Preprints

Bioelectric Pharmacology of Cancer: A Meta-Analysis of Ion Channel Drugs Affecting the Cancer Phenotype
Kofman, K., and Levin, M. (2024)
OSF Preprints, doi:10.31219/osf.io/qkuvf

Classical Sorting Algorithms as a Model of Morphogenesis: self-sorting arrays reveal unexpected competencies in a minimal model of basal intelligence
Zhang, T., Goldstein, A., and Levin, M. (2023)
OSF Preprints, doi:10.31219/osf.io/e5d4u

AI-driven Automated Discovery Tools Reveal Diverse Behavioral Competencies of Biological Networks
Etcheverry, M., Moulin-Frier, C., Oudeyer, P.-Y., and Levin, M. (2023)
OSF Preprints, doi:10.31219/osf.io/s6thq

Programmable delivery of fluoxetine via wearable bioelectronics for wound healing in vivo
Li, H., Yang, H.-Y., Asefifeyzabadi, N., Baniya, P., Medina Lopez, A., Gallegos, A., Zhu, K., Hsieh, H.-C., Nguyen, T., Hernandez, C., Zlobina, K., Recendez, C., Tebyani, M., Carrión, H., Selberg, J., Luo, L., Alhamo, M. A., Soulika, A. M., Levin, M., Norouzi, N., Gomez, M., Zhao, M., Teodorescu, M., Isseroff, R. R., and Rolandi, M. (2023)
bioRxiv, doi:10.1101/2023.10.10.561754

Requirements for self organization: What do you need to have a structure emerge spontaneously?
Sacco, F., Sakthivadivel, D., and Levin, M. (2023)
Github, doi:10.5281/zenodo.8416764

Machine Learning for Hypothesis Generation in Biology and Medicine: Exploring the latent space of neuroscience and developmental bioelectricity
O’Brien, T., Stremmel, J., Pio-Lopez, L., McMillen, P., Rasmussen-Ivey, C., and Levin, M. (2023)
OSF Preprints, doi:10.31219/osf.io/269e5

SBMLtoODEjax: efficient simulation and optimization of ODE SBML models in JAX
Etcheverry, M., Levin, M., Moulin-Frier, C., and Oudeyer, P.-Y. (2023)
arXiv, doi:10.48550/arXiv.2307.08452

Embryos Assist Each Other’s Morphogenesis: calcium and ATP signaling mechanisms in collective resistance to teratogens
Tung, A., Sperry, M., Clawson, W., Pavuluri, A., Bulatao, S., Yue, M., Flores, R. M., Pai, V. McMillen, P., Kuchling, F., and Levin, M. (2023)
OSF Preprints, doi:10.31219/osf.io/ps987

Aging as a morphostasis defect: a developmental bioelectricity perspective
Pio-Lopez, L., and Levin, M. (2023)
OSF Preprints, doi:10.31219/osf.io/wkhx4

Nested Selves: Self-Organisation and Shared Markov Blankets in Prenatal Development in Humans
Ciaunica, A., Levin, M., Rosas, F., and Friston, K. (2023)
PsyArXiv, doi:10.31234/osf.io/g8q5d

The Yin and Yang of Breast Cancer: Ion Channels as Determinants of Left-Right Functional Differences
Masuelli, S., Real, S., McMillen, P., Oudin, M., Levin, M., Roqué, M. (2023)
Preprints.org, 2023051160, doi:10.20944/preprints202305.1160.v1

Control flow in active inference systems
Fields, C., Fabrocini, F., Friston, K., Glazebrook, J. F., Hazan, H., Levin, M. and Marcianò, A. (2023)
arXiv, doi:10.48550/arXiv.2303.01514

Darwin’s Agential Materials: evolutionary implications of multi-scale competency in developmental biology
Levin, M. (2023)
OSF Preprints, doi:10.31219/osf.io/p23se

Towards an Ethics of Autopoietic Technology: Stress, Care, and Intelligence
Witkowski, O., Doctor, T., Solomonova, E., Duane, B., and Levin, M. (2023)
PsyArXiv, doi:10.31234/osf.io/pjrd2

Identification of a pharmaceutical biostasis inducer that slows metabolism in multiple vertebrates that do not hibernate
Sperry, M. M., Charrez, B., Fotowat, H., Gardner, E., Pilobello, K., Izadifar, Z., Lin, T., Kuelker, A., Kaki, S., Lewandowski, M., Lightbown, S., Martinez, R., Marquez, S., Sesay, A., Shcherbina, K., Takeda, T., Andrijauskaite, K., Cisneros, E., Lopez, R., Cano, I., Maxwell, Z., Veraza, R., Bunegin, L., Percival, T. J., Yracheta, J., Pena, J. J., Wood, D. M., Homas, Z. T., Hinshaw, C. J., Cox-Hinshaw, J., Parry, O. G., Sleeter, J. J., Weitzel, E., Levin, M., Super, M., Novak, R., and Ingber, D. E. (2023)
bioRxiv, doi:10.1101/2023.02.27.530270

Information integration during bioelectric regulation of morphogenesis in the embryonic frog brain
Manicka, S., Pai, V. P, and Levin, M. (2023)
bioRxiv, doi:10.1101/2023.01.08.523164

Morphoceuticals: perspectives for discovery of drugs targeting anatomical control mechanisms in regenerative medicine, cancer, and aging
Pio-Lopez, L., and Levin, M. (2022)
OSF Preprints, doi:10.31219/osf.io/7hxnp

There’s Plenty of Room Right Here: Biological Systems as Evolved, Overloaded, Multi-scale Machines
Bongard, J., and Levin, M. (2022)
arXiv, doi:10.48550/arXiv.2212.10675

The scaling of goals via homeostasis: an evolutionary simulation, experiment and analysis
Pio-Lopez, L., Bischof, J., LaPalme, J. V., and Levin, M. (2022)
arXiv, doi:10.48550/arXiv.2211.08522

Cellular Signaling Pathways as Plastic, Proto-cognitive Systems: Implications for Biomedicine
Mathews, J., Chang, J., Devlin, L., and Levin, M. (2022)
OSF Preprints, doi:10.31219/osf.io/c6n9r

Closing the Loop on Morphogenesis: A Mathematical Model of Morphogenesis by Closed-Loop Reaction-Diffusion
Grodstein, J., and Levin, M. (2022)
arXiv, doi:10.48550/arXiv.2211.01313

Exploring The Behavior of Bioelectric Circuits using Evolution Heuristic Search
Hazan, H., and Levin, M. (2022)
bioRxiv, doi:10.1101/2022.10.23.513361

Regulative development as a model for origin of life and artificial life studies
Fields, C., and Levin, M. (2022)
PsyArXiv, doi:10.31234/osf.io/rdt7f

The Brain is not Mental! Coupling Neuronal and Immune Cellular Processing in Human Organisms
Ciaunica, A., and Levin, M. (2022)
PsyArXiv, doi:10.31234/osf.io/fgcy5

Motile Living Biobots Self-Construct from Adult Human Somatic Progenitor Seed Cells
Gumuskaya, G., Srivastava, P., Cooper, B. G., Lesser, H., Semegran, B., Garnier, S., and Levin, M. (2022)
bioRxiv, doi:10.1101/2022.08.04.502707

Competency of the Developmental Layer Alters Evolutionary Dynamics in an Artificial Embryogeny Model of Morphogenesis
Shreesha, L., and Levin, M. (2022)
arXiv, doi:10.48550/arXiv.2207.14729

The nonlinearity of regulation in biological networks
Manicka, S., Johnson, K., Levin, M., and Murrugarra, D. (2022)
bioRxiv, doi:10.1101/2021.12.22.473903

Information Theory as an experimental tool for integrating disparate biophysical signaling modules
McMillen, P., and Levin, M. (2022)
Preprints.org, doi:10.20944/preprints202207.0376.v1

Active Inference, Morphogenesis, and Computational Psychiatry
Pio-Lopez, L., Kuchling, F., Tung, A., Pezzulo, G., and Levin, M. (2022)
PsyArXiv, doi:10.31234/osf.io/4gp6c

Screening biophysical sensors and actuators that influence wound healing in human induced pluripotent stem cell-derived neurons
Pai, V. P., Cooper, B., and Levin, M. (2022)
Preprints.org, 2022070083, doi:10.20944/preprints202207.0083.v1

Biological Robots: Perspectives on an Emerging Interdisciplinary Field
Blackiston, D., Kriegman, S., Bongard, J., and Levin, M. (2022)
arXiv, doi:10.48550/arXiv.2207.00880

Synthetic Morphology via Active and Agential Matter
Davies, J., and Levin, M. (2022)
OSF Preprints, doi:10.31219/osf.io/xrv8h

Collective Intelligence of Morphogenesis as a Teleonomic Process
Levin, M. (2022)
PsyArXiv, doi:10.31234/osf.io/hqc9b

Competency in Navigating Arbitrary Spaces: Intelligence as an Invariant for Analyzing Cognition in Diverse Embodiments
Fields, C., and Levin, M. (2022)
PsyArxiv, doi:10.31234/osf.io/87nzu

Target-agnostic discovery of Rett Syndrome therapeutics by coupling computational network analysis and CRISPR-enabled in vivo disease modeling
Novak, R., Lin, T., Kaushal, S., Sperry, M., Vigneault, F., Gardner, E., Loomba, S., Shcherbina, K., Keshari, V. , Dinis, A., Vasan, A., Chandrasekhar, V., Takeda, T., Turner, J. R., Levin, M., and Ingber, D. E. (2022)
bioRxiv, doi:10.1101/2022.03.20.485056doi

Memory via Temporal Delays in weightless Spiking Neural Network
Hazan, H., Caby, S., Earl, C., Siegelmann, H., and Levin, M. (2022)
arXiv, doi:10.48550/arXiv.2202.07132

Neurons as hierarchies of quantum reference frames
Fields, C., Glazebrook, J. F., and Levin, M. (2022)
arXiv, doi:10.48550/arXiv.2201.00921

Biology, Buddhism, and AI: Care as the Driver of Intelligence
Doctor, T., Witkowski, O., Solomonova, E., Duane, B., and Levin, M. (2022)
MindRxiv, 10 Mar. 2022

Technological Approach to Mind Everywhere (TAME): an experimentally-grounded framework for understanding diverse bodies and minds
Levin, M. (2021)
PsyArXiv, doi:10.31234/osf.io/t6e8p

Enhancers of host immune tolerance to bacterial infection discovered using linked computational and experimental approaches
Sperry, M., Novak, R., Keshari, V., Dinis, A. L. M., Cartwright, M. J., Camacho, D. M., Pare, J-F, Super, M., Levin, M., and Ingber, D. E. (2021)
bioRxiv, doi:10.1101/2021.09.30.462576

Physarum polycephalum: Establishing an Assay for Testing Decision-making Under Shifting Somatic Boundaries
Levin, S. P., and Levin, M. (2021)
bioRxiv, doi:10.1101/2021.10.17.464734

Potassium channel-driven bioelectric signaling regulates metastasis in triple-negative breast cancer
Payne, S. K., Ram, P., Srinivasan, D. H., Le, T. T., Levin, M., and Oudin, M. J. (2021)
bioRxiv, doi:10.1101/2021.04.06.438714

Metabolic limits on classical information processing by biological cells
Fields, C., and Levin, M. (2021)
arXiv, doi:10.48550/arXiv.2103.17061

Scale invariant robot behavior with fractals
Kriegman, S., Nasab, A. M., Blackiston, D., Steele, H., Levin, M., Kramer-Bottiglio, R., and Bongard, R. (2021)
arXiv, doi:10.48550/arXiv.2103.04876

Formation and Spontaneous Long-Term Repatterning of Headless Planarian Flatworms
Bischof, J., LaPalme, J., Miller, K., Morokuma, J., Williams, K., Fields, C., and Levin, M. (2021)
bioRxiv, doi:10.1101/2021.01.15.426822

Epigenetic immune-modulation by Histone Deacetylase Activity (HDAC) of tissue and organ regeneration in Xenopus laevis
Pentagna, N., Soares dos Santos, F., Martins de Almeida, F., Abreu, J. G., Levin, M., and Carneiro, K. (2020)
bioRxiv, doi:10.1101/2020.02.05.936294

BindsNET – A Framework for Spiking Neuronal Simulation
Hazan, H., Levin, M. (2020)
Medium

Evolution leads to emergence: An analysis of protein interactomes across the tree of life
Hoel, E., Klein, B., Swain, A., Grebenow, R., Levin, M. (2020)
bioRxiv, doi:10.1101/2020.05.03.074419

Mechanosensation Mediates Long-Range Spatial Decision-Making in an Aneural Organism
Murugan, N., Kaltman, D., Jin, H., Chien, M., Flores, R., Nguyen, C., Tuzoff, D., Minabutdinov, A., Kane, A., Novak, R., and Ingber, D. (2020)
bioRxiv, doi:10.1101/2020.03.20.985523

Scalable sim-to-real transfer of soft robot designs
Kriegman, S., Nasab, A. M., Shah, D., Steele, H., Branin, G., Levin, M., Bongard, J., and Kramer-Bottiglio, R. (2020)
arXiv, doi:10.48550/arXiv.1911.10290

S-adenosylhomocysteine hydrolase regulates anterior patterning in Dugesia japonica
Reinmets, K., Bischof, J., Taketa, E., Levin, M., and Fuchs, S. M. (2020)
bioRxiv, doi:10.1101/2020.01.22.916072

Automated shapeshifting for function recovery in damaged robots
Kriegman, S., Walker, S., Shah, D., Levin, M., Kramer-Bottiglio, R., and Bongard, J. (2019)
arXiv, doi: 10.15607/RSS.2019.XV.028

Modeling somatic computation with non-neural bioelectric networks
Manicka, S., and Levin., M. (2019)
arXiv, doi: 10.1038/s41598-019-54859-8

Bistability of Somatic Pattern Memories: Stochastic Outcomes in Bioelectric Circuits Underlying Regeneration
Pezzulo, G., LaPalme, J., Durant, F., and Levin, M. (2019)
Preprints.org, 2019110348

von Willebrand Factor D and EGF Domains is an evolutionarily conserved and required feature of blastemas capable of multi-tissue appendage regeneration
Leigh, N. D., Sessa, S., Dragalzew, A. C., Payzin-Dogru, D., Sousa, J. F., Aggouras, A., Johnson, K., Dunlap, G. S., Haas, B. J., Levin, M., Schneider, I., and Whited, J. L. (2019)
bioRxiv, doi: 10.1101/842948

A comprehensive conceptual and computational dynamics framework for Autonomous Regeneration Systems
Minh-Thai, T.N., Samarasinghe, S., and Levin, M. (2019)
bioRxiv, doi: 10.1101/820613

Nervous System and Tissue Polarity Dynamically Adapt to New Morphologies in Planaria
Bischof, J., Day, M.E., Miller, K.A., LaPalme, J., and Levin, M. (2019)
bioRxiv, doi: 10.1101/815688

Defined extracellular ionic solutions to study and manipulate the cellular resting membrane potential
Bonzanni, M., Payne, S. L., Adelfio, M., Kaplan, D. L., Levin, M., and Oudin, M.J. (2019)
bioRxiv, doi: 10.1101/785444

Cellular Migration May Exhibit Intrinsic Left-Right Asymmetries: A meta-analysis
Sullivan, K. G., Vandenberg, L. N., and Levin, M. (2018)
bioRxiv, doi: 10.1101/052191

Effects of Ivermectin exposure on regeneration of D. dorotocephala planaria
Ferenc, N. N., and Levin, M. (2017)
bioRxiv, doi: 10.1101/186650

From cytoskeletal dynamics to organ asymmetry: a non-linear, regulative pathway underlies left-right patterning
McDowell, G. S., Rajadurai, S., and Levin, M. (2016)
bioRxiv, doi: 10.1101/052191