Planaria

Cellular Competency during Development Alters Evolutionary Dynamics in an Artificial Embryogeny Model
Shreesha, L., and Levin, M. (2023)
Entropy, 25(1): 131

Transplantation of fragments from different planaria: a bioelectrical model for head regeneration
Cervera, J., Manzanares, J. A., Levin, M., and Mafe, S. (2023)
Journal of Theoretical Biology, 558: 111356

A Computational Approach to Explaining Bioelectrically-induced Persistent, Stochastic Changes of Axial Polarity in Planarian Regeneration
Grodstein, J., and Levin, M. (2022)
Bioelectricity, 4(1): 18-30

Nervous System and Tissue Polarity Dynamically Adapt to New Morphologies in Planaria
Bischof, J., Day, M., Miller, K., LaPalme, J., and Levin, M. (2020)
Developmental Biology, 467(1-2): 51-65

Regulation of axial and head patterning during planarian regeneration by a commensal bacterium
Williams, K., Bischof, J., Lee, F., Miller, K., LaPalme, J., Wolfe, B., and Levin, M. (2020)
Mechanisms of Development, 163: 103614

Does regeneration recapitulate phylogeny?
Fields, C., and Levin, M. (2020)
Communicative & Integrative Biology, 13(1): 27-38

Bioelectrical model of head-tail patterning based on cell ion channels and intercellular gap junctions
Cervera, J., Meseguer, S., Levin, M., and Mafe, S. (2020)
Bioelectrochemistry, 132: 107410

Regenerative Adaptation to Electrochemical Perturbation in Planaria: A Molecular Analysis of Physiological Plasticity
Emmons-Bell, M., Durant, F., Tung, A., Pietak, A., Miller, K., Kane, A., Martyniuk, C. J., Davidian, D., Morokuma, J., and Levin, M. (2019)
iScience, 22: 147-165

Live Imaging of Intracellular pH in Planarians Using the Ratiometric Fluorescent Dye SNARF-5F-AM
Beane, W. S., Adams, D. S., Morokuma, J., and Levin, M. (2019)
Biology Methods and Protocols, 4(1): bpz005

Neural control of body-plan axis in regenerating planaria
Pietak, A., Bischof, J., LaPalme, J., Morokuma, J., and Levin, M. (2019)
PLOS Computational Biology, 15(4): e1006904

Effects of ivermectin exposure on regeneration of D. dorotocephala planaria: exploiting human-approved ion channel drugs as morphoceuticals
Ferenc, N. N., and Levin, M. (2019)
Macromolecular Bioscience, 19(3): 1800237

Planarian Regeneration as a Model of Anatomical Homeostasis: Recent Progress in Biophysical and Computational Approaches
Levin, M., Pietak, A., and Bischof, J. (2019)
Seminars in Cell and Developmental Biology, 87: 125-144

The role of early bioelectric signals in the regeneration of planarian anterior/posterior polarity
Durant, F., Bischof, J., Fields, C., Morokuma, J., LaPalme, J., Hoi, A., and Levin, M. (2019)
Biophysical Journal, 116(5): 948-961

The bacterial metabolite indole inhibits regeneration of the planarian flatwork Dugesia japonica
Lee, F. J., Williams, K. B., Levin, M., and Wolfe, B. E. (2018)
iScience, 10: 135-148

Modeling Cell Migration in a Simulated Bioelectrical Signaling Network for Anatomical Regeneration
Ferreira, G. B. S., Scheutz, M., and Levin, M. (2018)
in T. Ikegami, N. Virgo, O. Witkowski, M. Oka, R. Suzuki, and H. Iizuka (Eds.), ALIFE 2018: The 2018 Conference on Artificial Life. MIT Press: Tokyo, p. 194-201

Bioelectrical control of positional information in development and regeneration: a review of conceptual and computational advances
Pietak, A., and Levin, M. (2018)
Progress in Biophysics and Molecular Biology, 137: 52-68

Are planaria individuals? What regenerative biology is telling us about the nature of multicellularity
Fields, C., and Levin, M. (2018)
Evolutionary Biology, 45(3): 237-247

Long-Term, Stochastic Editing of Regenerative Anatomy via Targeting Endogenous Bioelectric Gradients
Durant, F., Morokuma, J., Fields, C., Williams, K., Adams, D. S., and Levin, M. (2017)
Biophysical Journal, 112(10): 2231-2243

Space travel has effects on planarian regeneration that cannot be explained by a null hypothesis
Levin, M., Morokuma, J., and Finkelstein, J. (2017)
Regeneration, 4(4): 156-158

Planarian regeneration in space: persistent anatomical, behavioral, and bacteriological changes induced by space travel
Morokuma, J., Durant, F. R., Williams, K. B., Finkelstein, J. M., Blackiston, D. J., Clements, T., Reed, D. W., Roberts, M., Jain, M., Kimel, K., Trayger, S. A., Wolfe, B. E., and Levin, M. (2017)
Regeneration, 4(2): 85-102

Computing a worm: reverse-engineering planarian regeneration
Lobo, D., and Levin, M. (2017)
in Adamatzky, A. (Ed), Advances in Unconventional Computing. Emergence, Complexity and Computation, vol 23, Springer: Cham, pp. 637-654

Vertically and horizontally-transmitted memories – the fading boundaries between regeneration and inheritance in planaria
Neuhof, M., Levin, M., and Rechavi, O. (2016)
Biology Open, 5(9): 1177-1188

Physiological Inputs Regulate Species-Specific Anatomy During Embryogenesis and Regeneration
Sullivan, K. G., Emmons-Bell, M., and Levin, M. (2016)
Communicative & Integrative Biology, 9(4): e1192733

Computational discovery and in vivo validation of hnf4 as a regulatory gene in planarian re-generation
Lobo, D., Morokuma, J., and Levin, M. (2016)
Bioinformatics, 32(17): 2681-2685

Physiological controls of large-scale patterning in planarian regeneration: a molecular and computational perspective on growth and form
Durant, F., Lobo, D., Hammelman, J., and Levin, M. (2016)
Regeneration, 3(2): 78-102

Gap junctional blockade stochastically induces different species-specific head anatomies in genetically wild-type Girardia dorotocephala flatworms
Emmons-Bell, M., Durant, F., Hammelman, J., Bessonov, N., Volpert, V., Morokuma, J., Pinet, K., Adams, D. S., Pietak, A., Lobo, D., and Levin, M. (2015)
International Journal of Molecular Sciences, 16(11): 27865-27896

Inferring regulatory networks from experimental morphological phenotypes: a computational method reverse-engineers planarian regeneration
Lobo, D., and Levin, M. (2015)
PLoS Computational Biology, 11(6): e1004295

An automated training paradigm reveals long-term memory in planaria and its persistence through head regeneration
Shomrat, T., and Levin, M. (2013)
Journal of Experimental Biology, 216(20): 3799-3810
Overview

Towards a bioinformatics of patterning: a computational approach to understanding regulative morphogenesis
Lobo, D., Malone, T. J., and Levin, M. (2013)
Biology Open, 2(2): 156-169

Bioelectric signaling regulates head and organ size during planarian regeneration
Beane, W. S., Morokuma, J., Lemire, J. M., and Levin, M. (2013)
Development, 140(2): 313-322

Inhibition of planar cell polarity extends neural growth during regeneration, homeostasis, and development
Beane, W. S., Tseng, A.-S., Morokuma, J. M., Lemire, J. M., and Levin, M. (2012)
Stem Cells and Development, 21(12): 2085-2094

Modeling planarian regeneration: a primer for reverse-engineering the worm
Lobo, D., Beane, W., and Levin, M. (2012)
PLoS Computational Biology, 8(4): e1002481

A chemical genetics approach reveals H,K-ATPase-mediated membrane voltage is required for planarian head regeneration
Beane, W. S., Morokuma, J., Adams, D. S., and Levin, M. (2011)
Chemistry & Biology, 18(1): 77-89

A second-generation device for automated training and quantitative behavior analyses of molecularly tractable model organisms
Blackiston, D., Shomrat, T., Nicolas, C. L., Granata, C., and Levin, M. (2010)
PLoS One, 5(12): e14370

Long-range Neural and Gap Junction Protein-mediated Cues Control Polarity During Planarian Regeneration
Oviedo, N. J., Morokuma, J., Walentek, P., Kema, I. P., Gu, M. B., Ahn, J. M., Hwang, J. S., Gojobori, T., and Levin, M. (2010)
Developmental Biology, 339(1): 188-199

Planarian PTEN homologs regulate stem cells and regeneration through TOR signaling
Oviedo, N. J., Pearson, B. J., Levin, M., and Alvarado, A. S. (2008)
Disease Models and Mechanisms, 1(2-3): 131-143

Live imaging of planarian membrane potential using DiBAC4(3)
Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M. (2008)
Cold Spring Harbor Protocols, 3(10): pdb.prot5055

Gene knockdown in planarians using RNA interference
Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M. (2008)
Cold Spring Harbor Protocols, 3(10): pdb.prot5054

Establishing and maintaining a colony of planarians
Oviedo, N. J., Nicolas, C. L., Adams, D. S., and Levin, M. (2008)
Cold Spring Harbor Protocols, 3(10): pdb.prot5053

The planarian regeneration model as a context for the study of drug effects and mechanisms
Oviedo, N., and Levin, M. (2008)
in R. B. Raffa & S. M. Rawls (Eds.), Planaria: A Model for Drug Action and Abuse, RG Landes Co.: Austin, pp. 95-104

Analysis of behavior in the planarian model
Nicolas, C. L., Abramson, C. I., and Levin, M. (2008)
in R. B. Raffa & S. M. Rawls (Eds.), Planaria: A Model for Drug Action and Abuse, RG Landes Co.: Austin, pp. 83-94

Planarians: a versatile and powerful model system for molecular studies of regeneration, adult stem cell regulation, aging, and behavior
Oviedo, N., Nicolas, C. L., Adams, D. S., and Levin, M. (2008)
Cold Spring Harbor Protocols, 3(10): pdb.em0101

Automated Analysis of Behavior: A Computer-Controlled System for Drug Screening and the Investigation of Learning
Hicks, C., Sorocco, D., and Levin, M. (2006)
Journal of Neurobiology, 66(9): 977-990

Eye regeneration assay reveals an invariant functional left-right asymmetry in the early bilaterian, Dugesia japonica
Nogi, T., Yuan, Y. E., Sorocco, D., Perez-Tomas, R., and Levin, M. (2005)
Laterality, 10(3): 193-205

Characterization of innexin gene expression and functional roles of gap-junctional communication in planarian regeneration
Nogi, T., and Levin, M. (2005)
Developmental Biology, 287(2): 314-335