
Research/Areas of Interest
Epigenetics, Aging, Cellular senescence, and Protein Regulation
The Tran lab focuses on epigenetic regulation during cellular senescence and aging. To better understand epigenetics, imagine your DNA as a letters and epigenetics as punctuation in a sentence. As an example, we can use the following sentence:
"I'm very hungry. Let's eat, grandma."
Without changing any letters in the sentence (DNA) but the punctuation (epigenetics), we can dramatically change the interpretation of the sentence.
"I'm very hungry! Let's eat grandma!"
My overall research focuses on understanding how these punctuation changes, what mediates these changes, and how they contribute to aging and age-related disorders.
Current research projects:
• Elucidate the intersection between metabolism and epigenetics in cellular senescence and aging.
• Understand how transcriptional regulators are spatially dysregulated during aging
• Characterize the epigenetic changes during aging and age-related disorders.
Please see my lab website for more information on research projects.
Biography
Outside of labs, you can find Dr. Tran running, reading comics or fantasy novels, and playing video games.