Publications
Browse peer-reviewed publications by topic
All Peer-reviewed Publications
2024
Classical sorting algorithms as a model of morphogenesis: Self-sorting arrays reveal unexpected competencies in a minimal model of basal intelligence
Zhang, T., Goldstein, A., Levin M. (2024)
Adaptive Behavior 2024, doi: 10.1177/10597123241269740
Oscillatory phenomena in electrophysiological networks: The coupling between cell bioelectricity and transcription
Cervera, J., Manzanares, J. A., Levin, M., Mafe, S. (2024)
Computers in Biology and Medicine 2024, 180 doi: 10.1016/j.compbiomed.2024.108964
Stress sharing as cognitive glue for collective intelligences: A computational model of stress as a coordinator for morphogenesis
Shreesha, L., Levin, M. (2024)
Biochemical and Biophysical Research Communications 2024, 731 doi: 10.1016/j.bbrc.2024.150396
Toward a nomenclature consensus for diverse intelligent systems: Call for collaboration
Kagan, B. J., Mahlis, M., Bhat, A., Bongard, J., Cole, V. M., Corlett, P., Gyngell, C., Hartung, T., Jupp, B., Levin, M., Lysaght, T., Opie, N., Razi, A., Smirnova, L., Tennant, Ian, Wade, P. T., Wang, G. (2024)
The Innovation 2024, 5(9) doi:10.1016/j.xinn.2024.100658
Evolutionary Implications of Self-Assembling Cybernetic Materials with Collective Problem-Solving Intelligence at Multiple Scales
Hartl, B., Risi, S., Levin, M. (2024)
Entropy 2024, 26(7), 532 doi:10.3390/e26070532
Self-Amputating and Interfusing Machines
Yang, B., Nasab, A. M., Woodman, S.J., Thomas, E., Tilton, L.G., Levin, M., Kramer-Bottiglio, R. (2024)
Advanced Materials 2024, 2400241, doi:10.1002/adma.202400241
Self-Improvising Memory: A Perspective on Memories as Agential, Dynamically Reinterpreting Cognitive Glue
Levin, M. (2024)
Entropy, 26(6), 481; doi: 10.3390/e26060481
A pro-reparative bioelectronic device for controlled delivery of ions and biomolecules
Asefifeyzabadi, N., Nguyen, T., Li, H., Zhu, K., Yang , H., Baniya, P., PhD, Lopez, A. M., Gallegos, A., Hsieh, H. Dechiraju, H., Hernandez, C., Schorger, K., Recendez, C., Tebyani, M., Selberg, J., Luo, L., Muzzy, E., Hsieh, C., Barbee, A., Orozco, J., Alhamo, M.A., Levin, M., Aslankoohi, E., Gomez, M., Zhao, M., Teodorescu, M., Isseroff, R. R., Rolandi, M. (2024)
Wound Rep Reg, 1-11 (2024) doi:10.1111/wrr.13191
Collective intelligence: A unifying concept for integrating biology across scales and substrates
McMillen, P., Levin, M. (2024)
Communications Biology, 2024, 7, 378 doi:10.1038/s42003-024-06037-4
Unraveling the Enigma of Organismal Death: Insights, Implications, and Unexplored Frontiers
Noble, P. A., Pozhitkov, A., Singh, K., Woods, E., Liu, C., Levin, M., Javan, G., Wan, J., Abouhashem, A. S., Mathew-Steiner, S. S., Sen, C. K. (2024)
ACS Physiology, 2024 doi:10.1152/physiol.00004.2024
Snakes and ladders in the evolution of language
Field, C., and Levin, M. (2024)
Physics of Life Reviews, 2024 doi:10.1016/j.plrev.2024.04.007
Aging as a loss of morphostatic information: a developmental bioelectricity perspective
Pio-Lopez, L., Levin, M. (2024)
Ageing Research Reviews, 2024, 97:102310, doi:10.1016/j.arr.2024.102310
Programmable delivery of fluoxetine via wearable bioelectronics for wound healing in vivo
Li, H., Yang, H.-Y., Asefifeyzabadi, N., Baniya, P., Medina Lopez, A., Gallegos, A., Zhu, K., Hsieh, H.-C., Nguyen, T., Hernandez, C., Zlobina, K., Recendez, C., Tebyani, M., Carrión, H., Selberg, J., Luo, L., Alhamo, M. A., Soulika, A. M., Levin, M., Norouzi, N., Gomez, M., Zhao, M., Teodorescu, M., Isseroff, R. R., Rolandi, M. (2024)
Advanced Materials Technology, 9(7):2301115
Electroceuticals: emerging applications beyond the nervous system and excitable tissues
Balasubramanian, S., Weston, D., Levin, M., Davidian, D. C. C. (2024)
Trends Pharmacol Sci, 2109 doi.org/10.1016/j.tips.2024.03.001
Charging Ahead: Examining the future therapeutic potential of electroceuticals
Balasubramanian, S., Weston, D., Levin, M., Davidian, D. C. C. (2024)
Advanced Therapeutics, in press
Principled Limitations on Self-Representation for Generic Physical Systems
Fields, C., Glazebrook, J. F., and Levin, M. (2024)
Entropy, 26(3): 194
AI-driven Automated Discovery Tools Reveal Diverse Behavioral Competencies of Biological Networks
Etcheverry, M., Moulin-Frier, C., Oudeyer, P.-Y., and Levin, M. (2024)
eLife, 13: RP92683
Embryos assist morphogenesis of others through calcium and ATP signaling mechanisms in collective teratogen resistance
Tung, A., Sperry, M., Clawson, W., Pavuluri, A., Bulatao, S., Yue, M., Flores, R. M., Pai, V. McMillen, P., Kuchling, F., and Levin, M. (2024)
Nature Communications, 15(1): 535
Machine Learning for Hypothesis Generation in Biology and Medicine: Exploring the latent space of neuroscience and developmental bioelectricity
O’Brien, T., Stremmel, J., Pio-Lopez, L., McMillen, P., Rasmussen-Ivey, C., and Levin, M. (2024)
Digital Discovery, 3(2): 249-263
Optical Estimation of Bioelectric Patterns in Living Embryos
McMillen, P., and Levin, M. (2024)
in M. Bizzarri (Ed.), Systems Biology: Methods in Molecular Biology, 2745: 91-102, doi:10.1007/978-1-0716-3577-3_6
From reinforcement learning to agency: Frameworks for understanding basal cognition
Seifert, G., Sealander, A., Marzen, S., and Levin, M. (2024)
BioSystems, 235(1): 105107
2023
Nested Selves: Self-Organization and Shared Markov Blankets in Prenatal Development in Humans
Ciaunica, A., Levin, M., Rosas, F. E., and Friston, K. (2023)
Topics in Cognitive Science, in press, doi:10.1111/tops.12717
Motile Living Biobots Self-Construct from Adult Human Somatic Progenitor Seed Cells
Gumuskaya, G., Srivastava, P., Cooper, B. G., Lesser, H., Semegran, B., Garnier, S., and Levin, M. (2023)
Advanced Science, doi:10.1002/advs.202303575
Information integration during bioelectric regulation of morphogenesis of the embryonic frog brain
Manicka, S., Pai, V. P, and Levin, M. (2023)
iScience, 26(12): 108398
The Multiple Realizability of Sentience in Living Systems and Beyond
Rouleau, N., and Levin, M. (2023)
eNeuro, 10(11), doi:10.1523/eneuro.0375-23.2023
Long Range Communication via Gap Junctions and Stress in Planarian Morphogenesis: A Computational Study
Blattner, M., and Levin, M. (2023)
Bioelectricity, 5(3): 196-209
Cancer’s unique bioelectric properties: from cells to body-wide networks, Comment on: “The distinguishing electrical properties of cancer cells” by Elisabetta Di Gregorio, Simone Israel, Michael Staelens, Gabriella Tankel, Karthik Shankar, and Jack A. Tuszynski
Mathews, J., and Levin, M. (2023)
Physics of Life Reviews, 47: 113-115
Optimization of Oligomer Stamping Technique for Normally Closed Elastomeric Valves on Glass Substrate
Dungan, J., Mathews, J., Levin, M., and Koomson, V. (2023)
Micromachines, 14(9): 1659
Collective Intelligence of Morphogenesis as a Teleonomic Process
Levin, M. (2023)
in Corning, P. A., Kauffman, S. A., Noble, D., Shapiro, J. A., Vane-Wright, R. I. Pross, A. (Eds.), Evolution "On Purpose": Teleonomy in Living Systems, The MIT Press: Cambridge, MA, 175-197
Endless forms most beautiful 2.0: teleonomy and the bioengineering of chimaeric and synthetic organisms
Clawson, W. P., and Levin, M. (2023)
Biological Journal of the Linnean Society, 139(4): 457-486 [cover]
Closing the Loop on Morphogenesis: A Mathematical Model of Morphogenesis by Closed-Loop Reaction-Diffusion
Grodstein, J., McMillen, P., and Levin, M. (2023)
Frontiers in Cell and Developmental Biology, 11: 1087650
Correcting instructive electric potential patterns in multicellular systems: External actions and endogenous processes
Cervera, J., Levin, M., and Mafé, S. (2023)
Biochimica et Biophysica Acta (BBA) - General Subjects, 1867(10): 130440
Searching in the Dark: Evolving Biobot Swarm Compositions to Efficiently Explore Obstructed Environments
Welch, P., Grasso, C., Gumuskaya, G., Levin, M., and Bongard, J. (2023)
Proceedings of ALIFE 2023: Ghost in the Machine, article 70, doi:10.1162/isal_a_00683
Future Medicine: from molecular pathways to the collective intelligence of the body
Lagasse, E., and Levin, M. (2023)
Trends in Molecular Medicine, 29(9): 687-710 [cover]
Multiple ways to implement and infer sentience: Commentary on Segundo-Ortiz & Calvo on Plant Sentience
Rouleau, N., and Levin, M. (2023)
Animal Sentience, 8(33): 30
The Yin and Yang of Breast Cancer: Ion Channels as Determinants of Left-Right Functional Differences
Masuelli, S., Real, S., McMillen, P., Oudin, M., Levin, M., and Roqué, M. (2023)
International Journal of Molecular Sciences, 24(13): 11121
Towards an Ethics of Autopoietic Technology: Stress, Care, and Intelligence
Witkowski, O., Doctor, T., Solomonova, E., Duane, B., and Levin, M. (2023)
Biosystems, 231: 104964
Bioelectricidad en agregados multicelulares de células no excitables: modelos biofísicos
Cervera, J., Levin, M., and Mafé, S. (2023)
Revista Española de Física, 37(2), 24-29
The Brain is not Mental! Coupling Neuronal and Immune Cellular Processing in Human Organisms
Ciaunica, A., Shmeleva, E. V., and Levin, M. (2023)
Frontiers in Integrative Neuroscience, 17: 1057622
Regulative development as a model for origin of life and artificial life studies
Fields, C., and Levin, M. (2023)
Biosystems, 229: 104927
The collective intelligence of evolution and development
Watson, R., and Levin, M. (2023)
Collective Intelligence, 2(2), doi:10.1177/26339137231168355
Bioelectric Networks: the cognitive glue enabling evolutionary scaling from physiology to mind
Levin, M. (2023)
Animal Cognition, doi:10.1007/s10071-023-01780-3
Control flow in active inference systems Part II: Tensor networks as general models of control flow
Fields, C., Fabrocini, F., Friston, K., Glazebrook, J. F., Hazan, H., Levin, M., and Marcianò, A. (2023)
IEEE Transactions on Molecular, Biological, and Multi-Scale Communications, doi:10.1109/TMBMC.2023.3272158
Control flow in active inference systems Part I: Classical and quantum formulations of active inference
Fields, C., Fabrocini, F., Friston, K., Glazebrook, J. F., Hazan, H., Levin, M., and Marcianò, A. (2023)
IEEE Transactions on Molecular, Biological, and Multi-Scale Communications, doi:10.1109/TMBMC.2023.3272150
Darwin’s agential materials: evolutionary implications of multiscale competency in developmental biology
Levin, M. (2023)
Cellular and Molecular Life Sciences, 80: 142
Morphoceuticals: Perspectives for discovery of drugs targeting anatomical control mechanisms in regenerative medicine, cancer and aging
Pio-Lopez, L., and Levin, M. (2023)
Drug Discovery Today, 28(6): 103585
Cellular Signaling Pathways as Plastic, Proto-cognitive Systems: Implications for Biomedicine
Mathews, J., Chang, J., Devlin, L., and Levin, M. (2023)
Patterns, 4: 100737
Biological Robots: Perspectives on an Emerging Interdisciplinary Field
Blackiston, D., Kriegman, S., Bongard, J., and Levin, M. (2023)
Soft Robotics, 10(4): 694-686
The scaling of goals via homeostasis: an evolutionary simulation, experiment and analysis
Pio-Lopez, L., Bischof, J., LaPalme, J. V., and Levin, M. (2023)
Interface Focus, 13(3): 20220072 [cover]
The nonlinearity of regulation in biological networks
Manicka, S., Johnson, K., Levin, M., and Murrugarra, D. (2023)
npj Systems Biology and Applications, 9(1): 10
There’s Plenty of Room Right Here: Biological Systems as Evolved, Overloaded, Multi-Scale Machines
Bongard, J., and Levin, M. (2023)
Biomimetics, 8(1): 110
Synthetic morphology with agential materials
Davies, J., and Levin, M. (2023)
Nature Reviews Bioengineering, 1(1): 46-59
Cellular Competency during Development Alters Evolutionary Dynamics in an Artificial Embryogeny Model
Shreesha, L., and Levin, M. (2023)
Entropy, 25(1): 131
Bioelectricity of non-excitable cells and multicellular pattern memories: Biophysical modeling
Cervera, J., Levin, M., and Mafe, S. (2023)
Physics Reports, 1004: 1-31
Learning in Transcriptional Network Models: Computational Discovery of Pathway-level Memory and Effective Interventions
Biswas, S., Clawson, W., and Levin, M. (2023)
International Journal of Molecular Sciences, 24(1): 285
Transplantation of fragments from different planaria: a bioelectrical model for head regeneration
Cervera, J., Manzanares, J. A., Levin, M., and Mafe, S. (2023)
Journal of Theoretical Biology, 558: 111356
2022
Exploring the Behavior of Bioelectric Circuits Using Evolution Heuristic Search
Hazan, H., and Levin, M. (2022)
Bioelectricity, 4(4): 207-227
On-chip on-demand delivery of K+ for in vitro bioelectronics
Dechiraju, H., Selberg, J., Jia, M., Pansodtee, P., Li, H., Hsieh, H-C., Hernandez, C., Asefifeyzabadi, N., Nguyen, T., Baniya, P., Marquez, G., Rasmussen-Ivey, C., Bradley, C., Teodorescu, M., Gomez, M., Levin, M., and Rolandi, M. (2022)
AIP Advances, 12(12): 125205
Active Inference, Morphogenesis, and Computational Psychiatry
Pio-Lopez, L., Kuchling, F., Tung, A., Pezzulo, G., and Levin, M. (2022)
Frontiers in Computational Neuroscience, 16: 988977
The Free Energy Principle induces neuromorphic development
Fields, C., Friston, K., Glazebrook, J. F., Levin, M., and Marcianò, A. (2022)
Neuromorphic Computing and Engineering, 2: 042002
Information Theory as an experimental tool for integrating disparate biophysical signaling modules
McMillen, P., Walker, S. I., and Levin, M. (2022)
International Journal of Molecular Sciences, 23(17): 9580
Adversarial Takeover of Neural Cellular Automata
Cavuoti, L., Sacco, F., Randazzo, E., and Levin, M. (2022)
Proceedings of the 2022 Conference on Artificial Life (ALIFE 2022), pp. 256-263
Competition for Finite Resources as Coordination Mechanism for Morphogenesis: an evolutionary algorithm study of digital embryogeny
Smiley, P., and Levin, M. (2022)
BioSystems, 221: 104672
Generalizing frameworks for sentience beyond natural species
Levin, M. (2022)
Animal Sentience, 7(32): 15
Screening Biophysical Sensors and Neurite Outgrowth Actuators in Human Induced-Pluripotent-Stem-Cell-Derived Neurons
Pai, V. P., Cooper, B. G., and Levin, M. (2022)
Cells, 11(16): 2470
Enhancers of Host Immune Tolerance to Bacterial Infection Discovered Using Linked Computational and Experimental Approaches
Sperry, M. M., Novak, R., Keshari, V., Dinis, A. L. M., Cartwright, M. J., Camacho, D. M., Paré, J. F., Super, M., Levin, M., & Ingber, D. E. (2022)
Advanced Science, 9(26): 2200222 [cover]
HCN2 Channel-induced Rescue of Brain, Eye, Heart, and Gut Teratogenesis Caused by Nicotine, Ethanol, and Aberrant Notch Signaling
Pai, V. P., and Levin, M. (2022)
Wound Repair and Regeneration, 30(6): 6810706
Biology, Buddhism, and AI: Care as the Driver of Intelligence
Doctor, T., Witkowski, O., Solomonova, E., Duane, B., and Levin, M. (2022)
Entropy, 24(5): e24050710
Competency in Navigating Arbitrary Spaces as an Invariant for Analyzing Cognition in Diverse Embodiments
Fields, C., and Levin, M. (2022)
Entropy, 24(6): 819
Neurons as hierarchies of quantum reference frames
Fields, C., Glazebrook, J. F., and Levin, M. (2022)
Biosystems, 219: 104714
A free energy principle for generic quantum systems
Fields, C., Friston, K., Glazebrook, J. F., and Levin, M. (2022)
Progress in Biophysics and Molecular Biology, 173: 36-59
Metacognition as a Consequence of Competing Evolutionary Time Scales
Kuchling, F., Fields, C., and Levin, M. (2022)
Entropy, 24(5): 601
Design for an Individual: Connectionist approaches to the evolutionary transitions in individuality
Watson, R. A., Levin, M., and Buckley, C. L. (2022)
Frontiers in Ecology and Evolution, 10: 823588
Technological Approach to Mind Everywhere: an experimentally-grounded framework for understanding diverse bodies and minds
Levin, M. (2022)
Frontiers in Systems Neuroscience, 16: 768201
Biological underpinnings for lifelong learning machines
Kudithipudi, D., Aguilar-Simon, M., Babb, J., Bazhenov, M., Blackiston, D., Bongard, J., Brna, A. P., Raja, S. C., Cheney, N., Clune, J., Daram, A., Fusi, S., Helfer, P., Kay, L., Ketz, N., Kira, Z., Kolouri, S., Krichmar, J. L., Kriegman, S., Levin, M., Madireddy, S., Manicka, S., Marjaninejad, A., McNaughton, B., Miikkulainen, R., Navratilova, Z., Pandit, T., Parker, A., Pilly, P. K., Risi, S., Sejnowski, T. J., Soltoggio, A., Soures, N., Tolias, A. S., Urbina-Meléndez, D., Valero-Cuevas, F. J., van de Ven, G. M., Vogelstein, J. T., Wang, F., Weiss, R., Yanguas-Gil, A., Zou, X., and Siegelmann, H. (2022)
Nature Machine Intelligence, 4(3): 196-210
Studying Protista WBR and Repair Using Physarum polycephalum
Sperry, M. M., Murugan, N. J., and Levin, M. (2022)
in S. Blanchoud and B. Galliot (Eds.), Whole-Body Regeneration: Methods in Molecular Biology, 2450: 51-67
Ion Channel Drugs Suppress Cancer Phenotype in NG108-15 and U87 Cells: Toward Novel Electroceuticals for Glioblastoma
Mathews, J., Kuchling, F., Baez-Nieto, D., Diberardinis, M., Pan, J. Q., and Levin, M. (2022)
Cancers, 14(6): 1499
Modular cognition
Levin, M., and Yuste, R. (2022)
Aeon Essays [cover]
Multi-scale Chimerism: an experimental window on the algorithms of anatomical control
Nanos, V., and Levin, M. (2022)
Cells and Development, 169: 203764 [cover]
A Computational Approach to Explaining Bioelectrically-induced Persistent, Stochastic Changes of Axial Polarity in Planarian Regeneration
Grodstein, J., and Levin, M. (2022)
Bioelectricity, 4(1): 18-30
Impact of Membrane Voltage on Formation and Stability of Human Renal Tubules in Vitro
Adelfio, M., Bonzanni, M., Levin, M., and Kaplan, D. L. (2022)
ACS Biomaterials Science & Engineering, 8(3): 1239-1246
When left does not seem right: epigenetic and bioelectric differences between left- and right-sided breast cancer
Masuelli, S., Sebastian, R., Campoy, E., Branham, M. T., Marzese, D. M., Matthew, S., DeBlas, G., Rodolfo, A., Levin, M., and Roque, M. (2022)
Molecular Medicine, 28(1): 15
Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adult Xenopus laevis
Murugan, N. J., Vigran, H. J., Miller, K., Golding, A., Pham, Q. L., Sperry, M., Rasmussen-Ivey, C., Kane, A. W., Kaplan, D. L., and Levin, M. (2022)
Science Advances, 8(4): abj2164 [cover]
Minimal developmental computation: a causal network approach to understand morphogenetic pattern formation
Manicka, S., and Levin, M. (2022)
Entropy, 24: 107
Potassium channel-driven bioelectric signalling regulates metastasis in triple-negative breast cancer
Payne, S. L., Ram, P., Srinivasan, D. H., Le, T. T., Levin, M., and Oudin, M. J. (2022)
EBioMedicine, 75: 103767
2021
Morphology changes induced by intercellular gap junction blocking: a reaction-diffusion mechanism
Cervera, J., Levin, M., and Mafe, S. (2021)
BioSystems, 209: 104511
Evolution and emergence: higher order information structure in protein interactomes across the tree of life
Klein, B., Hoel, E., Swain, A., Griebenow, R., and Levin, M. (2021)
Integrative Biology, 13(12): 283-294 [cover]
New Clues about the Origins of Biological Intelligence
Yuste, R., and Levin, M. (2021)
Scientific American, December 2021
Kinematic self-replication in reconfigurable organisms
Kriegman, S., Blackiston, D., Levin, M., and Bongard, J. (2021)
Proceedings of the National Academy of Science, 118(49): e2112672118
Behaviorist Approaches to Investigating Memory and Learning: A Primer for Synthetic Biology and Bioengineering
Abramson, C., and Levin, M. (2021)
Communicative & Integrative Biology, 14(1): 230-247
Cell Systems Bioelectricity: How Different Intercellular Gap Junctions Could Regionalize a Multicellular Aggregate
Riol, A., Cervera, J., Levin, M., and Mafe, S. (2021)
Cancers, 13(21): 5300
Metabolic limits on classical information processing by biological cells
Fields, C., and Levin, M. (2021)
BioSystems, 209: 104513
Beyond Neurons: Long Distance Communication in Development and Cancer
McMillen, P., Oudin, M. J, Levin, M., and Payne, S. L. (2021)
Frontiers in Cell and Developmental Biology, 9: 739024
Stability and robustness properties of bioelectric networks: A computational approach
Grodstein, J., and Levin, M. (2021)
Biophysics Review, 2(3): 031305
Minimal physicalism as a scale-free substrate for cognition and consciousness
Fields, C., Glazebrook, J. F., and Levin, M. (2021)
Neuroscience of Consciousness, 7(2): niab013
Mechanosensation Mediates Long-Range Spatial Decision-Making in an Aneural Organism
Murugan, N., Kaltman, D., Jin, H., Chien, M., Flores, R., Nguyen, C., Tuzoff, D., Minabutdinov, A., Kane, A., Novak, R., Ingber, D., and Levin, M. (2021)
Advanced Materials, 33(34): 2008161 [cover]
Life, death, and self: Fundamental questions of primitive cognition viewed through the lens of body plasticity and synthetic organisms
Levin, M. (2021)
Biochemical and Biophysical Research Communications, 564: 114-133 [cover]
Scale invariant robot behavior with fractals
Kriegman, S., Nasab, A-M., Blackiston, D., Steele, H., Levin, M., Kramer-Bottiglio, R., and Bongard, R. (2021)
Robotics: Science and Systems (RSS), doi:10.15607/RSS.2021.XVII.059
Unmixing octopus camouflage by multispectral mapping of Octopus bimaculoides' chromatic elements
Guidetti, G., Levy, G., Matzeu, G., Finkelstein, J. M., Levin, M., and Omenetto, F. G. (2021)
Nanophotonics, 10(9): 2441-2450
Synthetic living machines: A new window on life
Ebrahimkhani, M., and Levin, M. (2021)
iScience, 24(5): 102505
Adversarial Reprogramming of Neural Cellular Automata: a robustness investigation
Randazzo, E., Mordvintsev, A., Niklasson, E., and Levin, M. (2021)
Distill, 6(5), doi:10.23915/distill.00027.004
Bioelectrical approaches to cancer as a problem of the scaling of the cellular self
Levin, M. (2021)
Progress in Biophysics and Molecular Biology, 165: 102-113
Learning and synaptic plasticity in 3D bioengineered neural tissues
Rouleau, N., Cairns, D. M., Rusk, W., Levin, M., and Kaplan, D. (2021)
Neuroscience Letters, 750: 135799
Bioelectric Signaling: Reprogrammable Circuits Underlying Embryogenesis, Regeneration, and Cancer
Levin, M. (2021)
Cell, 184(8): 1971-1989
Bistability of Somatic Pattern Memories: Stochastic Outcomes in Bioelectric Circuits Underlying Regeneration
Pezzulo, G., Lapalme, J., Durant, F., and Levin, M. (2021)
Philosophical Proceedings of the Royal Society B, 376(1821): 20190765
Uncovering cognitive similarities and differences, conservation and innovation
Levin, M., Keijzer, F., Lyon, P., and Arend, D. (2021)
Philosophical Transactions of the Royal Society B, 376 (1821): 20200458 [cover]
Gene Regulatory Networks Exhibit Several Kinds of Memory: Quantification of Memory in Biological and Random Transcriptional Networks
Biswas, S., Manicka, S., Hoel, E., and Levin, M. (2021)
iScience, 24(3): 102131
A cellular platform for the development of synthetic living machines
Blackiston, D., Lederer, E., Kriegman, S., Garnier, S., Bongard, J., and Levin, M. (2021)
Science Robotics, 6(52): eabf1571
Living things are not (20th Century) machines: updating mechanism metaphors in light of the modern science of machine behavior
Bongard, J., and Levin, M. (2021)
Frontiers in Ecology and Evolution, 9: 650726
Unlimited plasticity of embodied, cognitive subjects: a new playground for the UAL framework
Levin, M. (2021)
Biology and Philosophy, 36(2): 17
Self-organising Textures: Neural Cellular Automata Model of Pattern Formation
Niklasson, E., Mordvintsev, A., Randazzo, E., and Levin, M. (2021)
Distill, 6(2), doi:10.23915/distill.00027.003
Epigenetic control of myeloid cells behavior by Histone Deacetylase Activity (HDAC) during tissue and organ regeneration in Xenopus laevis
Pentagna, N., Pinheiro da Costa, T., Soares Dos Santos, F., Martins de Almeida F., Martinez, A. M. B., Abreu, J. G., Levin, M., and Carneiro, K. (2021)
Developmental & Comparative Immunology, 114: 103840
Rewiring Endogenous Bioelectric Circuits in the Xenopus laevis Embryo Model
Nanos, V., and Levin, M. (2021)
in M. R. Ebrahimkhani and J. Hislop (Eds.), Programmed Morphogenesis: Methods in Molecular Biology, 2258: 93-103
Reframing cognition: getting down to biological basics
Lyon, P., Keijzer, F., Arendt, D., and Levin, M. (2021)
Philosophical Transactions of the Royal Society B, 376(1820): 20190750 [cover]
Shape changing robots: bioinspiration, simulation, and physical realization
Shah, D., Yang, B., Kriegman, S., Levin, M., Bongard, J., and Kramer-Bottiglio, R. (2021)
Advanced Materials, 33(19): 2002882
Inducing Vertebrate Limb Regeneration: A Review of Past Advances and Future Outlook
Davidian, D., and Levin, M. (2021)
Cold Spring Harbor Perspectives in Biology, doi:10.1101/cshperspect.a040782
A Meta-Analysis of Bioelectric Data in Cancer, Embryogenesis, and Regeneration
Srivastava, P., Kane, A., Harrison, C., and Levin, M. (2021)
Bioelectricity, 3(1): 42-67
A Comprehensive Conceptual and Computational Dynamics Framework for Autonomous Regeneration Systems
Minh-Thai, T. N., Samarasinghe, S., and Levin, M. (2021)
Artificial Life, 27(2): 80-104
2020
Why isn't sex optional? Stem-cell competition, loss of regenerative capacity, and cancer in metazoan evolution
Fields, C., and Levin, M. (2020)
Communicative & Integrative Biology, 13(1): 170-183
How Do Living Systems Create Meaning?
Fields, C., and Levin, M. (2020)
Philosophies, 5(4): 36-59
Community effects allow bioelectrical reprogramming of cell membrane potentials in multicellular aggregates: Model simulations
Cervera, J., Ramirez, P., Levin, M., and Mafe, S. (2020)
Physical Review E, 102(5): 052412
Nervous System and Tissue Polarity Dynamically Adapt to New Morphologies in Planaria
Bischof, J., Day, M., Miller, K., LaPalme, J., and Levin, M. (2020)
Developmental Biology, 467(1-2): 51-65 [cover]
Regulation of axial and head patterning during planarian regeneration by a commensal bacterium
Williams, K., Bischof, J., Lee, F., Miller, K., LaPalme, J., Wolfe, B., and Levin, M. (2020)
Mechanisms of Development, 163: 103614 [cover]
Bioelectronic Control of Chloride Ions and Concentration with Ag/AgCl Contacts
Jia, M., Dechiruji, H., Selberg J., Pansodtee P., Mathews, J., Wu, C., Levin, M., Teodorescu, M., and Rolandi, M. (2020)
APL Materials, 8(9): 091106
How Groups of Cells Cooperate to Build Organs and Organisms
Levin, M. (2020)
The Scientist, 34(9): 38-45 [cover]
Self-classifying MNIST Digits: Achieving Distributed Coordination with Neural Cellular Automata
Randazzo, E., Mordvintsev, A., Niklasson, E., Levin, M., and Greydanus, S. (2020)
Distill, 5(8), doi:10.23915/distill.00027.002
A 3D tissue model of traumatic brain injury with excitotoxicity that is inhibited by chronic exposure to gabapentinoids
Rouleau, N., Bonzanni, M., Erndt-Marino, J., Sievert, K., Ramirez, C., Rusk, W., Levin, M., and Kaplan, D. (2020)
Biomolecules, 10(8): 1196
Emergence of Informative Higher Scales in Biological Systems: a computational toolkit for optimal prediction and control
Hoel, E., and Levin, M.,(2020)
Communicative & Integrative Biology, 13(1): 108-118
Growing Neural Cellular Automata
Mordvintsev, A., Randazzo, E., Niklasson, E., and Levin, M. (2020)
Distill, 5(2), doi:10.23915/distill.00027.002
Applications and ethics of computer-designed organisms
Levin, M., Bongard, J., and Lunshof, J. E. (2020)
Nature Reviews Molecular Cell Biology, 21(11): 655–656
Scale-Free Biology: Integrating Evolutionary and Developmental Thinking
Fields, C., and Levin, M. (2020)
BioEssays, 42(8): 1900228
Competitive and Coordinative Interactions between Body Parts Produce Adaptive Developmental Outcomes
Gawne, R., McKenna, K., and Levin, M. (2020)
BioEssays, 42(8): 1900245 [cover]
von Willebrand factor D and EGF domains is an evolutionarily conserved and required feature of blastemas capable of multitissue appendage regeneration
Leigh, N. D., Sessa, S., Dragalzew, A. C., Payzin‐Dogru, D., Sousa, J. F., Aggouras, A. N., Johnson, K., Dunlap, G. S., Haas, B. J., Levin, M., Schneider, I., and Whited, J. L. (2020)
Evolution & Development, 22(4): 297-311 [cover]
Integrating Variational Approaches to Pattern Formation into a Deeper Physics: Reply to comments on "Morphogenesis as Bayesian Inference: A Variational Approach to Pattern Formation and Manipulation in Complex Biological Systems"
Kuchling, F., Friston, K., Georgiev, G., and Levin, M. (2020)
Physics of Life Reviews, 33: 125-128
Morphogenesis as Bayesian Inference: a Variational Approach to Pattern Formation and Control in Complex Biological Systems
Kuchling, F., Friston, K., Georgiev, G., and Levin, M. (2020)
Physics of Life Reviews, 33: 88-108
On the coupling of mechanics with bioelectricity and its role in morphogenesis
Leronni, A., Bardella, L., Dorfmann, L., Pietak, A., and Levin, M. (2020)
Journal of the Royal Society Interface, 17(167): 20200177
Richard Borgens, 1946-2019
Levin, M., and Rajnicek, A. M. (2020)
Bioelectricity, 2(2): 205
HCN2 Channel-induced Rescue of Brain Teratogenesis via local and long-range bioelectric repair
Pai, V., Cervera, J., Mafe, S., Willocq, V., Lederer, E., and Levin, M. (2020)
Frontiers in Cellular Neuroscience, 14: 136
Scalable sim-to-real transfer of soft robot designs
Kriegman, S., Nasab, A. M., Shah, D., Steele, H., Branin, G., Levin, M., Bongard, J., and Kramer-Bottiglio, R. (2020)
Proceedings of the 3rd IEEE International Conference on Soft Robotics (RoboSoft 2020), p. 359-366
Bioelectrical Coupling of Single-Cell States in Multicellular Systems
Cervera, J., Levin, M., and Mafe, S. (2020),
The Journal of Physical Chemistry Letters, 11(9): 3234-3241
Extra-genomic instructive influences in morphogenesis: A review of external signals that regulate growth and form
Tung, A., and Levin, M. (2020)
Developmental Biology, 461(1): 1-12 [cover]
Precise control of ion channel and gap junction expression is required for patterning of the regenerating axolotl limb
Sousounis, K., Erdogan, B., Levin, M., and Whited, J. (2020)
International Journal of Developmental Biology, 64(10-11-12): 485-494
Machine Learning-Driven Bioelectronics for Closed-Loop Control of Cells
Selberg, J., Jafari, M., Mathews, J., Jia, M., Pansodtee, P., Dechiraju, H., Wu, C., Cordero, S., Flora, A., Yonas, N., Jannetty, S., Diberardinis, M., Teodorescu, M., Levin, M., Gomez, M., and Rolandi, M. (2020)
Advanced Intelligent Systems, 2(12): 2000140 [cover]
Does evolution have a target morphology?
Fields, C., and Levin, M. (2020)
Organisms. Journal of Biological Sciences, 4(1): 57-76
Interferon-Gamma Stimulated Murine Macrophages in Vitro: Impact of Ionic Composition and Osmolarity and Therapeutic Implications
Erndt-Marino, J., Yeisley, D. J., Chen, H., Levin, M., Kaplan, D. L., and Hahn, M. S. (2020)
Bioelectricity, 2(1): 48-58
Opinion: Use the Pandemic to Expand the Lab to the Home
Levin, M. (2020)
The Scientist
Sertraline induces DNA damage and cellular toxicity in Drosophila that can be ameliorated by antioxidants
Jajoo, A., Donlon, C., Shnayder, S., Levin, M., and McVey, M. (2020)
Scientific Reports, 10: 4512
Revisiting Burr and Northrop's 'The Electro-Dynamic Theory of Life'
Levin, M. (2020)
Biological Theory, 15: 83-90
Eya2 promotes cell cycle progression by regulating DNA damage response during vertebrate limb regeneration
Sousounis, K., Bryant, D. M., Fernandez, J. M., Eddy, S. S., Tsai, S. L., Gundberg, G. C., Han, J., Courtemanche, K., Levin, M., and Whited, J. L. (2020)
eLIFE, 9: e51217
Does regeneration recapitulate phylogeny?
Fields, C., and Levin, M. (2020)
Communicative & Integrative Biology, 13(1): 27-38
An in vivo brain–bacteria interface: the developing brain as a key regulator of innate immunity
Herrera-Rincon, C., Paré, J-F., Martyniuk, C. J., Jannetty, S. K., Harrison C., Fischer, A., Dinis, A., Keshari, V., Novak, R., and Levin, M. (2020)
npj Regenerative Medicine, 5: 2
Toward Decoding Bioelectric Events in Xenopus Embryogenesis: New Methodology for Tracking Interplay between Calcium and Resting Potentials In Vivo
McMillen, P., Novak, R., and Levin, M. (2020)
Journal of Molecular Biology, 432(2): 605-620 [cover]
Formin, an opinion
Davison, A., McDowell, G. S., Holden, J. M., Johnson, H. F., Wade, C. M., Chiba, S., Jackson, D. J., Levin, M., and Blaxter, M. L. (2020)
Development, 147: dev187427
Optogenetically induced cellular habituation in non-neuronal cells
Bonzanni, M., Rouleau, N., Levin, M., and Kaplan, D. L. (2020)
PLOS One, 15(1): e0227230
A Scalable Pipeline for Designing Reconfigurable Organisms
Kriegman, S., Blackiston, D., Levin, M., and Bongard, J. (2020)
Proceedings of the National Academy of Sciences of the United States, 117(4): 1853-1859
Assessment of Enrichment of Human Mesenchymal Stem Cells Based on Plasma and Mitochondrial Membrane Potentials
Kamaldinov, T., Erndt-Marino, J., Levin, M., Kaplan, D. L., and Hahn, M. S. (2020)
Bioelectricity, 2(1): 21-32
The Biophysics of Regenerative Repair Suggests New Perspectives on Biological Causation
Levin, M. (2020)
BioEssays, 42(2): 1900146
Bioelectrical model of head-tail patterning based on cell ion channels and intercellular gap junctions
Cervera, J., Meseguer, S., Levin, M., and Mafe, S. (2020)
Bioelectrochemistry, 132: 107410
Morphological Coordination: A Common Ancestral Function Unifying Neural and Non-Neural Signaling
Fields, C., Bischof, J., and Levin, M. (2020)
Physiology, 35: 16-30
Post-SSRI Sexual Dysfunction: a bioelectric mechanism?
Healy, D., Faber, C., Lapalme, J., and Levin, M. (2020)
Bioelectricity, 2(1): 7-13
How to understand cells, tissues and organisms as agents with agendas
Levin, M., and Dennett, D. C. (2020)
Aeon Essays
Defined extracellular ionic solutions to study and manipulate the cellular resting membrane potential
Bonzanni, M., Payne, S. L., Adelfio, M., Kaplan, D. L., Levin, M., and Oudin, M. J. (2020)
Biology Open, 9(1): bio048553
2019
Endogenous Bioelectrics in Development, Cancer, and Regeneration: Drugs and Bioelectronic Devices as Electroceuticals for Regenerative Medicine
Levin, M., Selberg, J., and Rolandi, M. (2019)
iScience, 22: 519–533
Modeling somatic computation with non-neural bioelectric networks
Manicka, S., and Levin, M. (2019)
Scientific Reports 9: 18612
Opinion: Interdisciplinary Approach Needed to Crack Morphogenesis
Finkelstein J., McLaughlin K., and Levin M. (2019)
The Scientist, December 2019
The Computational Boundary of a 'Self': Developmental Bioelectricity Drives Multicellularity and Scale-Free Cognition
Levin, M. (2019)
Frontiers in Psychology, 10: 2688
Regenerative Adaptation to Electrochemical Perturbation in Planaria: A Molecular Analysis of Physiological Plasticity
Emmons-Bell, M., Durant, F., Tung, A., Pietak, A., Miller, K., Kane, A., Martyniuk, C. J., Davidian, D., Morokuma, J., and Levin, M. (2019)
iScience, 22: 147-165
L-type voltage-gated Ca2+ channel CaV1.2 regulates chondrogenesis during limb development
Atsuta, Y., Tomizwa, R. R., Levin, M., and Tabin, C. J. (2019)
Proceedings of the National Academy of Sciences of the United States, 116(43): 21592-21601
Hyperosmolar potassium inhibits myofibroblast conversion and reduces scar tissue formation
Grasman, J., Williams, M., Razis, C., Bonzanni, M., Golding, A., Cairns, D. M., Levin, M., and Kaplan, D. L. (2019)
ACS Biomaterials Science & Engineering, 5(10): 5327-5336
Managing Ideas, People, and Projects: Organizational Tools and Strategies for Researchers
Levin, S., and Levin, M. (2019)
iScience, 20: 278-291
Bioelectric control of metastasis in solid tumors
Payne, S. L., Levin, M., and Oudin, M. J. (2019)
Bioelectricity, 1(3): 114-130
Somatic Multicellularity as a Satisficing Solution to the Prediction-Error Minimization Problem
Fields, C., and Levin, M. (2019)
Communicative & Integrative Biology, 12(1): 119-132
A flow through device for simultaneous dielectrophoretic cell trapping and AC electroporation
Punjiya, M., Nehad, H. R., Mathews, J., Levin, M., and Sonkusale, S. (2019)
Scientific Reports, 9: 11988
Bioelectrical controls of morphogenesis: from ancient mechanisms of cell coordination to biomedical opportunities
Whited, J., and Levin, M. (2019)
Current Opinion in Genetics & Development, 57: 61-69 [cover]
Reverse-engineering growth and form in Heidelberg
Levin, M., and Martinez-Arias, A. (2019)
Development, 146(14): dev177261
Automated Shapeshifting for Function Recovery in Damaged Robots
Kriegman, S., Walker, S., Shah, D. S., Kramer-Bottiglio, R., and Bongard, J. (2019)
Proceedings of Robotics: Science and Systems XV: 28
From non-excitable single-cell to multicellular bioelectrical states supported by ion channels and gap junction proteins: electrical potentials as distributed controllers
Cervera, C., Pai, V. P., Levin, M., and Mafe, S. (2019)
Progress in Biophysics and Molecular Biology, 149: 39-53 [cover]
On the generalization of habituation: how discrete biological systems respond to repetitive stimuli
Bonzanni, M., Rouleau, N., Levin, M., and Kaplan, D. (2019)
BioEssays, 41(7): 1900028
Live Imaging of Intracellular pH in Planarians Using the Ratiometric Fluorescent Dye SNARF-5F-AM
Beane, W. S., Adams, D. S., Morokuma, J., and Levin, M. (2019)
Biology Methods and Protocols, 4(1): bpz005
Synchronization of Bioelectric Oscillations in Networks of Nonexcitable Cells: From Single-Cell to Multicellular States
Cervera, J., Manzanares, J. A., Mafe, S., and Levin, M. (2019)
Journal of Physical Chemistry B, 123(18): 3924-3934 [cover]
The Cognitive Lens: a primer on conceptual tools for analysing information processing in developmental and regenerative morphogenesis
Manicka, S., and Levin, M. (2019)
Philosophical Transactions of the Royal Society B, 374: 20180369
Neural control of body-plan axis in regenerating planaria
Pietak, A., Bischof, J., LaPalme, J., Morokuma, J., and Levin, M. (2019)
PLOS Computational Biology, 15(4): e1006904
A Call for a Better Understanding of Causation in Cell Biology
Bizzari, M., Brash, D., Briscoe, J., Grieneisen, V., Stern, C. D., and Levin, M. (2019)
Nature Reviews Molecular Cell Biology, 20(5): 261-262
Membrane potential depolarization alters calcium flux and phosphate signaling during osteogenic differentiation of human mesenchymal stem cells
Sundelacruz, S., Moody, A. T., Levin, M., and Kaplan, D. (2019)
Bioelectricity, 1(1): 56-66
Toward modeling regeneration via adaptable echo state networks
Hammelman, J., Siegelmann, H., Manicka, S., and Levin, M. (2019)
in A. Adamatzky, S. Akl, and G. Sirakoulis (Eds.), From parallel to emergent computing, Chapter 6, pages 117-133, CRC Press: Boca Raton, FL
Selective Serotonin Reuptake Inhibitor Use During Pregnancy and Major Malformations: The Importance of Serotonin for Embryonic Development and the Effect of Serotonin Inhibition on the Occurrence of Malformations
Berard, A., Levin, M., Sadler, T., and Healy, D. (2019)
Bioelectricity, 1(1): 18-29
Effects of ivermectin exposure on regeneration of D. dorotocephala planaria: exploiting human-approved ion channel drugs as morphoceuticals
Ferenc, N. N., and Levin, M. (2019)
Macromolecular Bioscience, 19(3): 1800237 [cover]
Planarian Regeneration as a Model of Anatomical Homeostasis: Recent Progress in Biophysical and Computational Approaches
Levin, M., Pietak, A., and Bischof, J. (2019),
Seminars in Cell and Developmental Biology, 87: 125-144
The role of early bioelectric signals in the regeneration of planarian anterior/posterior polarity
Durant, F., Bischof, J., Fields, C., Morokuma, J., LaPalme, J., Hoi, A., and Levin, M. (2019)
Biophysical Journal, 116(5): 948-961
EDEn – Electroceutical Design Environment: Ion Channel Tissue Expression Database with Small Molecule Modulators
Churchill, C. D. M., Winter, P., Tuszynski, J. A., and Levin, M. (2019)
iScience, 11: 42-56
2018
Multiscale Memory and Bioelectric Error Correction in the Cytoplasm-Cytoskeleton-Membrane System
Fields, C., and Levin, M. (2018)
Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 10(2): e1410 [cover]
A Computational Framework for Autonomous Self-repair Systems
Minh-Thai, T. N., Aryal, J., Samarasinghe, S., and Levin, M. (2018)
in Mitrovic, T., Xue, B., and Li, X. (Eds.), AI 2018: Advances in Artificial Intelligence, p153-159. Lecture Notes in Computer Science, vol 11320. Springer, Cham
Ahead of the Curve: Hidden Breakthroughs in the Biosciences, Vol 2
Adams, D. S., and Levin, M. (2018)
IOP Publishing Ltd: Bristol, UK [cover]
The bacterial metabolite indole inhibits regeneration of the planarian flatwork Dugesia japonica
Lee, F. J., Williams, K. B., Levin, M., and Wolfe, B. E. (2018)
iScience, 10: 135-148
Brief Local Application of Progesterone via a Wearable Bioreactor Induces Long-Term Regenerative Response in Adult Xenopus Hindlimb
Herrera-Rincon, C., Golding, A. S., Moran, K. M., Harrison, C., Martyniuk, C. J., Guay, J. A., Zaltsman, J., Carabello, H., Kaplan, D. L., and Levin, M. (2018)
Cell Reports, 25(6): 1593-1609
Perspective: the promise of multi-cellular engineered living systems
Kamm, R. D., Bashir, R., Arora, N., Dar, R. D., Gilette, M. U., Griffith, L. G., Kemp, M. L., Kinlaw, K., Levin, M., Martin, A. C., McDevitt, T. C., Nerem, R. M., Powers, M. J., Saif, T. A., Sharpe, J., Takayama, S., Takeuchi, S., Weiss, R., Ye, K., Yevick, H. G., and Zaman, M. H. (2018)
APL Bioengineering, 2(4): 040901
Ivermectin promotes peripheral nerve regeneration during wound healing
Cairns, D. M., Giordano, J. E., Conte, S., Levin, M., and Kaplan, D. L. (2018)
ACS Omega, 3(10): 12392-12402
Activating PAX gene family paralogs to complement PAX5 leukemia driver mutations
Hart, M. R., Anderson, D. J., Porter, C. C., Neff, T., Levin, M., and Horwitz, M. S. (2018)
PLoS Genetics, 14(9): 1007642
Cross-limb Communication During Xenopus Hind-limb Regenerative Response: Non-Local Bioelectric Injury Signals
Busse, S. M., McMillen, P. T., and Levin, M. (2018)
Development, 145(19): dev164210
Pattern Regeneration in Coupled Networks
Moore, D. G., Walker, S. I., and Levin, M. (2018)
in T. Ikegami, N. Virgo, O. Witkowski, M. Oka, R. Suzuki, and H. Iizuka (Eds.), ALIFE 2018: The 2018 Conference on Artificial Life. MIT Press: Tokyo, p. 204-205
Modeling Cell Migration in a Simulated Bioelectrical Signaling Network for Anatomical Regeneration
Ferreira, G. B. S., Scheutz, M., and Levin, M. (2018)
in T. Ikegami, N. Virgo, O. Witkowski, M. Oka, R. Suzuki, and H. Iizuka (Eds.), ALIFE 2018: The 2018 Conference on Artificial Life. MIT Press: Tokyo, p. 194-201
From Physics to Pattern: Uncovering Pattern Formation in Tissue Electrophysiology
Brodsky, M., and Levin, M. (2018)
in T. Ikegami, N. Virgo, O. Witkowski, M. Oka, R. Suzuki, and H. Iizuka (Eds.), ALIFE 2018: The 2018 Conference on Artificial Life. MIT Press: Tokyo, p. 351-358
Inform: Efficient Information-Theoretic Analysis of Collective Behaviors
Moore, D. G., Valentini, G., Walker, S. I., and Levin, M. (2018)
Frontiers in Robotics and AI, 5: 60
Embodying Markov blankets. Comment on 'Answering Schrödinger's question: A free-energy formulation' by Maxwell James Désormeau Ramstead et al
Pezzulo, G., and Levin, M. (2018)
Physics of Life Reviews, 24: 32-36
Bioelectrical coupling in multicellular domains regulated by gap junctions: a conceptual approach
Cervera, J., Pietak, A., Levin, M., and Mafe, S. (2018)
Bioelectrochemistry, 123: 45-61 [cover]
PDF
Bioelectrical control of positional information in development and regeneration: a review of conceptual and computational advances
Pietak, A., and Levin, M. (2018)
Progress in Biophysics and Molecular Biology, 137: 52-68
The Body Electric 2.0: Recent Advances in Developmental Bioelectricity for Regenerative and Synthetic Bioengineering
Mathews, J., and Levin, M. (2018)
Current Opinion in Biotechnology, 52: 134-144
Avian models and the study of invariant asymmetry: how the chicken and the egg taught us to tell right from left
Monsoro-Burq, A. H., and Levin, M. (2018)
International Journal of Developmental Biology, 62(1-3): 63-77
Are planaria individuals? What regenerative biology is telling us about the nature of multicellularity
Fields, C., and Levin, M. (2018)
Evolutionary Biology, 45(3): 237-247
HCN2 Rescues brain defects by enforcing endogenous voltage pre-patterns
Pai, V. P., Pietak, A., Willocq, V., Ye, B., Shi, N-Q., and Levin, M. (2018)
Nature Communications, 9(1): 998
Inverse Drug Screening of Bioelectric Signaling and Neurotransmitter Roles: Illustrated Using a Xenopus Tail Regeneration Assay
Sullivan, K. G., and Levin, M. (2018)
Cold Spring Harbor Protocols, 2018(3): 154-163
The bioelectric code: An ancient computational medium for dynamic control of growth and form
Levin, M., and Martyniuk, C. J. (2018)
BioSystems, 164: 76-93
Niclosamide rescues microcephaly in a humanized in vivo model of Zika infection using human induced neural stem cells
Cairns, D. M., Boorgu, D. S. S. K., Levin, M., and Kaplan, D. L. (2018)
Biology Open, 7(1): bio031807
Booting up the organism during development: pre-behavioral functions of the vertebrate brain in guiding body morphogenesis
Herrera-Rincon, C., and Levin, M. (2018)
Communicative & Integrative Biology, 11(1): e1433440 [cover]
Slime mould: the fundamental mechanisms of biological cognition
Vallverdu, J., Castro, O., Mayne, R., Talanov, M., Levin, M., Baluska, F., Gunji, Y., Dussutour, A., Zenil, H., and Adamatzky, A. (2018)
BioSystems, 165: 57-70
Inform: a toolkit for information-theoretic analysis of complex systems
Moore, D. G., Valentini, G., Walker, S. I., and Levin, M. (2018)
Proceedings of the 2017 IEEE Symposium Series on Computational Intelligence (SSCI), 3258-3265
Introducing Simulated Stem Cells into a Bio-Inspired Cell-Cell Communication Mechanism for Structure Regeneration
Ferreira, G. B. S., Scheutz, M., and Levin, M. (2018)
Proceedings of the 2017 IEEE Symposium Series on Computational Intelligence (SSCI), 2778-2785
2017
Ion channel and neurotransmitter modulators as electroceutical approaches to the control of cancer
Tuszynski, J., Tilli, T. M., and Levin, M. (2017)
Current Pharmaceutical Design, 23(32): 4827-4841
The brain is required for normal muscle and nerve patterning during early Xenopus development
Herrera-Rincon, C., Pai, V. P., Moran, K. M., Lemire, J. M., and Levin, M. (2017)
Nature Communications, 8(1): 587
Coordinating heart morphogenesis: A novel role for Hyperpolarization-activated cyclic nucleotidegated (HCN) channels during cardiogenesis in Xenopus laevis
Pitcairn, E., Harris, H., Epiney, J., Pai, V. P., Lemire, J. M., Ye, B., Shi, N-Q., Levin, M., and McLaughlin, K. A. (2017)
Communicative & Integrative Biology, 10(3): e1309488 [cover]
Bioelectric Gene and Reaction Networks: Computational Modeling of Genetic, Biochemical, and Bioelectrical Dynamics in Pattern Regulation
Pietak, A. M., and Levin, M. (2017)
Journal of the Royal Society Interface, 14(134): 20170425 [cover]
Bioelectric Signaling in Regeneration: Mechanisms of Ionic Controls of Growth and Form
McLaughlin, K. A., and Levin, M. (2017)
Developmental Biology, 433(2): 177-189
HCN4 Ion Channel Function is Required for Early Events that Regulate Anatomical Left-Right Patterning in a Nodal- and Lefty Asymmetric gene Expression-Independent Manner
Pai, V. P., Willocq, V., Pitcairn, E. J., Lemire, J. M., Paré, J-F., Shi, N-Q., McLaughlin, K. A., and Levin, M. (2017)
Biology Open, 6(10): 1445-1457
Cancer as a Disorder of Patterning Information: computational and biophysical perspectives on the cancer problem
Moore, D., Walker, S., and Levin, M. (2017)
Convergent Science Physical Oncology, 3(4): 043001
Repeated removal of developing limb buds permanently reduces appendage size in the highly regenerative axolotl
Bryant, D. M., Sousounis, K., Farkas, J. E., Bryant, S., Thao, N., Guzikowski, A. R., Monaghan, J. R., Levin, M., and Whited, J. L. (2017)
Developmental Biology, 424(1): 1-9 [cover]
Using optogenetics in vivo to stimulate regeneration
Adams, D. S., Tseng. A-S., and Levin, M. (2017)
in K. Appasani (Ed.), Optogenetics: From Neuronal Function to Mapping and Disease Biology, Cambridge University Press: Cambridge, UK, pp. 66-76
Investigating the Effects of Noise on a Cell-to-Cell Communication Mechanism for Structure Regeneration
Ferreira, G. B., Scheutz, M., and Levin, M. (2017)
in C. Knibbe, D. Parsons, D. Misevic, J. Rouzaud-Cornaba, N. Bredèche, S. Hassas, O. Simonin, and H. Soula (Eds.), Proceedings of the 14th European Conference on Artificial Life (ECAL 2017), Lyon, France, pp. 170-177
The Zahn Drawings: new illustrations of Xenopus embryo and tadpole stages for studies of craniofacial development
Zahn, N., Levin, M., and Adams, D. S. (2017)
Development, 144(15): 2708-2713 [cover]
Microfluidic Platform to Study Intercellular Connectivity Through on-Chip Electrical Impedance Measurement
Dungan, J., Mathews, J., Levin, M., and Koomson, V. (2017)
IEEE 60th International Midwest Symposium on Circuits and Systems, Boston, MA, p.56-69
Bioelectric regulation of innate immune system function in regenerating and intact Xenopus laevis
Paré, J-F., Martyniuk, C. J., and Levin, M. (2017)
npj Regenerative Medicine, 2: 15
Long-Term, Stochastic Editing of Regenerative Anatomy via Targeting Endogenous Bioelectric Gradients
Durant, F., Morokuma, J., Fields, C., Williams, K., Adams, D. S., and Levin, M. (2017)
Biophysical Journal, 112(10): 2231-2243 [cover]
Space travel has effects on planarian regeneration that cannot be explained by a null hypothesis
Levin, M., Morokuma, J., and Finkelstein, J. (2017)
Regeneration, 4(4): 156-158
Planarian regeneration in space: persistent anatomical, behavioral, and bacteriological changes induced by space travel
Morokuma, J., Durant, F. R., Williams, K. B., Finkelstein, J. M., Blackiston, D. J., Clements, T., Reed, D. W., Roberts, M., Jain, M., Kimel, K., Trayger, S. A., Wolfe, B. E., and Levin, M. (2017)
Regeneration, 4(2): 85-102 [cover]
Gap Junctional Signaling in Pattern Regulation: physiological network connectivity instructs growth and form
Mathews, J., and Levin, M. (2017)
Developmental Neurobiology, 77(5): 643-673
Endogenous Bioelectric Signaling Networks: Exploiting Voltage Gradients for Control of Growth and Form
Levin, M., Pezzulo, G., and Finkelstein, J. M. (2017)
Annual Review of Biomedical Engineering, 19: 353-87
IK channel activation increases tumor growth and induces differential behavioral responses in two breast epithelial cell lines
Thurber, A. E., Nelson, M., Frost, C. L., Levin, M., Brackenbury, W. J., and Kaplan, D. L. (2017)
Oncotarget, 8(26): 42382-42397
Serotonergic stimulation induces nerve growth and promotes visual learning via posterior eye grafts in a vertebrate model of induced sensory plasticity
Blackiston, D., Vien, K., and Levin, M. (2017)
npj Regenerative Medicine, 2: 8
Discovering novel phenotypes with automatically inferred dynamic models: partial melanocyte conversion in Xenopus
Lobo, D., Lobikin, M., and Levin, M. (2017)
Scientific Reports, 7: 41339
Reversals of bodies, brains, and behavior: quantitative analysis of laterality and its disturbance in model species
Blackiston, D. J., and Levin, M. (2017)
in L. J. Rogers and G. Vallortigara (Eds.), Lateralized Brain Functions: Methods in Human and Non-human Species, "Neuromethods", W. Walz (Ed.), 122: 667-694
Modeling regenerative processes with Membrane Computing
Garcia-Quismondo, M., Levin, M., and Lobo, D. (2017)
Information Sciences, 381: 229-249
Computing a worm: reverse-engineering planarian regeneration
Lobo, D., and Levin, M. (2017)
in Adamatzky, A. (Ed.), Advances in Unconventional Computing. Emergence, Complexity and Computation, vol 23, Springer: Cham, pp. 637-654
A Computational Model of Planarian Regeneration
De, A., Chakravarthy, V. S., and Levin, M. (2017)
International Journal of Parallel, Emergent, and Distributed Systems, 32(4): 331-347
2016
Ahead of the Curve: Hidden Breakthroughs in the Biosciences, Vol. 1
Levin, M., and Adams, D. S. (2016)
IOP Publishing: Bristol, UK [cover]
Introduction to provocative questions in Left-Right asymmetry
Levin, M., Klar, A. J. S., and Ramsdell, A. (2016)
Philosophical Transactions of the Royal Society B, 371(1710): 20150399
From cytoskeletal dynamics to organ asymmetry: a nonlinear, regulative pathway underlies left-right patterning
McDowell, G., Rajadurai, S., and Levin, M. (2016)
Philosophical Transactions of the Royal Society B, 371(1710): 20150409 [cover]
Top-down models in biology: explanation and control of complex living systems above the molecular level
Pezzulo, G., and Levin, M. (2016)
Journal of the Royal Society Interface, 13(124): 20160555
Bioelectrical coordination of cell activity toward anatomical target states: an engineering perspective on regeneration
Herrera-Rincon, C., Guay, J., and Levin, M. (2016)
in D. Gardiner (Ed.), Regenerative Engineering and Developmental Biology: Principles and Applications, CRC Press: Boca Raton FL, Chapter 4, pp. 55-112
Vertically and horizontally-transmitted memories – the fading boundaries between regeneration and inheritance in planaria
Neuhof, M., Levin, M., and Rechavi, O. (2016)
Biology Open, 5(9): 1177-1188 [cover]
Dynamic structure discovery and repair for 3D cell assemblages
Ferreira, G., Smiley, M., Scheutz, M., and Levin, M. (2016)
Proceedings of the Fifteenth International Conference on the Synthesis and Simulation of Living Systems (ALIFEXV), pp. 352-359
A Level Set Approach to Simulating Xenopus laevis Tail Regeneration
Serlin, Z., Rife, J., and Levin, M. (2016)
Proceedings of the Fifteenth International Conference on the Synthesis and Simulation of Living Systems (ALIFEXV), pp. 528-535
Exploring Instructive Physiological Signaling with the Bioelectric Tissue Simulation Engine (BETSE)
Pietak, A., and Levin, M. (2016)
Frontiers in Bioengineering and Biotechnology, 4: 55
On Having No Head: Cognition throughout Biological Systems
Baluska, F., and Levin, M. (2016)
Frontiers in Psychology, 7: 902
Genome-wide analysis reveals conserved transcriptional responses downstream of resting potential change in Xenopus embryos, axolotl regeneration, and human mesenchymal cell differentiation
Pai, V. P., Martyniuk, C. J., Echeverri, K., Sundelacruz, S., Kaplan, D. L., and Levin, M. (2016)
Regeneration, 3(1): 3-25
A Tunable Silk Hydrogel Device for Studying Limb Regeneration in Adult Xenopus laevis
Golding, A., Guay, J. A., Herrera-Rincon, C., Levin, M., and Kaplan, D. L. (2016)
PLoS One, 11(6): e0155618
Physiological Inputs Regulate Species-Specific Anatomy During Embryogenesis and Regeneration
Sullivan, K. G., Emmons-Bell, M., and Levin, M. (2016)
Communicative & Integrative Biology, 9(4): e1192733 [cover]
Computational discovery and in vivo validation of hnf4 as a regulatory gene in planarian re-generation
Lobo, D., Morokuma, J., and Levin, M. (2016)
Bioinformatics, 32(17): 2681-2685
Color and intensity discrimination in Xenopus laevis tadpoles
Rothman, G., Blackiston, D., and Levin, M. (2016)
Animal Cognition, 19(5): 911-919
Telocytes in their context with other intercellular communication agents
Edelstein, L., Fuxe, K., Levin, M., Popescu, B., and Smythies, J. (2016)
Seminars in Cell and Developmental Biology, 55: 9-13
Formin Is Associated with Left-Right Asymmetry in the Pond Snail and the Frog
Davison, A., McDowell, G. S., Holden, J. M., Johnson, H. F., Koutsovoulos, G. D., Liu, M. M., Hulpiau, P., Van Roy, F., Wade, C. W., Banerjee, R., Yang, F., Chiba, S., Davey, J. W., Jackson, D. J., Levin, M., and Blaxter, M. L. (2016)
Current Biology, 26(5): 654-660 [cover]
Physiological controls of large-scale patterning in planarian regeneration: a molecular and computational perspective on growth and form
Durant, F., Lobo, D., Hammelman, J., and Levin, M. (2016)
Regeneration, 3(2): 78-102 [cover]
Neurotransmitter signaling pathways required for normal development in Xenopus laevis embryos: a pharmacological survey screen
Sullivan, K. G., and Levin, M. (2016)
Journal of Anatomy, 229(4): 483-502 [cover]
Use of genetically encoded, light-gated ion translocators to control tumorigenesis
Chernet, B. T., Adams, D. S., Lobikin, M., and Levin, M. (2016)
Oncotarget, 7(15): 19575-19588
Bioelectric signaling via potassium channels: a mechanism for craniofacial dysmorphogenesis in KCNJ2-associated Andersen-Tawil Syndrome
Adams, D. S., Uzel, S. G. M., Akagi, J., Wlodkowic, D., Andreeva, V., Yelick, P. C., Devitt-Lee, A., Paré, J-F., and Levin, M. (2016)
Journal of Physiology, 594(12): 3245-3270 [cover]
Conserved roles for cytoskeletal components in determining laterality
McDowell, G. S., Lemire, J. M., Paré, J-F., Cammarata, G., Lowery, L. A., and Levin, M. (2016)
Integrative Biology, 8(3): 267-286 [cover]
Bioelectric modulation of macrophage polarization
Li, C., Levin, M., and Kaplan, D. (2016)
Scientific Reports, 6: 21044
On chirality of slime mould
Dimonte, A., Adamatzky, A., Erokhin, V., and Levin, M. (2016)
BioSystems, 140: 23-27
MoCha: molecular characterization of unknown pathways
Lobo, D., Hammelman, J., and Levin, M. (2016)
Journal of Computational Biology, 23(4): 291-297
Towards a physarum learning chip
Whiting, J. G. H., Jones, J., Bull, L., Levin, M., and Adamatzky, A. (2016)
Scientific Reports, 6: 19948
Artificial neural networks as models of robustness in development and regeneration: stability of memory during morphological remodeling
Hammelman, J., Lobo, D., and Levin, M. (2016)
in S. Shanmuganathan and S. Samarasinghe (Eds.), Artificial Neural Network (ANN) Modeling, vol. 628, pp. 45-65
2015
Comparison of the depolarization response of human mesenchymal stem cells from different donors
Sundelacruz, S., Levin M., and Kaplan, D. L. (2015)
Scientific Reports, 5: 18279
Gap junctional blockade stochastically induces different species-specific head anatomies in genetically wild-type Girardia dorotocephala flatworms
Emmons-Bell, M., Durant, F., Hammelman, J., Bessonov, N., Volpert, V., Morokuma, J., Pinet, K., Adams, D. S., Pietak, A., Lobo, D., and Levin, M. (2015)
International Journal of Molecular Sciences, 16(11): 27865-27896 [cover]
Re-membering the body: applications of computational neuroscience to the top-down control of regeneration of limbs and other complex organs
Pezzulo, G., and Levin, M. (2015)
Integrative Biology, 7(12): 1487-1517 [cover]
Automatic neuron segmentation and neural network analysis method for phase contrast microscopy images
Pang, J., Özkucur, N., Ren, M., Kaplan, D. L., Levin, M., and Miller, E. L. (2015)
Biomedical Optics Express, 6(11): 4395-4416
Serotonergic regulation of melanocyte conversion: A bioelectrically regulated network for stochastic all-or-none hyperpigmentation
Lobikin, M., Lobo, D., Blackiston, D. J., Martyniuk, C. J., Tkachenko, E., and Levin, M. (2015)
Science Signaling, 8(397): ra99
Bioelectric memory: modeling resting potential bistability in amphibian embryos and mammalian cells
Law, R., and Levin, M. (2015)
Theoretical Biology and Medical Modelling, 12(1): 22
H+/K+-ATPase activity is required for biomineralization in sea urchin embryos
Schatzberg, D., Lawton, M., Hadyniak, S. E., Ross, E. J., Carney, T., Beane, W. S., Levin, M., and Bradham, C. A. (2015)
Developmental Biology, 406(2): 259-270
Target morphology and cell memory: a model of regenerative pattern formation
Bessonov, N., Levin, M., Morozova, N., Reinberg, N., Tosenberger, A., and Volpert, V. (2015)
Neural Regeneration Research, 10(12): 1901-1905 [cover]
The stability of memories during brain remodeling: A perspective
Blackiston, D. J., Shomrat, T., and Levin, M. (2015)
Communicative & Integrative Biology, 8(5): e1073424 [cover]
Local and long-range endogenous resting potential gradients antagonistically regulate apoptosis and proliferation in the embryonic CNS
Pai, V. P., Lemire, J. M., Chen, Y., Lin G., and Levin, M. (2015)
International Journal of Developmental Biology, 59(7-9): 327-340
Selective depolarization of transmembrane potential alters muscle patterning and muscle cell localization in embryonic Xenopus Laevis
Lobikin, M., Paré, J-F., Kaplan, D. L., and Levin, M. (2015)
International Journal of Developmental Biology, 59(7-9): 303-311 [cover]
Inferring regulatory networks from experimental morphological phenotypes: a computational method reverse-engineers planarian regeneration
Lobo, D., and Levin, M. (2015)
PLoS Computational Biology, 11(6): e1004295
A conceptual model of morphogenesis and regeneration
Tosenberger, A., Bessonov, N., Levin, M., Reinberg, N., Volpert, V., and Morozova, N. (2015)
Acta Biotheoretica, 63(3): 283-294
Gap junctions: versatile mediators of long-range developmental signals
Levin, M. (2015)
The Node
Nerves read the electrical typography of their microenvironment in making growth decisions
Levin, M. (2015)
The Node
Knowing one's place: a free energy approach to pattern regulation
Friston, K., Levin, M., Sengupta B., and Pezzulo, G. (2015)
Journal of the Royal Society Interface, 12(105): 20141383
Endogenous gradients of resting potential instructively pattern embryonic neural tissue via Notch signaling and regulation of proliferation
Pai, V., Lemire, J. M., Paré, J-F., Lin, G., Chen, Y., and Levin, M. (2015)
Journal of Neuroscience, 35(10): 4366-4385
Membrane potential depolarization causes alterations in neuron arrangement and connectivity in cocultures
Özkucur, N., Quinn, K. P., Pang, J. C., Du, C., Georgakoudi, I., Miller, E., Levin, M., and Kaplan, D. L. (2015)
Brain and Behavior, 5(1): 24-38
On a model of pattern recognition based on cell memory
Bessonov, N., Levin, M., Morozova, N., Reinberg, N., Tosenberger, A., and Volpert, V. (2015)
PLoS One, 10(2): e0118091
A novel method for inducing nerve growth via modulation of host resting potential
Blackiston, D., Anderson, G. M., Rahman, N., Bieck, C., and Levin, M. (2015)
Neurotherapeutics, 12(1): 170-184
Long-range gap junctional signaling controls oncogene-mediated tumorigenesis in Xenopus laevis embryos
Chernet, B. T., Fields, C., and Levin, M. (2015)
Frontiers in Physiology, 5: 519
2014
Molecular bioelectricity: how endogenous voltage potentials control cell behavior and instruct pattern regulation in vivo
Levin, M. (2014)
Molecular Biology of the Cell, 25(24): 3835-3850
Optogenetic Control of Apoptosis in Targeted Tissues of Xenopus laevis Embryos
Jewhurst, K., Levin, M., and McLaughlin, K. A. (2014)
Journal of Cell Death, 7: 25-31
Optogenetics in developmental biology: using light to control ion flux-dependent signals in Xenopus embryos
Adams, D.S., Lemire, J. M., Kramer, R. H., and Levin, M. (2014)
International Journal of Developmental Biology, 58(10-12): 851-861
Left-right patterning in Xenopus conjoined twin embryos requires serotonin signaling and gap junctions
Vandenberg, L. N., Blackiston, D. J., Rea, A. C., Dore, T. M., and Levin, M. (2014)
International Journal of Developmental Biology, 58(10-12): 799-809
Fishing on chips: up-and-coming technological advances in analysis of zebrafish and Xenopus embryos
Zhu, F., Skommer, J., Huang, Y., Akagi, J., Adams, D. S., Levin, M., Hall, C. J., Crosier, P. S., and Wlodkowic, D. (2014)
Cytometry A, 85(11): 921-932
Limbform: a functional ontology-based database of limb regeneration experiments
Lobo, D., Feldman, E. B., Shah, M., Malone, T. J., and Levin, M. (2014)
Bioinformatics, 30(24): 3598-3600
Depolarization of Cellular Resting Membrane Potential Promotes Neonatal Cardiomyocyte Proliferation In Vitro
Lan, J. Y., Williams, C., Levin, M., and Black, L. D. III (2014)
Cellular and Molecular Bioengineering, 7(3): 432-445
Bioelectrical mechanisms for programming growth and form: taming physiological networks for soft body robotics
Mustard, J., and Levin, M. (2014)
Soft Robotics, 1(3): 169-191
A bioinformatics expert system linking functional data to anatomical outcomes in limb regeneration
Lobo, D., Feldman, E. B., Shah, M., Malone, T., and Levin, M. (2014)
Regeneration, 1(2): 37-56
Design of a flexible component gathering algorithm for converting cell-based models to graph representations for use in evolutionary search
Budnikova, M., Habig, J. W., Cornia, N., Levin. M., Lobo, D., and Andersen, T. (2014)
BMC Bioinformatics, 15(1): 178
Transmembrane voltage potential of somatic cells controls oncogene-mediated tumorigenesis at long-range
Chernet, B., and Levin, M. (2014)
Oncotarget, 5(10): 3287-3306 [cover]
Alteration of bioelectrically controlled processes in the embryo: a teratogenic mechanism for anticonvulsants
Hernandez-Diaz S., and Levin, M. (2014)
Reproductive Toxicology, 47: 111-114
Bioelectric controls of stem cell function
Pai, V., and Levin, M. (2014)
in F. Calegari and C. Waskow (Eds.), Stem Cells: From Basic Research to Therapy, Volume 1, CRC Press: Boca Raton FL, Chapter 5, pp. 106-145
Endogenous bioelectrical networks store non-genetic patterning information during development and regeneration
Levin, M. (2014)
Journal of Physiology, 592(11): 2295-2305
A linear-encoding model explains the variability of the target morphology in regeneration
Lobo, D., Solano, M., Bubenik, G. A., and Levin, M. (2014)
Journal of the Royal Society Interface, 11(92): 20130918
Endogenous bioelectric cues as morphogenetic signals in vivo
Lobikin, M., and Levin, M. (2014)
in D. Fels, M. Cifra, and F. Scholkmann (Eds.), Fields of the Cell, Research Signpost: Kerala, India, Chapter 15, pp. 283-302
V-ATPase maintains neural stem cells in the developing mouse cortex
Lange, C., Prenninger, S., Knuckles, P., Taylor, V., Levin, M., and Calegari, F. (2014)
in S. Nakamuri (Ed.), Handbook of H+ ATPases, Pan Stanford Pte. Ltd: Singapore, pp. 413-430
2013
It's Never Too Early to Get It Right: A Conserved Role for the Cytoskeleton in Left-Right Asymmetry
Vandenberg, L. N., Lemire, J. M, and Levin, M. (2013)
Communicative & Integrative Biology, 6(6): e27155
Remembrance of Brains Past
Levin, M. (2013)
The Node
Light-activated serotonin for exploring its action in biological systems
Rea, A. C., Vandenberg, L. N., Ball, R. E., Snouffer, A. A., Hudson, A. G., Zhu, Y., McLain, D. E., Johnston, L. L., Lauderdale, J. D., Levin, M., and Dore, T. M. (2013)
Chemistry & Biology, 20(12): 1536-1546
Bioelectric modulation of wound healing in a 3D in vitro model of tissue-engineered bone
Sundelacruz, S., Li, C., Choi, Y. J., Levin, M., and Kaplan, D. L. (2013)
Biomaterials, 34(28): 6695-6705
Depolarization Alters Phenotype, Maintains Plasticity of Predifferentiated Mesenchymal Stem Cells
Sundelacruz, S., Levin, M., and Kaplan, D. L. (2013)
Tissue Engineering Part A, 19(17-18): 1889-1908
Endogenous voltage potentials and the microenvironment: bioelectric signals that reveal, induce, and normalize cancer
Chernet, B., and Levin, M. (2013)
Journal of Clinical and Experimental Oncology, Suppl 1: S1-002 [cover]
Reprogramming cells and tissue patterning via bioelectrical pathways: molecular mechanisms and biomedical opportunities
Levin, M. (2013)
Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 5(6): 657-676
An automated training paradigm reveals long-term memory in planaria and its persistence through head regeneration
Shomrat, T., and Levin, M. (2013)
Journal of Experimental Biology, 216(20): 3799-3810
Overview
Bioelectrical signaling has rich history
Levin, M. (2013)
Physics Today, 66(9): 11
Inversion of left-right asymmetry alters performance of Xenopus tadpoles in nonlateralized cognitive tasks
Blackiston, D. J., and Levin, M. (2013)
Animal Behaviour, 86(2): 459-466
A unified model for left-right asymmetry? Comparison and synthesis of molecular models of laterality
Vandenberg, L. N., and Levin, M. (2013)
Developmental Biology, 379(1): 1-15 [cover]
Towards a bioinformatics of patterning: a computational approach to understanding regulative morphogenesis
Lobo, D., Malone, T. J., and Levin, M. (2013)
Biology Open, 2(2): 156-169 [cover]
Rab GTPases are required for early orientation of the left-right axis in Xenopus
Vandenberg, L. N., Morrie, R. D., Seebohm, G., Lemire, J. M., and Levin, M. (2013)
Mechanisms of Development, 130(4-5): 254-271 [cover]
Endogenous Voltage Gradients as Mediators of Cell-Cell Communication: Strategies for Investigating Bioelectrical Signals During Pattern Formation
Adams, D. S., and Levin, M. (2013)
Cell and Tissue Research, 352(1): 95-122 [cover]
Ectopic eyes outside the head in Xenopus tadpoles provide sensory data for light-mediated learning
Blackiston, D. J., and Levin, M. (2013)
Journal of Experimental Biology, 216(6): 1031-1040
Planform: an application and database of graph-encoded planarian regenerative experiments
Lobo, D., Malone, T. J., and Levin, M. (2013)
Bioinformatics, 29(8): 1098-1100
Humane anesthesia and pain management in amphibian limb surgery of Rana pipiens
Koustubhan, P., Kaplan, D., and Levin, M. (2013)
Cold Spring Harbor Protocols, 2013(2): 149-155 [cover]
Transmembrane voltage potential is an essential cellular parameter for the detection and control of tumor development
Chernet, B. T., and Levin, M. (2013)
Disease Models & Mechanisms, 6(3): 595-607
Cracking the bioelectric code: probing endogenous ionic controls of pattern formation
Tseng, A-S., and Levin, M. (2013)
Communicative & Integrative Biology, 6(1): e22595 [cover]
Light-activation of the Archaerhodopsin H+ pump reverses age-dependent loss of vertebrate regeneration: sparking system-level controls in vivo
Adams, D. S., Tseng, A-S. and Levin, M. (2013)
Biology Open, 2(3): 306-313
Serotonin has early, cilia-independent roles in Xenopus left-right patterning
Vandenberg, L. N., Lemire, J. M., and Levin, M. (2013)
Disease Models and Mechanisms, 6(1): 261-268 [cover]
Bioelectric signaling regulates head and organ size during planarian regeneration
Beane, W. S., Morokuma, J., Lemire, J. M., and Levin, M. (2013)
Development, 140(2): 313-322
2012
Low frequency vibrations induce malformations in two aquatic species in a frequency-, waveform-, and direction-specific manner
Vandenberg, L. N., Stevenson, C., and Levin, M. (2012)
PLoS One, 7(12): e51473
Neurally derived tissues in Xenopus laevis embryos exhibit a consistent bioelectrical left-right asymmetry
Pai, V. P., Vandenberg, L. N., Blackiston, D. J., and Levin, M. (2012)
Stem Cells International, 2012: 353491
Resting potential, oncogene-induced tumorigenesis, and metastasis: the bioelectric basis of cancer in vivo
Lobikin, M., Chernet, B., Lobo, D., and Levin, M. (2012)
Physical Biology, 9(6): 065002 [cover]
Early nonciliary role for microtubule proteins in left–right patterning is conserved across kingdoms
Lobikin, M., Wang, G., Xu, J.-S., Hsieh, Y.-W., Chuang, C.-F., Lemire, J. M., and Levin, M. (2012)
Proceedings of the National Academy of Sciences of the United States, 109(31): 12586-12591
Transducing bioelectrical signals into epigenetic pathways during tadpole tail regeneration
Tseng, A.-S., and Levin, M. (2012)
Anatomical Record, 295(10): 1541-1551
Morphogenetic fields in embryogenesis, regeneration, and cancer: non-local control of complex patterning
Levin, M. (2012)
BioSystems, 109(3): 243-261
Normalized shape and location of perturbed craniofacial structures in the Xenopus tadpole reveal an innate ability to achieve correct morphology
Vandenberg, L. N., Adams, D. S., and Levin, M. (2012)
Developmental Dynamics, 241(5): 863-878 [cover]
Aversive training methods in Xenopus laevis: general principles
Blackiston, D. J., and Levin, M. (2012)
Cold Spring Harbor Protocols, 2012(5): 521-527
Inhibition of planar cell polarity extends neural growth during regeneration, homeostasis, and development
Beane, W. S., Tseng, A.-S., Morokuma, J. M., Lemire, J. M., and Levin, M. (2012)
Stem Cells and Development, 21(12): 2085-2094 [cover]
Photoconversion for Tracking the Dynamics of Cell Movement in Xenopus laevis Embryos
Chernet, B. T., Adams, D. S., and Levin, M. (2012)
Cold Spring Harbor Protocols, 2016(6): 683-690 [cover]
A versatile protocol for mRNA electroporation of Xenopus laevis embryos
Chernet, B. T., and Levin, M. (2012)
Cold Spring Harbor Protocols, 2012(4): 447-452
General principles for measuring resting membrane potential and ion concentration using fluorescent bioelectricity reporters
Adams, D. S., and Levin, M. (2012)
Cold Spring Harbor Protocols, 2012(4): 385-397 [cover]
Measuring resting membrane potential using the fluorescent voltage reporters DiBAC4(3) and CC2-DMPE
Adams, D. S., and Levin, M. (2012)
Cold Spring Harbor Protocols, 2012(4): 459-464
Transmembrane voltage potential controls embryonic eye patterning in Xenopus laevis
Pai, V., Aw, S., Shomrat, T., Lemire, J. M., and Levin, M. (2012)
Development, 139(2): 313-323
Molecular bioelectricity in developmental biology: new tools and recent discoveries
Levin, M. (2012)
BioEssays, 34(3): 205-217 [cover]
Polarity proteins are required for left-right axis orientation and twin-twin instruction
Vandenberg, L. N., and Levin, M. (2012)
Genesis, 50(3): 219-234
Regulation of Cell Behavior and Tissue Patterning by Bioelectrical Signals: challenges and opportunities for biomedical engineering
Levin, M., and Stevenson, C. (2012)
Annual Reviews in Biomedical Engineering, 14: 295-323
Modeling planarian regeneration: a primer for reverse-engineering the worm
Lobo, D., Beane, W., and Levin, M. (2012)
PLoS Computational Biology, 8(4): e1002481 [cover]
2011
Transmembrane potential of GlyCl-expressing instructor cells induces a neoplastic-like conversion of melanocytes via a serotonergic pathway
Blackiston, D., Adams, D. S., Lemire, J. M., Lobikin, M., and Levin, M. (2011)
Disease Models and Mechanisms, 4(1): 67-85 [cover]
A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration
Beane, W. S., Morokuma, J., Adams, D. S., and Levin, M. (2011)
Chemistry & Biology, 18(1): 77-89
The H(+) vacuolar ATPase maintains neural stem cells in the developing mouse cortex
Lange, C., Prenninger, S., Knuckles, P., Taylor, V., Levin, M., and Calegari, F. (2011)
Stem Cells and Development, 20(5): 843-850
Histone deacetylase activity is necessary for left-right patterning during vertebrate development
Carneiro, K., Donnet, C., Rejtar, T., Karger, B. L., Díaz, E., Kortagere, S., Lemire, J. M., and Levin, M. (2011)
BMC Developmental Biology, 11: 29
Low-frequency vibrations disrupt left-right patterning in the Xenopus embryo
Vandenberg, L. N., Pennarola, B. W., and Levin, M. (2011)
PLoS One, 6(8): e23306
Patterned femtosecond-laser ablation of Xenopus laevis melanocytes for studies of cell migration, wound repair, and developmental processes
Mondia, J. P., Adams, D. S., Orendorff, R. D., Levin, M., and Omenetto, F. (2011)
Biomedical Optics Express, 2(8): 2383-2391
Long-distance signals are required for morphogenesis of the regenerating Xenopus tadpole tail, as shown by femtosecond-laser ablation
Mondia, J. P., Levin, M., Omenetto, F. G., Orendorff, R. D., Branch, M. R., and Adams, D. S. (2011)
PLoS One, 6(9): e24953
HDAC activity is required during Xenopus tail regeneration
Tseng, A-S., Carneiro, K., Lemire, J. M., and Levin, M. (2011)
PLoS One, 6(10): e26382
Endogenous Bioelectric Signals as Morphogenetic Controls of Development, Regeneration, and Neoplasm
Levin, M. (2011)
in C. Pullar (Ed.), The Physiology of Bioelectricity in Development, Tissue Regeneration, and Cancer, CRC Press: Boca Raton FL, pp. 39-89
The wisdom of the body: future techniques and approaches to morphogenetic fields in regenerative medicine, developmental biology, and cancer
Levin, M. (2011)
Regenerative Medicine, 6(6): 667-673
2010
A second-generation device for automated training and quantitative behavior analyses of molecularly tractable model organisms
Blackiston, D., Shomrat, T., Nicolas, C. L., Granata, C., and Levin, M. (2010)
PLoS One, 5(12): e14370
Long-range Neural and Gap Junction Protein-mediated Cues Control Polarity During Planarian Regeneration
Oviedo, N. J., Morokuma, J., Walentek, P., Kema, I. P., Gu, M. B., Ahn, J. M., Hwang, J. S., Gojobori, T., and Levin, M. (2010)
Developmental Biology, 339(1): 188-199
Consistent left-right asymmetry cannot be Established by late organizers in Xenopus unless the late organizer is a conjoined twin
Vandenberg, L. N., and Levin, M. (2010)
Development, 137(7): 1095-1105 [cover]
The ATP-sensitive K+-channel (KATP) controls early left-right patterning in Xenopus and chick embryos
Aw, S., Koster, J., Pearson, W., Nicols, C., Shi, N. Q., Carneiro, K., and Levin, M. (2010)
Developmental Biology, 346(1): 39-53
Induction of vertebrate regeneration by a transient sodium current
Tseng, A-S., Beane, W. S., Lemire, J. M., Masi, A., and Levin, M. (2010)
Journal of Neuroscience, 30(39): 13192-13200 [cover]
BioDome regenerative sleeve for biochemical and biophysical stimulation of tissue regeneration
Hechavarria, D., Dewilde, A., Braunhut, S., Levin, M., and Kaplan, D. K. (2010)
Medical Engineering and Physics, 32(9): 1065-1073
High-throughput Xenopus laevis immunohistochemistry using agarose sections
Blackiston, D., Vandenberg, L. N., and Levin, M. (2010)
Cold Spring Harbor Protocols, 2010(12): 1364-1371
Far from solved: a perspective on what we know about early mechanisms of left-right asymmetry
Vandenberg, L. N., and Levin, M. (2010)
Developmental Dynamics, 239(12): 3131-3146 [cover]
2009
Molecular mechanisms establishing consistent left-right asymmetry during vertebrate embryogenesis
Aw, S., and Levin, M. (2009)
in I. E. C Sommer and R. S, Kahn (Eds.), Language Lateralization and Psychosis, Cambridge University Press: Cambridge UK, pp. 3-18
Is left-right asymmetry a form of planar cell polarity?
Aw, S., and Levin, M. (2009)
Development, 136(3): 355-366
Perspectives and open problems in the early phases of left-right patterning
Vandenberg, L., and Levin, M. (2009)
Seminars in Cell and Developmental Biology, 20(4): 456-463 [cover]
Particle tracking model of electrophoretic morphogen movement reveals stochastic dynamics of embryonic gradient
Zhang, Y., and Levin, M. (2009)
Developmental Dynamics, 238(8): 1923-1935
Left-right asymmetry in the chick embryo requires core planar cell polarity protein Vangl2
Zhang, Y., and Levin, M. (2009)
Genesis, 47(11): 719-728
Bioelectric mechanisms in regeneration: Unique aspects and future perspectives
Levin, M. (2009)
Seminars in Cell and Developmental Biology, 20(5): 543-556
Errors of Geometry: regeneration in a broader perspective
Levin, M. (2009)
Seminars in Cell and Developmental Biology, 20(6): 643-645
Regeneration: recent advances, major puzzles, and biomedical opportunities
Levin, M. (2009)
Seminars in Cell and Developmental Biology, 20(5): 515-516
Role of membrane potential in the regulation of cell proliferation and differentiation
Sundelacruz, S., Levin, M., Levin M., and Kaplan, D. L. (2009)
Stem Cell Reviews, 5(3): 231-46
Bioelectric controls of cell proliferation: ion channels, membrane voltage, and the cell cycle
Blackiston, D. J., K. McLaughlin, and Levin, M. (2009)
Cell Cycle, 8(21): 3527-3536 [cover]
2008
KCNQ1 and KCNE1 K+ channel components are involved in early left-right patterning in Xenopus embryos
Morokuma, J., Blackiston, D., and Levin, M. (2008)
Cellular Physiology and Biochemistry, 21(5-6): 357-372
Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling
Oviedo, N. J., Pearson, B. J., Levin, M., and Alvarado, A. S. (2008)
Disease Models and Mechanisms, 1(2-3): 131-143
Modulation of potassium channel confers a hyper-proliferative invasive phenotype on embryonic stem cells
Morokuma, J., Blackiston, D., Adams, D. S., Seebohm, G., Trimmer, B., and Levin, M. (2008)
Proceedings of the National Academy of Sciences of the United States, 105(43): 16608-16613
Membrane potential controls adipogenic and osteogenic differentiation of mesenchymal stem cells
Sundelacruz, S., Levin, M., and Kaplan, D. L. (2008)
PLoS One, 3(11): e3737
Live imaging of planarian membrane potential using DiBAC4(3)
Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M. (2008)
Cold Spring Harbor Protocols, 3(10): pdb.prot5055
Gene knockdown in planarians using RNA interference
Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M. (2008)
Cold Spring Harbor Protocols, 3(10): pdb.prot5054
Establishing and maintaining a colony of planarians
Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M. (2008)
Cold Spring Harbor Protocols, 3(10): pdb.prot5053
The planarian regeneration model as a context for the study of drug effects and mechanisms
Oviedo, N., and Levin, M. (2008)
in R. B. Raffa & S. M. Rawls (Eds.), Planaria: A Model for Drug Action and Abuse, RG Landes Co.: Austin, pp. 95-104
Analysis of behavior in the planarian model
Nicolas, C. L., Abramson, C. I., and Levin, M. (2008)
in R. B. Raffa & S. M. Rawls (Eds.), Planaria: A Model for Drug Action and Abuse, RG Landes Co.: Austin, pp. 83-94
What's Left in Asymmetry?
Aw, S., and Levin, M. (2008)
Developmental Dynamics, 237(12): 3453-3464
Planarians: a versatile and powerful model system for molecular studies of regeneration, adult stem cell regulation, aging, and behavior
Oviedo, N., Nicolas, C. L., Adams, D. S., and Levin, M. (2008)
Cold Spring Harbor Protocols, 3(10): pdb.em0101
Planarians: a versatile and powerful model system for molecular studies of regeneration, adult stem cell regulation, aging, and behavior
Oviedo, N., Nicolas, C. L., Adams, D. S., and Levin, M. (2008)
in Emerging Model Organisms: A Laboratory Manual, Volume 1, Cold Spring Harbor Press: Cold Spring Harbor NY, Chapter 8
Tail regeneration in Xenopus laevis as a model for understanding tissue repair
Tseng, A-S., and Levin, M. (2008)
Journal of Dental Research, 87(9): 806-816
2007
Apoptosis is required during early stages of tail regeneration in Xenopus laevis
Tseng, A-S., Adams, D. S., Qiu, D., Koustubhan, P., and Levin, M. (2007)
Developmental Biology, 301(1): 62-69
H+ Pump-dependent changes in membrane voltage are an early mechanism necessary and sufficient to induce Xenopus tail regeneration
Adams, D. S., Masi, A., and Levin, M. (2007)
Development, 134(7): 1323-1335 [cover]
smedxin-11 is a Planarian Stem Cell Gap Junction Gene Required for Regeneration and Homeostasis
Oviedo, N. J., and Levin, M. (2007)
Development, 134(17): 3121-3131
H,K-ATPase protein Localization and Kir4.1 function reveal concordance of three axes during early determination of left-right asymmetry
Aw, S., Adams, D. S., Qiu, D., and Levin, M. (2007)
Mechanisms of Development, 125(3-4): 353-372
Establishing and maintaining a Xenopus laevis colony for research laboratories
Koustubhan, P., Sorocco, D., and Levin, M. (2007)
in M. Conn (Ed.), Source Book of Models for Biomedical Research, Humana Press, pp. 139-160
Left-right patterning from the inside out: widespread evidence for intracellular control
Levin, M., and Palmer, R. (2007)
BioEssays, 29(3): 271-287
Gap junctional communication in morphogenesis
Levin, M. (2007)
Progress in Biophysics and Molecular Biology, 94(1-2): 186-206
Large-Scale Biophysics: Ion Flows and Regeneration
Levin, M. (2007)
Trends in Cell Biology, 17(6): 261-270 [cover]
What lies at the interface of regenerative medicine and developmental biology?
Ingber, D., and Levin, M. (2007)
Development, 134(14): 2541-2547
Gap junctions provide new links in Left-Right patterning
Oviedo, N., and Levin, M. (2007)
Cell, 129(4): 645-647
2006
Ion flow regulates left-right asymmetry in sea urchin development
Hibino, T., Ishii, Y., Levin, M., and Nishino, A. (2006)
Development Genes and Evolution, 216(5): 265-276
Evidence for the regulation of left-right asymmetry in Ciona intestinalis by ion flux
Shimeld, S. M., and Levin, M. (2006)
Developmental Dynamics, 235(6): 1543-1553
Early, H+-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates
Adams, D. S., Robinson, K. R., Fukumoto, T., Yuan, S., Albertson, R. C., Yelick, P., Kuo, L., McSweeney, M., and Levin, M. (2006)
Development, 133(9): 1657-1671
Automated Analysis of Behavior: A Computer-Controlled System for Drug Screening and the Investigation of Learning
Hicks, C., Sorocco, D., and Levin, M. (2006)
Journal of Neurobiology, 66(9): 977-990
Mathematical Model of Morphogen Electrophoresis through Gap Junctions
Esser, A. T., Smith, K. C., Weaver, J. C., and Levin, M. (2006)
Developmental Dynamics, 235(8): 2144-2159
Inverse Drug Screens: a rapid and inexpensive method for implicating molecular targets
Adams, D. S., and Levin, M. (2006)
Genesis, 44(11): 530-540
Strategies and techniques for investigation of biophysical signals in patterning
Adams, D., and Levin, M. (2006)
in M. Whitman and A. K. Sater (Eds.), Analysis of Growth Factor signaling in Embryos. Methods in Signal Transduction Series, CRC Press: Boca Raton FL, pp. 177-264
Of Minds and Embryos: Left-Right Asymmetry and the Serotonergic Controls of Pre-Neural Morphogenesis
Levin, M., Buznikov, G. A., and Lauder, J. M. (2006)
Developmental Neuroscience, 28(3): 171-185 [cover]
Is the Early Left-Right Axis like a Plant, a Kidney, or a Neuron? The Integration of Physiological Signals in Left-Right Asymmetry
Levin, M. (2006)
Birth Defects Research (Part C), 78(3): 191-223
2005
Asymmetric expression of Syndecan-2 in early chick embryogenesis
Fukumoto, T., and Levin, M. (2005)
Gene Expression Patterns, 5(4): 525-528
Serotonin signaling is a very early step in patterning of the left-right axis in chick and frog embryos
Fukumoto, T., Kema, I. P., and Levin, M. (2005)
Current Biology, 15(9): 794-803
Eye regeneration assay reveals an invariant functional left-right asymmetry in the early bilaterian, Dugesia japonica
Nogi, T., Yuan, Y. E., Sorocco, D., Perez-Tomas, R., and Levin, M. (2005)
Laterality, 10(3): 193-205
Localization and loss-of-function implicates ciliary proteins in early, cytoplasmic roles in left-right asymmetry
Qiu, D., Cheng, S. M., Wozniak, L., McSweeney, M., Perrone, E., and Levin, M. (2005)
Developmental Dynamics, 234(1): 176-189
Xenopus TRPN1 (NOMPC) localizes to microtubule-based cilia in epithelial cells, including inner-ear hair cells
Shin, J-B., Adams, D., Paukert, M., Siba, M., Sidi, S., Levin, M., Gillespie, P. G., and Grunder, S. (2005)
Proceedings of the National Academy of Sciences of the United States, 102(35): 12572-12577
BMP-3 is a novel inhibitor of both activin and BMP-4 signaling in Xenopus embryos
Gamer, L. W., Nove, J., Levin, M., and Rosen, V. (2005)
Developmental Biology, 285(1): 156-168
Characterization of innexin gene expression and functional roles of gap-junctional communication in planarian regeneration
Nogi, T., and Levin, M. (2005)
Developmental Biology, 287(2): 314-335
Serotonin transporter function is an early step in left-right patterning in chick and frog embryos
Fukumoto, T., Blakely, R., and Levin, M. (2005)
Developmental Neuroscience, 27(6): 349-363
Left-right asymmetry in embryonic development: a comprehensive review
Levin, M. (2005)
Mechanisms of Development, 122(1): 3-25 [cover]
2004
A novel immunohistochemical method for evaluation of antibody specificity and detection of labile targets in biological tissue
Levin, M. (2004)
Journal of Biophysical and Biochemical Methods, 58(1): 85-96
The embryonic origins of left-right asymmetry
Levin, M. (2004)
Critical Reviews in Oral Biology and Medicine, 15(4): 197-206
Early Patterning of the Left/Right Axis
Adams, D. S., and Levin, M. (2004)
in C. D. Stern (Ed.), Gastrulation: from cells to embryo, Cold Spring Harbor Laboratory Press: Long Island NY, pp. 403-417
2003
Fusicoccin signaling reveals 14-3-3 protein function as a novel step in left-right patterning during amphibian embryogenesis
Bunney, T. D., De Boer, A. H., and Levin, M. (2003)
Development, 130(20): 4847-4858
Bioelectromagnetics in morphogenesis
Levin, M. (2003)
Bioelectromagnetics, 24(5): 295-315
Motor protein control of ion flux is an early step in embryonic left-right asymmetry
Levin, M. (2003)
BioEssays, 25(10): 1002-1010
2002
Asymmetries in H+/K+-ATPase and cell membrane potentials comprise a very early step in left-right patterning
Levin, M., Thorlin, T., Robinson, K., Nogi, T., and Mercola, M. (2002)
Cell, 111(1): 77-89
Early embryonic expression of ion channels and pumps in chick and Xenopus development
Rutenberg, J., Cheng, S. M., and Levin, M. (2002)
Developmental Dynamics, 225(4): 469-484
Katp channel activity is required for hatching in Xenopus
Cheng, S. M., Chen, I., and Levin, M. (2002)
Developmental Dynamics, 225(4): 588-591
Isolation and community: A review of the role of gap-junctional communication in embryonic patterning
Levin, M. (2002)
Journal of Membrane Biology, 185(3): 177-192
2001
Left-Right asymmetry determination in vertebrates
Mercola, M., and Levin, M. (2001)
Annual Review of Cell and Developmental Biology, 17: 779-805
Asymmetry of Body and Brain: Embryological and Twin Studies
Levin, M. (2001)
in N. Smelser and P. Baltes (Eds.), International Encyclopedia of the Social and Behavioral Sciences, Elsevier: Oxford UK, pp. 853-859
2000
Expression of connexin 30 in Xenopus embryos and its involvement in hatching gland function
Levin, M., and Mercola, M. (2000)
Developmental Dynamics, 219(1): 96-101
1999
Matrix-based GA representations in a model of evolving animal communication
Levin, M. (1999)
in L. Chambers (Ed.), The Practical Handbook of Genetic Algorithms: Complex Coding Systems, Vol. 3, CRC Press: Boca Raton FL, Chapter 5, pp. 103-117
Twinning and embryonic left-right asymmetry
Levin, M. (1999)
Laterality, 4(3): 197-208
Cerberus regulates left-right asymmetry of the embryonic head and heart
Zhu, L., Marvin, M. J., Gardiner, A., Lassar, A. B., Mercola, M., Stern, C. D., and Levin, M. (1999)
Current Biology, 9(17): 931-938
Gap Junction-Mediated Transfer of Left-Right Patterning Signals in the Early Chick Blastoderm is Upstream of Shh Asymmetry in the Node
Levin, M., and Mercola, M. (1999)
Development, 126(21): 4703-4714
Left-right asymmetry in animal embryogenesis
Levin, M. (1999)
in G. Palyi, C. Zucchi, and L. Caglioti (Eds.), Advances in Biochirality, Elsevier Science Ltd: Oxford UK, Chapter 12, pp. 137-152
Endogenous electromagnetic fields and radiations in regeneration, development, and neoplasm
Levin, M. (1999)
Proceedings of the First World Congress on the Effects of Electricity and Magnetism in the Natural World, Madeira, Portugal
1998
The roles of activin and follistatin signaling in chick gastrulation
Levin, M. (1998)
International Journal of Developmental Biology, 42(4): 553-559
Gap junctions are involved in the early generation of left right asymmetry
Levin, M., and Mercola, M. (1998)
Developmental Biology, 203(1): 90-105
Evolutionary conservation of mechanisms upstream of asymmetric nodal expression: Reconciling chick and Xenopus
Levin, M., and Mercola, M. (1998)
Developmental Genetics, 23(3): 185-193
Left-Right asymmetry and the chick embryo
Levin, M. (1998)
Seminars in Cell & Developmental Biology, 9(1): 67-76
The compulsion of chirality: toward an understanding of left-right asymmetry
Levin, M., and Mercola, M. (1998)
Genes & Development, 12(6): 763-769
1997
Applied DC magnetic fields cause alterations in the time of cell divisions and developmental abnormalities in early sea urchin embryos
Levin, M., and Ernst, S. G. (1997)
Bioelectromagnetics, 18(3): 255-263
Left/Right Patterning Signals and the Independent Regulation of Different Aspects of Situs in the Chick Embryo
Levin, M., Pagan, S., Roberts, D. J., Cooke, J., Kuehn, M. R., and Tabin, C. J. (1997)
Developmental Biology, 189(1): 57-67
Two molecular models of initial left-right asymmetry generation
Levin, M., and Nascone, N. (1997)
Medical Hypotheses, 49(5): 429-435
Left-right asymmetry in vertebrate embryogenesis
Levin, M. (1997)
BioEssays, 19(4): 287-296 [cover]
1996
Laterality defects in conjoined twins
Levin, M., Roberts, D. J., Holmes, L. B., and Tabin, C. (1996)
Nature, 384(6607): 321
1995
Applied AC and DC Magnetic Fields Cause Alterations in the Mitotic Cycle of Early Sea Urchin Embryos
Levin, M., and Ernst, S. G. (1995)
Bioelectromagnetics, 16(4): 231-240
A molecular pathway determining left-right asymmetry in chick embryogenesis
Levin, M., Johnson, R. L., Stern, C. D., Kuehn, M., and Tabin, C. (1995)
Cell, 82(5): 803-814 [cover]
Use of Genetic Algorithms to Solve Biomedical Problems
Levin, M. (1995)
M.D. Computing, 12(3): 193-198
The evolution of understanding: A genetic algorithm model of the evolution of animal communication
Levin, M. (1995)
BioSystems, 36(3): 167-178
Locating putative protein signal sequences
Levin, M. (1995)
in L. Chambers (Ed.), The Practical Handbook of Genetic Algorithms: New Frontiers, Vol. 2, CRC Press: Boca Raton FL, Chapter 2, pp. 53-66
1994
A Julia set model of field-directed morphogenesis: developmental biology and artificial life
Levin, M. (1994)
Computer Applications in the Biosciences, 10(2): 85-103
Discontinuous and alternate q-system fractals
Levin, M. (1994)
Computers and Graphics, 18(6): 873-884
1993
Current and potential applications of bioelectromagnetics in medicine
Levin, M. (1993)
Subtle Energies and Energetic Medicine Journal, 4(1): 77-87
Conferences, Abstracts, and Poster Sessions
SBMLtoODEjax: Efficient Simulation and Optimization of Biological Network Models in JAX
Etcheverry, M., Levin, M., Moulin-Frier, C., and Oudeyer, P.-Y. (2023)
NeurIPS 2023 AI for Science Workshop, New Orleans, LA
Brief multi-drug treatment via a wearable silk-hydrogel bioreactor induces long-term limb re-patterning and regeneration in adult Xenopus Laevis
Murugan, N., Vigran, H., Miller, K., Pham, Q., Golding, A., Kane, A., Kaplan, D., and Levin, M. (2021)
The FASEB Journal, 35(S1), doi:10.1096/fasebj.2021.35.s1.03874
Xenopticon: Microfluidic platform for time-resolved analysis of Xenopus embryo development
Novak, R., Choe, Y., Dinis, A., Ingram, M., Keshari, V., Nestor, B. A., Super, M., Levin, M., and Ingber, D. E. (2020)
Proceedings of 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2017), 1639-1640
Transmembrane voltage gradient in GlyR-expressing niche cells controls behavior of neural crest derivatives in vivo
Blackiston, D., Adams, D., Lemire, J., and Levin, M. (2010)
Developmental Biology, 344(1): 526
Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration
Oviedo, N. J., Morokuma, J., Walentek, P., Kema, I. P., Gu, M. B., Ahn, J. M., Hwang, J. S., Gojobori, T., Levin, M. (2010)
Developmental Biology, 344(1): 522
NaV-mediated sodium transport is required for vertebrate appendage regeneration
Tseng, A. S., Beane, W. S., Lemire, J. M., Masi, A., and Levin, M. (2010)
Developmental Biology, 344(1): 519
H,K-ATPase-mediated ion transport regulates anterior patterning in regenerating planaria
Beane W. S., Morokuma J., and Levin, M. (2010)
Developmental Biology, 344(1): 522
The Par6 complex is required for both early and late orientation of the left-right axis in Xenopus
Vandenberg, L., and Levin, M. (2010)
Developmental Biology, 344(1): 426-427
H,K-ATPase-mediated ion transport regulates anterior patterning in regenerating planaria
Beane W. S., Oviedo N.J., Adams D. S., and Levin, M. (2009)
Mechanisms of Development, 126 (Sup. 1): S294-S295
Role of KvLQT-1/minK K+ channel in early embryonic patterning
Morokuma, J., and Levin, M. (2006)
Developmental Biology, 295(1): 451
A leftward fluid flow precedes nodal induction in Xenopus
Blum, M., Schweickert, A., Beyer, T., Weber, T., Andre, P., Fischer, A., Viebahn, C., and Levin, M. (2006)
Developmental Biology, 295(1): 443
Xenopus tadpole tail regeneration requires the activity of the proton pump V- ATPase, and proton pumping is sufficient to partially rescue the loss of function phenotype
Adams, D. S., Masi, A., and Levin, M. (2006)
Developmental Biology, 295(1): 355-356
Bioelectrical controls of morphogenesis
Levin, M., Adams, D. S., Aw, S., Morokuma, J., and Oviedo, N. J. (2006)
Developmental Biology, 295(1): 331-332
The Role of KATP Channels in Development of Left-Right Asymmetry in Xenopus
Chen, I., and Levin, M. (2004)
Journal of Dental Research, 83: A1340
Electrical Controls of Regeneration in Planaria
Nogi, T. and Levin, M. (2003)
Developmental Biology, 259: 586
Electric Embryos: Endogenous Ion Fluxes and Voltage Gradients in Left—Right Asymmetry
Levin, M. (2003)
Developmental Biology, 259: 482
Elements of Left—Right Patterning: Gap Junctions, pH, and Membrane Voltage
Adams, D., and Levin, M. (2003)
Developmental Biology, 259: 482-483
Serotonin Is a Novel Very Early Signaling Mechanism in Left—Right Asymmetry
Fukumoto, T., and Levin, M. (2003)
Developmental Biology, 259: 490
Gap junction-mediated transfer of left-right patterning signals
Levin, M., and Mercola, M. (1999)
Molecular Biology of the Cell, 39: 1
From left-right asymmetric gene expression to its morphological manifestations
Pagan, S. M., Levin, M., and Tabin, C. (1997)
Journal of Morphology, 232(3): 306
DC and AC magnetic field effects on early sea-urchin development
Levin, M., Gonzalez, J. L., and Ernst, S. G. (1991)
Biological Bulletin, 181: 511