., and Koomson, V., (2017)
IEEE 60th International Midwest Symposium on Circuits and Systems, Boston, MA, p.56-69 doi: 10.1109/MWSCAS.2017.8052859
Bioelectric regulation of innate immune system function in regenerating and intact Xenopus laevis
Pare, J-F., Martyniuk, C. J., and Levin, M., (2017)
npj Regenerative Medicine, 2:15
Long-Term, Stochastic Editing of Regenerative Anatomy via Targeting Endogenous Bioelectric Gradients
Durant, F., Morokuma, J., Fields, C., Williams, K., Adams, D. S., and Levin, M., (2017)
Biophysical Journal, 112(10): 2231-2243 [cover]
Space travel has effects on planarian regeneration that cannot be explained by a null hypothesis
Levin, M., Morokuma, J., and Finkelstein, J, (2017)
Regeneration, 4(4): 156-158
Planarian regeneration in space: persistent anatomical, behavioral, and bacteriological changes induced by space travel
Morokuma, J., Durant, F. R., Williams, K. B., Finkelstein, J. M., Blackiston, D. J., Clements, T., Reed, D. W., Roberts, M., Jain, M., Kimel, K., Trayger, S. A., Wolfe, B. E., and Levin, M., (2017)
Regeneration, 4(2): 85-102 [cover]
Gap Junctional Signaling in Pattern Regulation: physiological network connectivity instructs growth and form
Mathews, J., and Levin, M., (2017)
Developmental Neurobiology, 77(5): 643-673
Endogenous Bioelectric Signaling Networks: Exploiting Voltage Gradients for Control of Growth and Form
Levin, M., Pezzulo, G., and Finkelstein, J. M., (2017)
Annual Review of Biomedical Engineering, 19: 353-87
IK channel activation increases tumor growth and induces differential behavioral responses in two breast epithelial cell lines
Thurber, A. E., Nelson, M., Frost, C. L., Levin, M., Brackenbury, W. J., and Kaplan, D. L., (2017)
Oncotarget, 8(26): 42382-42397
Serotonergic stimulation induces nerve growth and promotes visual learning via posterior eye grafts in a vertebrate model of induced sensory plasticity
Blackiston, D., Vien, K., and Levin, M., (2017)
npj Regenerative Medicine, 2:8
Discovering novel phenotypes with automatically inferred dynamic models: partial melanocyte conversion in Xenopus
Lobo, D., Lobikin, M., and Levin, M., (2017)
Scientific Reports, 7: 41339
Reversals of bodies, brains, and behavior: quantitative analysis of laterality and its disturbance in model species
Blackiston, D. J., and Levin, M., (2017)
in L. J. Rogers and G. Vallortigara (Eds.), Lateralized Brain Functions: Methods in Human and Non-human Species, "Neuromethods", W. Walz (Ed.), 122: 667-694
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Modeling regenerative processes with Membrane Computing
Garcia-Quismondo, M., Levin, M., and Lobo, D., (2017)
Information Sciences, 381: 229-249
2016
Levin, M., and Adams, D. S., (2016)
Ahead of the Curve: Hidden Breakthroughs in the Biosciences, Vol. 1, IOP Publishing: Bristol, UK [cover]
Introduction to provocative questions in Left-Right asymmetry
Levin, M., Klar, A. J. S., Ramsdell, A., (2016)
Philosophical Transactions B, 371: 20150399
From cytoskeletal dynamics to organ asymmetry: a nonlinear, regulative pathway underlies left-right patterning
McDowell, G., Rajadurai, S., and Levin, M., (2016)
Philosophical Transactions B, 371: 20150409
Top-down models in biology: explanation and control of complex living systems above the molecular level
Pezzulo, G., and Levin, M., (2016)
Journal of the Royal Society Interface, 13: 20160555 [cover]
Bioelectrical coordination of cell activity toward anatomical target states: an engineering perspective on regeneration
Herrera-Rincon, C., Guay, J., and Levin, M., (2016)
Chapter 4 in D. Gardiner (Ed.), Regenerative Engineering and Developmental Biology: Principles and Applications, CRC Press: Boca Raton, FL, p. 55-112
Vertically and horizontally-transmitted memories – the fading boundaries between regeneration and inheritance in planaria
Neuhof, M., Levin, M., and Rechavi, O., (2016)
Biology Open, 5, 1177-1188 [cover]
Dynamic structure discovery and repair for 3D cell assemblages
Ferreira, G., Smiley, M., Scheutz, M., and Levin, M., (2016)
Proceedings of the Fifteenth International Conference on the Synthesis and Simulation of Living Systems (ALIFEXV), p. 352-359
A Level Set Approach to Simulating Xenopus laevis Tail Regeneration
Serlin, Z., Rife, J., and Levin, M., (2016)
Proceedings of the Artificial Life Conference 2016, p. 528-535
Exploring Instructive Physiological Signaling with the Bioelectric Tissue Simulation Engine (BETSE)
Pietak, A., and Levin, M., (2016)
Frontiers in Bioengineering and Biotechnology, 4(55): doi 10.3389/fbioe.2016.00055
On Having No Head: Cognition throughout Biological Systems
Baluska, F., and Levin, M., (2016)
Frontiers in Psychology, 7: 902, doi: 10.3389/fpsyg.2016.00902
A Tunable Silk Hydrogel Device for Studying Limb Regeneration in Adult Xenopus laevis
Golding, A., Guay, J. A., Herrera-Rincon, C., Levin, M., and Kaplan, D. L., (2016)
PLoS One 11, e0155618
Physiological Inputs Regulate Species-Specific Anatomy During Embryogenesis and Regeneration
Sullivan, K. G., Emmons-Bell, M., and Levin, M., (2016)
Communicative and Integrative Biology, 9:4, e1192733 [cover]
Computational discovery and in vivo validation of hnf4 as a regulatory gene in planarian re-generation
Lobo, D., Morokuma, J., and Levin, M., (2016)
Bioinformatics, 32(17): 2681-2685
A Computational Model of Planarian Regeneration
De, Abhishek, Chakravarthy, V. Srinivasa , and Levin, M., (2016)
International Journal of Parallel, Emergent, and Distributed Systems, 32(4): 331-347
Color and intensity discrimination in Xenopus laevis tadpoles
Rothman, G., Blackiston, D., and Levin, M., (2016)
Animal Cognition, 19:911-919
Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog
Davison A., McDowell G. S., Holden, J. M., Johnson H. F., Koutsovoulos G. D., Liu M. M., Hulpiau P., Van Roy F., Wade C. W., Banerjee R., Yang F., Chiba S., Davey J. W., Jackson, D. J., Levin M., and Blaxter, M. L., (2016)
Current Biology, 26(5): 654-60 [cover]
Telocytes in their context with other intercellular communication agents
Edelstein, L., Fuxe, K., Levin, M., Popescu, B., and Smythies, J., (2016)
Seminars in Cell and Developmental Biology, 55:9–13
Physiological controls of large-scale patterning in planarian regeneration: a molecular and computational perspective on growth and form
Durant, F., Lobo, D., Hammelman, J., and Levin, M., (2016)
Regeneration, 3(2): 78-102 [cover]
Use of genetically encoded, light-gated ion translocators to control tumorigenesis
Chernet, B. T., Adams, D. S., Lobikin, M., and Levin, M., (2016)
Oncotarget, 7(15): 19575-19588
Neurotransmitter signaling pathways required for normal development in Xenopus laevis embryos: a pharmacological survey screen
Sullivan, K. G., and Levin, M., (2016)
Journal of Anatomy, 229: 483-502 [cover]
Bioelectric modulation of macrophage polarization
Li, C., Levin, M., and Kaplan, D., (2016)
Scientific Reports, 6:21044, doi:10.1038/srep21044
Bioelectric signaling via potassium channels: a mechanism for craniofacial dysmorphogenesis in KCNJ2-associated Andersen-Tawil Syndrome
Adams, D. S., Uzel, S. G. M., Akagi, J., Wlodkowic, D., Andreeva, V., Yelick, P. C., Devitt-Lee, A., Pare, J-F., and Michael Levin, (2016)
Journal of Physiology, 12: 3245-3270 [cover]
On chirality of slime mould
Dimonte, A., Adamatzky, A., Erokhin, V., (2016)
BioSystems, 140: 23-27
Conserved roles for cytoskeletal components in determining laterality
McDowell, G. S., Lemire, J. M., Pare, J-F., Cammarata, G., Lowery, L. A., and Levin, M., (2016)
Integrative Biology, 8: 267-286. DOI: 10.1039/C5IB00281H [cover]
MoCha: molecular characterization of unknown pathways
Lobo, D., Hammelman, J., and Levin, M., (2016)
Journal of Computational Biology, 23(4): 291-297
Towards a physarum learning chip
Whiting, J. G. H., Jones, J., Bull, L., Levin, M., and Adamatzky, A., (2016)
Scientific Reports, 6:19948 (1-14)
Computing a worm: reverse-engineering planarian regeneration
Lobo, D., and Levin, M., (2016)
Advances in Unconventional Computing, Andrew Adamatzky ed., Vol. 2, Springer, p. 637-654
Artificial neural networks as models of robustness in development and regeneration: stability of memory during morphological remodeling
Hammelman, J., Lobo, D., and Levin, M., (2016)
in Artificial Neural Network (ANN) Modeling, S. Shanmuganathan and S. Samarasinghe (Eds.) , p. 45-65
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2015
Comparison of the depolarization response of human mesenchymal stem cells from different donors
Sundelacruz, S., Levin M., and Kaplan, D. L., (2015)
Scientific Reports, 5: 18279 (doi: 10.1038/srep18279)
Gap junctional blockade stochastically induces different species-specific head anatomies in genetically wild-type Girardia dorotocephala flatworms
Emmons-Bell, M., Durant, F., Hammelman, J., Bessonov, N., Volpert, V., Morokuma, J., Pinet, K., Adams, D. S., Pietak, A., Lobo, D., and Levin, M., (2015)
International Journal of Molecular Sciences, 16: 27865–27896 [cover]
Automatic neuron segmentation and neural network analysis method for phase contrast microscopy images
Pang, J., Ozkucur, N., Ren, M., Kaplan, D. L., Levin, M., and Miller, E. L., (2015)
Biomedical Optics Express, 6(11) 4395-4416
Re-membering the body: applications of computational neuroscience to the top-down control of regeneration of limbs and other complex organs
Pezzulo, G., and Levin, M., (2015)
Integrative Biology, 7: 1487-1517 [cover]
Serotonergic regulation of melanocyte conversion: A bioelectrically regulated network for stochastic all-or-none hyperpigmentation
Lobikin, M., Lobo, D., Blackiston, D. J., Martyniuk, C. J., Tkachenko, E., and Levin, M., (2015)
Science Signaling, 8(397): ra99
Bioelectric memory: modeling resting potential bistability in amphibian embryos and mammalian cells
Law, R., and Levin, M., (2015)
Theoretical Biology and Medical Modelling, 12: (1): 22
Genome-wide analysis reveals conserved transcriptional responses downstream of resting potential change in Xenopus embryos, axolotl regeneration, and human mesenchymal cell differentiation
Pai, V. P., Martyniuk, C. J., Echeverri, K., Sundelacruz, S., Kaplan, D. L., and Levin, M., (2015)
Regeneration, 3(1): 3-25
H+/K+-ATPase activity is required for biomineralization in sea urchin embryos
Schatzberg, D., Lawtn, M., Hadyniak S. E., Ross E. J., Carney T., Beane W. S., Levin, M., and Bradham, C. A., (2015)
Developmental Biology, 406(2): 259-270
Target morphology and cell memory: a model of regenerative pattern formation
Bessonov, N., Levin, M., Morozova, N., Reinberg, N., Tosenberger, A., Volpert, V., (2015)
Neural Regeneration Research, 10(12): 1901-1905 [cover]
Inferring regulatory networks from experimental morphological phenotypes: a computational method reverse-engineers planarian regeneration
Lobo, D., and Levin, M., (2015)
PLoS Computational Biology, 11(6): e1004295
The Stability of Memories During Brain Remodeling: a Perspective
Blackiston, D. J., Shomrat, T., and Levin, M., (2015)
Communicative and Integrative Biology, 8(5): e1073424 [cover]
A conceptual model of morphogenesis and regeneration
Tosenberger, A., Bessonov, N., Levin, M., Reinberg, N., Volpert, V., Morozova, N., (2015)
Acta Biotheoretica, 63: 283-294
Local and long-range endogenous resting potential gradients antagonistically regulate apoptosis and proliferation in the embryonic CNS
Pai, V. P., Lemire J. M., Chen Y., Lin G., and Levin M., (2015)
International Journal of Developmental Biology, 59: 327-340 (2015) [cover]
Selective Depolarization of Transmembrane Potential Alters Muscle Patterning and Muscle Cell Localization in Embryonic Xenopus Laevis
Lobikin, M., Pare, J-F., Kaplan, D. L., and Levin, M., (2015)
International Journal of Developmental Biology, 59: 303-311 (2015) [cover]
'Knowing one's place' a free energy approach to pattern regulation
Friston, K., Levin, M., Sengupta B., and Pezzulo, G., (2015)
Journal of the Royal Society Interface, 12: 20141383
Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation
Pai, V., Lemire, J. M., Pare, J-F., Lin, G., Chen, Y., and Levin, M., (2015)
Journal of Neuroscience, 35(10): 4366-4385
Membrane potential depolarization causes alterations in neuron arrangement and connectivity in cocultures
Özkucur, N., Quinn, K. P., Pang, J. C., Du, C., Georgakoudi, I., Miller, E., Levin, M., and Kaplan, D. L., (2015)
Brain and Behavior, 5(1): 24-38
On a model of pattern recognition based on cell memory
Bessonov, N., Levin, M., Morozova, N., Reinberg, N., Tosenberger, A., and Volpert, V., (2015)
PLoS One, 10(2): e0118091
A novel method for inducing nerve growth via modulation of host resting potential
Blackiston, D., Anderson, G. M., Rahman, N., Bieck, C., and Levin, M., (2015)
Neurotherapeutics, 12: 170-184
Long-range gap junctional signaling controls oncogene-mediated tumorigenesis in Xenopus laevis embryos
Chernet, B. T., Fields, C., and Levin, M., (2015)
Frontiers in Physiology, 5(519); 1-15, doi: 10.3389/fphys.2014.00519
2014
Molecular bioelectricity: how endogenous voltage potentials control cell behavior and instruct pattern regulation in vivo
Levin, M., (2014)
Molecular Biology of the Cell, 25(24): 3835-3850
Optogenetic Control of Apoptosis in Targeted Tissues of Xenopus laevis Embryos
Jewhurst, K., Levin, M., and McLaughlin, K. A., (2014)
Journal of Cell Death, 7: 25-31
Optogenetics in developmental biology: using light to control ion flux-dependent signals in Xenopus embryos
Adams, D.S., Lemire, J. M., Kramer, R. H., and Levin, M., (2014)
International Journal of Developmental Biology, 58(10-12): 851-861
Left-right patterning in Xenopus conjoined twin embryos requires serotonin signaling and gap junctions
Vandenberg, L. N., Blackiston, D. J., Rea, A. C., Dore, T. M., and Levin, M., (2014)
International Journal of Developmental Biology, 58(10-12): 799-809
Fishing on chips: up-and-coming technological advances in analysis of zebrafish and Xenopus embryos
Zhu, F., Skommer, J., Huang, Y., Akagi, J., Adams, D. S., Levin, M., Hall, C. J., Crosier, P. S., and Wlodkowic, D., (2014)
Cytometry A, 85A: 921-932
Limbform: a functional ontology-based database of limb regeneration experiments
Lobo, D., Feldman, E. B., Shah, M., Malone, T. J., and Levin, M., (2014)
Bioinformatics, 30(24): 3598-3600
Depolarization of Cellular Resting Membrane Potential Promotes Neonatal Cardiomyocyte Proliferation In Vitro
Lan J. Y., Williams C., Levin M., and Black L. D. III, (2014)
Cellular and Molecular Bioengineering, 7(3): 432-445
Bioelectrical mechanisms for programming growth and form: taming physiological networks for soft body robotics
Mustard, J., and Levin, M., (2014)
Soft Robotics, 1(3): 169-191
A bioinformatics expert system linking functional data to anatomical outcomes in limb regeneration
Lobo, D., Feldman, E. B., Shah, M., Malone, T., and Levin, M., (2014)
Regeneration, 1(2): 37-56
Design of a flexible component gathering algorithm for converting cell-based models to graph representations for use in evolutionary search
Budnikova, M., Habig, J. W., Cornia, N., Levin. M., Lobo, D., and Andersen, T., (2014)
BMC Bioinformatics, 15: 178, doi: 10.1002/reg2.13
Transmembrane voltage potential of somatic cells controls oncogene-mediated tumorigenesis at long-range
Chernet, B., and Levin, M., (2014)
Oncotarget, 5(10): 3287-3306 [cover]
Alteration of bioelectrically controlled processes in the embryo: a teratogenic mechanism for anticonvulsants
Hernandez-Diaz S., and Levin, M., (2014)
Reproductive Toxicology, 47: 111-114
Bioelectric controls of stem cell function
Pai, V., and Levin, M., (2014)
Chapter 5 in F. Calegari and C. Waskow (Eds.), Stem Cells: From Basic Research to Therapy, Volume 1, CRC Press: Boca Raton, FL, p. 106-145
Endogenous bioelectrical networks store non-genetic patterning information during development and regeneration
Levin, M., (2014)
Journal of Physiology, 592(11): 2295–2305
A linear-encoding model explains the variability of the target morphology in regeneration
Lobo, D., Solano, M., Bubenik, G. A., and Levin, M., (2014)
Journal of the Royal Society Interface, 11(92): 20130918
Endogenous bioelectric cues as morphogenetic signals in vivo
Lobikin, M., and Levin, M., (2014), ,
Chapter 15 in D. Fels, M. Cifra, and F. Scholkmann (Eds), Fields of the Cell, Research Signpost: Kerala, India p. 283-302
2013
It's Never Too Early to Get It Right: A Conserved Role for the Cytoskeleton in Left-Right Asymmetry
Vandenberg, L. N., Lemire, J. M, and Levin, M., (2013)
Communicative & Integrative Biology, 6(6): e27155
Rab GTPases are required for early orientation of the left-right axis in Xenopus
Vandenberg, L. N., Morrie, R. D., Seebohm, G., Lemire, J. M., and Levin, M., (2013)
Mechanisms of Development, 130(4-5): 254-271 [cover]
Light-activated serotonin for exploring its action in biological systems
Rea, A. C., Vandenberg, L. N., Ball, R. E., Snouffer, A. A., Hudson, A. G., Zhu, Y., McLain, D. E., Johnston, L. L., Lauderdale J. D., Levin, M., and Dore, T. M., (2013)
Chemistry & Biology, 20(12): 1536–1546
Bioelectric modulation of wound healing in a 3D in vitro model of tissue-engineered bone
Sundelacruz, S., Li, C., Choi, Y. J., Levin, M., and Kaplan, D. L., (2013)
Biomaterials, 34(28): 6695-705
Depolarization Alters Phenotype, Maintains Plasticity of Predifferentiated Mesenchymal Stem Cells
Sundelacruz, S., Levin, M., and Kaplan, D. L., (2013)
Tissue Engineering Part A, 19 (17-18): 1889-1908
Endogenous voltage potentials and the microenvironment: bioelectric signals that reveal, induce, and normalize cancer
Chernet, B., and Levin, M., (2013)
Journal of Clinical and Experimental Oncology, S1: doi:10.4172/2324-9110.S1-002 [cover]
Reprogramming cells and tissue patterning via bioelectrical pathways: molecular mechanisms and biomedical opportunities
Levin, M., (2013), , Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 5(6): 657-676
An automated training paradigm reveals long-term memory in planaria and its persistence through head regeneration
Shomrat, T., and Levin, M., (2013), ,
Journal of Experimental Biology, 216(20): 3799-3810
Endogenous Voltage Gradients as Mediators of Cell-Cell Communication: Strategies for Investigating Bioelectrical Signals During Pattern Formation
Adams, D. S., and Levin, M., (2013)
Cell and Tissue Research, 352(1):95-122 [cover]
Bioelectrical signaling has rich history
Levin, M., (2013)
Physics Today, 66(9): 11
Towards a bioinformatics of patterning: a computational approach to understanding regulative morphogenesis
Lobo, D., Malone, T. J., and Levin, M., (2013)
Biology Open, 2(2): 156-169 [cover]
Inversion of left-right asymmetry alters performance of Xenopus tadpoles in nonlateralized cognitive tasks
Blackiston, D. J., and Levin, M., (2013)
Animal Behaviour, 86(2): 459-466
A unified model for left-right asymmetry? Comparison and synthesis of molecular models of laterality
Vandenberg, L. N., and Levin, M., (2013)
Developmental Biology, 379(1): 1-15 [cover]
Ectopic eyes outside the head in Xenopus tadpoles provide sensory data for light-mediated learning
Blackiston, D. J., and Levin, M., (2013)
Journal of Experimental Biology, 216(6): 1031-1040
Planform: an application and database of graph-encoded planarian regenerative experiments
Lobo, D., Malone, T.J., and Levin, M., (2013)
Bioinformatics, 29(8): 1098-1100
Humane anesthesia and pain management in amphibian limb surgery of Rana pipiens
Koustubhan, P., Kaplan, D., and Levin, M., (2013)
Cold Spring Harbor Protocols, 2013(2): 149 [cover]
Transmembrane voltage potential is an essential cellular parameter for the detection and control of tumor development
Chernet, B. T., and Levin, M., (2013)
Disease Models & Mechanisms, 6(3): 595-607
Cracking the bioelectric code: probing endogenous ionic controls of pattern formation
Tseng, A-S., and Levin, M., (2013)
Communicative & Integrative Biology, 6(1): e22595 [cover]
Light-activation of the Archaerhodopsin H+ pump reverses age-dependent loss of vertebrate regeneration: sparking system-level controls in vivo
Adams, D. S., Tseng, A-S. and M. Levin, (2013)
Biology Open, 2(3): 306-313
Serotonin has early, cilia-independent roles in Xenopus left-right patterning
Vandenberg, L. N., Lemire, J. M., and M. Levin, (2013)
Disease Models and Mechanisms, 6(1): 261-268 [cover]
Bioelectric signaling regulates head and organ size during planarian regeneration
Beane, W. S., Morokuma, J., Lemire, J. M., and Levin, M., (2013)
Development, 140(2): 313-322
2012
Low frequency vibrations induce malformations in two aquatic species in a frequency-, waveform-, and direction-specific manner
Vandenberg, L. N., Stevenson, C., and M. Levin, (2012)
PLoS One, 7(12): e51473
Neurally derived tissues in Xenopus laevis embryos exhibit a consistent bioelectrical left-right asymmetry
Pai, V. P., Vandenberg, L. N., Blackiston, D. J., and Levin, M., (2012)
Stem Cells International, 2012: 353491, doi:10.1155/2012/353491
Resting potential, oncogene-induced tumorigenesis, and metastasis: the bioelectric basis of cancer in vivo
Lobikin, M., Chernet, B., Lobo, D., and Levin, M., (2012)
Physical Biology, 9(6): 065002 [cover]
Early nonciliary role for microtubule proteins in left–right patterning is conserved across kingdoms
Lobikin, M., Wang, G., Xu, J.-S., Hsieh, Y.-W., Chuang, C.-F., Lemire, J. M., and M. Levin, (2012)
Proceedings of the National Academy of Sciences of the United States, 109(31): 12586-12591
Transducing bioelectrical signals into epigenetic pathways during tadpole tail regeneration
Tseng, A.-S., and Levin, M., (2012)
Anatomical Record, 295(10): 1541-1551
Photoconversion for Tracking the Dynamics of Cell Movement in Xenopus laevis Embryos
Chernet, B. T., Adams, D. S., and Levin, M., (2012)
Cold Spring Harbor Protocols, 2016(6): 683-690 [cover]
Morphogenetic fields in embryogenesis, regeneration, and cancer: non-local control of complex patterning
Levin, M., (2012)
BioSystems, 109(3): 243-261
Normalized shape and location of perturbed craniofacial structures in the Xenopus tadpole reveal an innate ability to achieve correct morphology
Vandenberg, L.N., Adams, D. S., and Levin, M., (2012)
Developmental Dynamics, 241(5): 863-878 [cover]
Aversive training methods in Xenopus laevis: general principles
Blackiston, D. J., and Levin, M., (2012)
Cold Spring Harbor Protocols, 2012(5): 521-527
Inhibition of planar cell polarity extends neural growth during regeneration, homeostasis, and development
Beane, W. S., Tseng, A.-S., Morokuma, J. M., Lemire, J. M., and Levin, M., (2012)
Stem Cells and Development, 21(12): 2085-2094 [cover]
A versatile protocol for mRNA electroporation of Xenopus laevis embryos
Chernet, B. T., and Levin, M., (2012)
Cold Spring Harbor Protocols, 2012(4): 447-452
General principles for measuring resting membrane potential and ion concentration using fluorescent bioelectricity reporters
Adams, D. S., and Levin, M., (2012)
Cold Spring Harbor Protocols, 2012(4): 385-397 [cover]
Measuring resting membrane potential using the fluorescent voltage reporters DiBAC4(3) and CC2-DMPE
Adams, D. S., and M. Levin, (2012)
CSHL Protocols, doi: 10.1101/pdb.prot067702
Transmembrane voltage potential controls embryonic eye patterning in Xenopus laevis
Pai, V., Aw, S., Shomrat, T., Lemire, J. M., and Levin, M., (2012)
Development, 139(2): 313-323
Molecular bioelectricity in developmental biology: new tools and recent discoveries
Levin, M., (2012)
BioEssays, 34(3): 205-217 [cover]
Polarity proteins are required for left-right axis orientation and twin-twin instruction
Vandenberg, L. N., and Levin, M., (2012)
Genesis, 50(3): 219-234
Regulation of Cell Behavior and Tissue Patterning by Bioelectrical Signals: challenges and opportunities for biomedical engineering
Levin, M., and Stevenson, C., (2012)
Annual Reviews in Biomedical Engineering, 14: 295-323
Modeling planarian regeneration: a primer for reverse-engineering the worm
Lobo, D., Beane, W., and Levin, M., (2012)
PLoS Computational Biology, 8(4): e1002481 [cover]
2011
A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration
Beane, W. S., Morokuma, J., Adams, D. S., and Levin, M., (2011)
Chemistry & Biology, 18(1): 77-89
The H(+) vacuolar ATPase maintains neural stem cells in the developing mouse cortex
Lange, C., Prenninger, S., Knuckles, P., Taylor, V., Levin, M., and Calegari, F., (2011)
Stem Cells and Development, 20(5): 843-850
Histone deacetylase activity is necessary for left-right patterning during vertebrate development
Carneiro, K., Donnet, C., Rejtar, T., Karger, B. L., Díaz, E., Kortagere, S., Lemire, J. M., and Levin, M. (2011)
BMC Developmental Biology, 11: 29
Transmembrane potential of GlyCl-expressing instructor cells induces a neoplastic-like conversion of melanocytes via a serotonergic pathway
Blackiston, D., Adams, D. S., Lemire, J. M., Lobikin, M., and Levin, M., (2011)
Disease Models and Mechanisms, 4(1): 67-85 [cover]
Low-frequency vibrations disrupt left-right patterning in the Xenopus embryo
Vandenberg, L. N., Pennarola, B. W., and Levin, M., (2011)
PLoS One, 6(8): e23306
Patterned femtosecond-laser ablation of Xenopus laevis melanocytes for studies of cell migration, wound repair, and developmental processes
Mondia, J. P., Adams, D. S., Orendorff, R. D., Levin, M., and Omenetto, F., (2011)
Biomedical Optics Express, 2(8): 2383-2391
Long-distance signals are required for morphogenesis of the regenerating Xenopus tadpole tail
Mondia, J. P., Levin, M., Omenetto, F. G., Orendorff, R. D., Branch, M. R., and Adams, D. S., (2011)
PLoS One, 6(9): e24953
HDAC activity is required during Xenopus tail regeneration
Tseng, A-S., Carneiro, K., Lemire, J. M., and Levin, M., (2011)
PLoS One, 6(10): e26382
Endogenous bioelectrical signals in development, regeneration, and neoplasm
Levin, M. (2011)
in Topical Talks: The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London.
Left-Right Asymmetry in Embryonic Development: How epigenetic, biophysical forces and gene activity interplay to determine a major embryonic axis
Levin, M. (2011), ,
in Topical Talks: The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London.
Endogenous Bioelectric Signals as Morphogenetic Controls of Development, Regeneration, and Neoplasm
Levin, M., (2011)
in The Physiology of Bioelectricity in Development, Tissue Regeneration, and Cancer, C. Pullar (Ed.), CRC Press: Boca Raton, FL, p. 39-89
The wisdom of the body: future techniques and approaches to morphogenetic fields in regenerative medicine, developmental biology, and cancer
Levin, M., (2011)
Regenerative Medicine, 6(6): 667-673
2010
A second-generation device for automated training and quantitative behavior analyses of molecularly tractable model organisms
Blackiston, D., Shomrat, T., Nicolas, C. L., Granata, C., and Levin, M., (2010)
PLoS One, 5(12): e14370
Long-range Neural and Gap Junction Protein-mediated Cues Control Polarity During Planarian Regeneration
Oviedo, N. J., Morokuma, J., Walentek, P., Kema, I. P., Gu, M. B., Ahn, J. M., Hwang, J. S., Gojobori, T., and Levin, M., (2010)
Developmental Biology, 339: 188-199
Consistent left-right asymmetry cannot be Established by late organizers in Xenopus unless the late organizer is a conjoined twin
Vandenberg, L. N., and M. Levin, (2010)
Development, 137, 1095-1105 [cover]
The ATP-sensitive K+-channel (KATP) controls early left-right patterning in Xenopus and chick embryos
Aw, S., Koster, J., Pearson, W., Nicols, C., Shi, N. Q., Carneiro, K., and Levin, M., (2010)
Developmental Biology, 346: 39-53
Induction of vertebrate regeneration by a transient sodium current
Tseng, A-S., Beane, W. S., Lemire, J. M., Masi, A., and M. Levin, (2010)
Journal of Neuroscience, 30(39): 13192-13200 [cover]
BioDome regenerative sleeve for biochemical and biophysical stimulation of tissue regeneration
Hechavarria, D., Dewilde, A., Braunhut, S., Levin, M., and Kaplan, D. K., (2010)
Medical Engineering and Physics, 32: 1065-1073
High-throughput Xenopus laevis immunohistochemistry using agarose sections
Blackiston, D., Vandenberg, L. N., and Levin, M., (2010)
Cold Spring Harbor Protocols, doi:10.1101/pdb.prot5532
Far from solved: a perspective on what we know about early mechanisms of left-right asymmetry
Vandenberg, L. N., and Levin, M., (2010)
Developmental Dynamics, 239: 3131-3146 [cover]
2009
Is left-right asymmetry a form of planar cell polarity?
Aw, S., and Levin, M., (2009)
Development, 136: 355-366
Perspectives and open problems in the early phases of left-right patterning
Vandenberg, L., and Levin, M., (2009)
Seminars in Cell and Developmental Biology, 20: 456-463 [cover]
Particle tracking model of electrophoretic morphogen movement reveals stochastic dynamics of embryonic gradient
Zhang, Y., and M. Levin, (2009)
Developmental Dynamics, 238(8): 1923-1935
Left-right asymmetry in the chick embryo requires core planar cell polarity protein Vangl2
Zhang, Y., and M. Levin, (2009)
Genesis, 47(11): 719-728
Bioelectric mechanisms in regeneration: Unique aspects and future perspectives
Levin, M. (2009)
Seminars in Cell and Developmental Biology, 20: 543-556
Bioelectric controls of cell proliferation: ion channels, membrane voltage, and the cell cycle
Blackiston, D. J., K. McLaughlin, and Levin, M., (2009)
Cell Cycle, 8(21): 3527-3536 [cover]
Errors of Geometry: regeneration in a broader perspective
Levin, M., (2009)
Seminars in Cell and Developmental Biology, 20(6): 643-645
Regeneration: recent advances, major puzzles, and biomedical opportunities
Levin, M., (2009)
Seminars in Cell and Developmental Biology, 20(5): 515-516
Role of membrane potential in the regulation of cell proliferation and differentiation
Levin, M., Sundelacruz, S., Levin M., Kaplan, D. L., (2009)
Stem Cell Reviews, 5(3): 231-46
2008
KCNQ1 and KCNE1 K+ channel components are involved in early left-right patterning in Xenopus embryos
Morokuma, J., Blackiston, D., and Levin, M., (2008)
Cellular Physiology and Biochemistry, 21: 357-372
Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling
Oviedo, N. J., B. J. Pearson, M. Levin, and A. S. Alvarado, (2008)
Disease Models and Mechanisms, 1: 131-143
Modulation of potassium channel confers a hyper-proliferative invasive phenotype on embryonic stem cells
Morokuma, J., Blackiston, D., Adams, D. S., Seebohm, G., Trimmer, B., and Levin, M., (2008)
Proceedings of the National Academy of Sciences of the United States, 105(43): 16608-16613
Membrane potential controls adipogenic and osteogenic differentiation of mesenchymal stem cells
Sundelacruz, S., M. Levin, and D. L. Kaplan, (2008)
PLoS One, 3(11): e3737, 1-15
Live imaging of planarian membrane potential using DiBAC4(3)
Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M., (2008)
Cold Spring Harbor Protocols, doi:10.1101/pdb.prot5055
Gene knockdown in planarians using RNA interference
Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M., (2008)
Cold Spring Harbor Protocols, doi:10.1101/pdb.prot5054
Establishing and maintaining a colony of planarians
Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M., (2008)
Cold Spring Harbor Protocols, doi:10.1101/pdb.prot5053
Planarian regeneration model as a context for the study of drug effects and mechanisms
Oviedo, N., and Levin, M., (2008)
in Planaria: A Model for Drug Action and Abuse, R. B. Raffa & S.M. Rawls (Eds.), RG Landes Co.: Austin, p. 95-104
Analysis of behavior in the planarian model
Nicolas, C.L., Abramson, C.I., and Levin, M. (2008), ,
in Planaria: A Model for Drug Action and Abuse, R. B. Raffa & S.M. Rawls (Eds.), RG Landes Co.: Austin, p. 83-94
What's Left in Asymmetry?
Aw, S., and Levin, M., (2008)
Developmental Dynamics, 237: 3453-3464
Planarians: a versatile and powerful model system for molecular studies of regeneration, adult stem cell regulation, aging, and behavior
Oviedo, N., Nicolas, C. L., Adams, D. S., and Levin, M. (2008), ,
in Emerging Model Organisms: A Laboratory Manual, Volume 1, Cold Spring Harbor Press: Cold Spring Harbor, NY
Tail regeneration in Xenopus laevis as a model for understanding tissue repair
Tseng, A-S., and Levin, M., (2008)
Journal of Dental Research, 87(9): 806-816
2007
Apoptosis is required during early stages of tail regeneration in Xenopus laevis
Tseng, A-S., Adams, D. S., Qiu, D., Koustubhan, P., and Levin, M. (2007)
Developmental Biology, 301: 62-69
H+ Pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration
Adams, D. S., Masi, A., and Levin, M. (2007)
Development, 134: 1323-1335 [cover]
smedxin-11 is a Planarian Stem Cell Gap Junction Gene Required for Regeneration and Homeostasis
Oviedo, N. J., Levin, M., (2007)
Development, 134(17): 3121-3131
H,K-ATPase protein Localization and Kir4.1 function reveal concordance of three axes during early determination of left-right asymmetry
Aw, S., Adams, D. S., Qiu, D., and Levin, M., (2007)
Mechanisms of Development, 125: 353-372
Establishing and maintaining a Xenopus laevis colony for research laboratories
Koustubhan, P., Sorocco, D., and Levin, M., (2007)
in M. Conn (Ed.), Source Book of Models for Biomedical Research, Humana Press, p. 139-160
Left-right patterning from the inside out: widespread evidence for intracellular control
Levin, M., Palmer, R., (2007)
BioEssays, 29: 271-287
Gap junctional communication in morphogenesis
Levin, M., (2007)
Progress in Biophysics and Molecular Biology, 94 (1-2): 186-206
Large-Scale Biophysics: Ion Flows and Regeneration
Levin, M., (2007)
Trends in Cell Biology, 17(6): 261-270 [cover]
What lies at the interface of regenerative medicine and developmental biology?
Ingber, D., and Levin, M. (2007)
Development, 134: 2541-2547
Gap junctions provide new links in Left-Right patterning
Oviedo, N., and Levin, M. (2007)
Cell, 129: 645-647
2006
Ion flow regulates left-right asymmetry in sea urchin development
Hibino, T., Ishii, Y., Levin, M., and Nishino, A., (2006)
Development, Genes and Evolution, 216(5): 265-76
Evidence for the regulation of left-right asymmetry in Ciona intestinalis by ion flux
Shimeld, S. M., and Levin, M., (2006)
Developmental Dynamics, 235(6): 1543-1553
Early, H+-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates
Adams, D. S., Robinson, K. R., Fukumoto, T., Yuan, S., Albertson, R. C., Yelick, P., Kuo, L., McSweeney, M., and Levin M., (2006)
Development, 133: 1657-1671
Automated Analysis of Behavior: A Computer-Controlled System for Drug Screening and the Investigation of Learning
Hicks, C., Sorocco, D., and Levin, M., (2006)
Journal of Neurobiology, 66(9): 977-90
Mathematical Model of Morphogen Electrophoresis through Gap Junctions
Esser, A. T., Smith, K. C., Weaver, J. C., and Levin, M., (2006)
Developmental Dynamics, 235(8): 2144-2159
Inverse Drug Screens: a rapid and inexpensive method for implicating molecular targets
Adams, D. S., and Levin, M., (2006)
Genesis, 44: 530-540
Strategies and techniques for investigation of biophysical signals in patterning
Adams, D., and Levin, M., (2006)
in Analysis of Growth Factor signaling in Embryos, M. Whitman and A. K. Sater eds., pp. 177-264, Methods in Signal Transduction Series, CRC Press
Of Minds and Embryos: Left-Right Asymmetry and the Serotonergic Controls of Pre-Neural Morphogenesis
Levin, M., Lauder, J., and Buznikov, G., (2006)
Developmental Neuroscience, 28:171-185 [cover]
Is the Early Left-Right Axis like a Plant, a Kidney, or a Neuron? The Integration of Physiological Signals in Left-Right Asymmetry
Levin, M., (2006)
Birth Defects Research (Part C), 78: 191-223
2005
Asymmetric expression of Syndecan-2 in early chick embryogenesis
Fukumoto, T., and Levin, M., (2005)
Syndecan-2 , 5(4): 525-528
Serotonin signaling is a very early step in patterning of the left-right axis in chick and frog embryos
Fukumoto, T., Kema, I. P., and Levin, M., (2005)
Current Biology, 15(9): 794-803
Eye regeneration assay reveals an invariant functional left-right asymmetry in the early bilaterian, Dugesia japonica
Nogi, T., Yuan, Y. E., Sorocco, D., Perez-Tomas, R., and Levin, M., (2005)
Laterality, 10(3): 193-205
Localization and loss-of-function implicates ciliary proteins in early, cytoplasmic roles in left-right asymmetry
Qiu, D., Cheng, S.M., Wozniak, L., McSweeney, M., Perrone, E., and Levin, M., (2005)
Developmental Dynamics, 234(1): 176-189
Xenopus TRPN1 (NOMPC) localizes to microtubule-based cilia in epithelial cells, including inner-ear hair cells
Shin, J-B., Adams, D., Paukert, M., Siba, M., Sidi, S., Levin, M., Gillespie, P. G., and Grunder, S., (2005)
Proceedings of the National Academy of Sciences of the United States, 102(35): 12572-12577
BMP-3 is a novel inhibitor of both activin and BMP-4 signaling in Xenopus embryos
Gamer, L. W., Nove, J., Levin, M., and Rosen, V., (2005)
Developmental Biology, 285(1): 156-168
Characterization of innexin gene expression and functional roles of gap-junctional communication in planarian regeneration
Nogi, T., and Levin, M., (2005)
Developmental Biology, 287: 314-335
Serotonin transporter function is an early step in left-right patterning in chick and frog embryos
Fukumoto, T., Blakely, R., and Levin, M., (2005)
Developmental Neuroscience, 27(6): 349-363
Left-right asymmetry in embryonic development: a comprehensive review
Levin, M., (2005)
Mechanisms of Development, 122(1): 3-25 [cover]
2004
A novel immunohistochemical method for evaluation of antibody specificity and detection of labile targets in biological tissue
Levin, M., (2004)
Journal of Biophysical and Biochemical Methods, 58(1): 85-96
The embryonic origins of left-right asymmetry
Levin, M., (2004)
Critical Reviews in Oral Biology and Medicine, 15(4): 197-206
Early Patterning of the Left/Right Axis
Adams, D. S., and Levin, M. (2004). .
in C. D. Stern (Ed.), Gastrulation: from cells to embryo, Cold Spring Harbor, New York, pp. 403-417
2003
Fusicoccin signaling reveals 14-3-3 protein function as a novel step in left-right patterning during amphibian embryogenesis
Bunney, T. D., De Boer, A. H., and Levin, M., (2003)
Development, 130(20): 4847-4858
Left-Right Asymmetry in Amphibian Embryogenesis
Levin, Michael, (2003), ,
in Developmental Biology, Vol. 6 of Biology of the Amphibia, edited by Harold Heatwole and Brenda Brizuela
Bioelectromagnetics in morphogenesis
Levin, M., (2003)
Bioelectromagnetics, 24(5): 295-315
Motor protein control of ion flux is an early step in embryonic left-right asymmetry
Levin, M., (2003)
BioEssays, 25(10): 1002-1010
2002
Asymmetries in H+/K+-ATPase and cell membrane potentials comprise a very early step in left-right patterning
Levin, M., Thorlin, T., Robinson, K., Nogi, T., and Mercola, M., (2002)
Cell, 111(1): 77-89
Early embryonic expression of ion channels and pumps in chick and Xenopus development
Rutenberg, J., Cheng, S. M., and Levin, M., (2002)
Developmental Dynamics, 225(4): 469-484
Katp channel activity is required for hatching in Xenopus
Cheng, S. M., Chen, I., and Levin, M., (2002)
Developmental Dynamics, 225(4): 588-591
Isolation and community: A review of the role of gap-junctional communication in embryonic patterning
Levin, Michael, (2002)
Journal of Membrane Biology, 185(3): 177-192
2001
Left-Right asymmetry determination in vertebrates
Mercola, M., and Levin, M., (2001)
Annual Review of Cell and Developmental Biology, 17: 779-805
Asymmetry of Body and Brain: Embryological and Twin Studies
Levin, M., (2001)
in N. Smelser and P. Baltes (Eds.), International Encyclopedia of the Social and Behavioral Sciences, Elsevier, Oxford, UK, pp. 853-859
2000
Expression of Connexin30 in Xenopus embryos and its involvement in hatching gland function
Levin, M., and Mercola, M., (2000)
Developmental Dynamics, 219(1): 96-101
1999
Matrix-based GA representations in a model of evolving animal communication
Levin, M., (1999)
in L. Chambers (Ed.), The Practical Handbook of Genetic Algorithms: Complex Coding Systems, Vol. 3, ch.5, pp. 103-117, CRC Press: Boca Raton, FL
Twinning and embryonic left-right asymmetry
Levin, Michael, (1999)
Laterality, 4(3): 197-208
Cerberus regulates left-right asymmetry of the embryonic head and heart
Zhu, L., Marvin, M. J., Gardiner, A., Lassar, A. B., Mercola, M., Stern, C. D., and Levin, M., (1999)
Current Biology, 9(17): 931-938
Gap Junction-Mediated Transfer of Left-Right Patterning Signals in the Early Chick Blastoderm is Upstream of Shh Asymmetry in the Node
Levin, M., and Mercola, M., (1999)
Development, 126(21): 4703-4714
Left-right asymmetry in animal embryogenesis
Levin, M., (1999)
in G. Palyi, C. Zucchi, and L. Caglioti (Eds.), Advances in Biochirality, ch. 12, pp. 137-152, Elsevier Science Ltd: Oxford, UK
Endogenous electromagnetic fields and radiations in regeneration, development, and neoplasm
Levin, M., (1999)
Proceedings of the First World Congress on the Effects of Electricity and Magnetism in the Natural World, Madeira, Portugal
1998
The roles of activin and follistatin signaling in chick gastrulation
Levin, M., (1998)
International Journal of Developmental Biology, 42(4): 553-559
Gap junctions are involved in the early generation of left right asymmetry
Levin, M., and Mercola, M., (1998)
Developmental Biology, 203(1): 90-105
Evolutionary conservation of mechanisms upstream of asymmetric nodal expression: Reconciling chick and Xenopus
Levin, M., and Mercola, M., (1998)
Developmental Genetics, 23(3): 185-193
Left-Right asymmetry and the chick embryo
Levin, M., (1998)
Seminars in Cell & Developmental Biology, 9(1): 67-76
The compulsion of chirality: toward an understanding of left-right asymmetry
Levin, M., and Mercola, M., (1998)
Genes & Development, 12(6): 763-769
1997
Applied DC magnetic fields cause alterations in the time of cell divisions and developmental abnormalities in early sea urchin embryos
Levin, M., and Ernst, S. G., (1997)
Bioelectromagnetics, 18(3): 255-263
Two molecular models of initial left-right asymmetry generation
Levin, M., and Nascone, N., (1997)
Medical Hypotheses, 49(5): 429-435
Left-right asymmetry in vertebrate embryogenesis
Levin, M., (1997)
BioEssays, 19(4): 287-296 [cover]
1996
Laterality defects in conjoined twins
Levin, M., Roberts, D. J., Holmes, L. B., and Tabin, C., (1996)
Nature, 384(6607): 321
1995
Applied AC and DC Magnetic Fields Cause Alterations in the Mitotic Cycle of Early Sea Urchin Embryos
Levin, M., and Ernst, S. G., (1995)
Bioelectromagnetics, 16(4): 231-240
A molecular pathway determining left-right asymmetry in chick embryogenesis
Levin, M., Johnson, R.L., Stern, C. D., Kuehn, M., and Tabin, C., (1995)
Cell, 82(5): 803-814 [cover]
Use of Genetic Algorithms to Solve Biomedical Problems
Levin, M., (1995)
M.D. Computing, 12(3): 193-198
The evolution of understanding: A genetic algorithm model of the evolution of animal communication
Levin, M., (1995)
BioSystems, 36(3): 167-178
Locating putative protein signal sequences
Levin, M., (1995), ,
in L. Chambers (Ed.), The Practical Handbook of Genetic Algorithms: New Frontiers, Vol. 2, ch. 2, pp. 53-66, CRC Press: Boca Raton, FL
1994
A Julia set model of field-directed morphogenesis: developmental biology and artificial life
Levin, M., (1994)
Computer Applications in the Biosciences, 10(2): 85-103
Discontinuous and alternate q-system fractals
Levin, M., (1994)
Computers and Graphics, 18(6): 873-884
1993
Current and potential applications of bioelectromagnetics in medicine
Levin, M., (1993)
ISSEEM Journal, 4(1): 77-87
Abstracts
Transmembrane voltage gradient in GlyR-expressing niche cells controls behavior of neural crest derivatives in vivo
Blackiston, Douglas; Adams, Dany; Lemire, Joan; Levin, Michael, (2010)
Developmental Biology, 344(1): 526
Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration
Oviedo, N. J.; Morokuma, J.; Walentek, P.; Kema, I. P.; Gu, M. B.; Ahn, J.M.; Hwang, J. S.; Gojobori, T.; Levin, M., (2010)
Developmental Biology, 344(1): 522
NaV-mediated sodium transport is required for vertebrate appendage regeneration
Tseng, A. S., Beane, W. S., Lemire, J. M., Masi, A., Levin, M. (2010)
Developmental Biology, 344(1): 519
H,K-ATPase-mediated ion transport regulates anterior patterning in regenerating planaria
Beane W. S., Morokuma J., Levin M., (2010)
Developmental Biology, 344(1): 522
The Par6 complex is required for both early and late orientation of the left-right axis in Xenopus
Vandenberg, L., and Levin, M., (1010)
Developmental Biology, 344(1): 426-427
H,K-ATPase-mediated ion transport regulates anterior patterning in regenerating planaria
Beane W. S., Oviedo N.J., Adams D. S., Levin M. (2009)
Mechanisms of Development, 126 (Sup. 1): S294-S295
Role of KvLQT-1/minK K+ channel in early embryonic patterning
Morokuma, J., and Levin, M., (2006)
Developmental Biology, 295(1): 451-
A leftward fluid flow precedes nodal induction in Xenopus
Blum, M., Schweickert, A., Beyer, T., Weber, T., Andre, P., Fischer, A., Viebahn, C., M. Levin, (2006)
Developmental Biology, 295(1): 443
Xenopus tadpole tail regeneration requires the activity of the proton pump V- ATPase, and proton pumping is sufficient to partially rescue the loss of function phenotype
Adams, D. S., Masi, A., Levin, M., (2006)
Developmental Biology, 295(1): 355-356
Bioelectrical controls of morphogenesis
Levin, M., Adams, D. S., Aw, S., Morokuma, J., Oviedo, N. J., (2006)
Developmental Biology, 295(1):331-332
The Role of KATP Channels in Development of Left-Right Asymmetry in Xenopus
Chen, I., and Levin, M., (2004)
Journal of Dental Research., 83: A1340.
Electrical Controls of Regeneration in Planaria
Nogi, T. and Levin, M., (2003)
Developmental Biology, 259: 586
Electric Embryos: Endogenous Ion Fluxes and Voltage Gradients in Left—Right Asymmetry
Levin, M., (2003)
Developmental Biology, 259: 482
Elements of Left—Right Patterning: Gap Junctions, pH, and Membrane Voltage
Adams, D., and Levin, M., (2003)
Developmental Biology, 259: 482
Serotonin Is a Novel Very Early Signaling Mechanism in Left—Right Asymmetry
Fukumoto, T., and Levin, M., (2003)
Developmental Biology, 259: 490
Gap junction-mediated transfer of left-right patterning signals
Levin, M., and Mercola, M. (1999)
Molecular Biology of the Cell, 39: 1
From left-right asymmetric gene expression to its morphological manifestations
Pagan S. M., Levin M., Tabin C., (1997)
Journal of Morphology, 232(3): 306
DC and AC magnetic field effects on early sea-urchin development
Levin, M., Gonzalez, J. L., and Ernst, Susan G., (1991)
Biological Bulletin, 181: 511-